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Animal modeling in drug discovery and development - Essay Example

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According to Hughes, Rees, Kalindjian, and Philpott (2011), the process of developing a drug from a novel idea is an intricate and costly one that takes a period of around 15 years more than one US billion dollars. The main aim during the drug production process is the…
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Animal modeling in drug discovery and development
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Download file to see previous pages The target is described as the molecule or certain biological entities upon which the drug shall act and produce biological reactions that can be measured either in vivo or in vitro.
It is after the identification of the target that the it has to be validated. It is in the authentication that animal models, described as in vitro tools are integrated into the drug discovery and development process (Hughes, et al., 2011). The animal models are used to check for the efficacy of the identified molecule in the target. Most importantly, Mei and Czarnik (2002) indicate that the whole animal model data has to be obtained in order to ascertain the biological linkage of the target to a disease along with how the target can be utilised in the drug discovery and development process. The activity observed in the animal models does not imply decisiveness for the same in human beings, nevertheless, if there lacks any activity, then reconsideration has to be undertaken on the efficacy of the target (Mei & Czarnik, 2002).
The validity of the animal model data is vital in predicting the result for a particular drug during basic research (Denayer, Stohr, & Van Roy, 2014). Furthermore, the validity of the animal model permits for the evaluation of the functional outcomes. It has be recalled that this is in the preclinical trial of the research.
The validity of the animal model data is essential for availing vital information regarding the selectivity and potency of the drug for the human target. The two are vital components in determining if the drug works beyond the preclinical stage of the research. It is so for the in vitro data obtained from the animal models used. At the same time, the in vivo data avails a pharmacodynamics and a pharmacokinetic profile of the drug to be. The pharmacokinetic and the pharmacodynamics of the novel drug under research determines the drug affinity to the identified target and the how well it is distributed to the target. The ...Download file to see next pagesRead More
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