Nobody downloaded yet

Ppaer with draft - Research Paper Example

Comments (0) Cite this document
(Chamberlain, 2002) The primary cause of muscular dystrophy is the mutation of several genes, especially those encoding the muscle…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER96.3% of users find it useful
Research Ppaer with draft
Read TextPreview

Extract of sample
"Ppaer with draft"

Download file to see previous pages Since gene mutations primarily cause the condition, attempts to develop gene and cell therapies provide a possible cure for the various types of Muscular Dystrophies. However, gene and cell therapies come with several challenges, especially since the skeletal muscle is the most abundant in the human body.
Gene therapy involves gene replacement or modification. As a result, the need to find an efficient method to deliver the new gene to the body becomes of paramount importance. One of the challenges facing gene therapy is the packaging of genes. For example, dystrophin, whose defects are responsible for DMD and Becker MD. Dystrophin is larger than the packaging capacity of many vectors used in delivering the gene to the skeletal muscles. According to Chamberlain 2002, truncated versions of the dystrophin gene become the solution. Research shows that truncating the Central Rod and the C-terminal domains causes minimal changes on the functionality of the dystrophin gene. Shortened versions of the dystrophin gene tested on mice in preclinical studies provide positive results indicating that the micro-dystrophins reverse the abnormalities of the dystrophic muscle.(Cossu & Sampaolesi, 2007)
Gene therapy faces the challenge of identifying a favorable viral vector focusing on Adenoviral vectors (Ad), retroviruses and adeno-associated viruses (AAV). Ad vectors contain large capacity of cloning and efficiently infect the muscle. Development of the ‘gutted’ Ad tackles the problem of immune response triggered by the Ad vector. According to Chamberlain (2002), the gutted version contains the ability to package full-length cassettes of dystrophin. However, the Ad vector’s large size hinders diffusion in muscle tissue. Hence, Ad vector is not the best choice vector. Retroviruses posses small cloning capacity and hence are limited to the delivery of mini dystrophins. The most promising gene delivery vector proves to be adeno-associated virus (AAV). (Haidet, Mendell & ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Research Ppaer with draft Paper Example | Topics and Well Written Essays - 750 words - 1”, n.d.)
Research Ppaer with draft Paper Example | Topics and Well Written Essays - 750 words - 1. Retrieved from https://studentshare.org/biology/1619300-research-ppaer-with-draft
(Research Ppaer With Draft Paper Example | Topics and Well Written Essays - 750 Words - 1)
Research Ppaer With Draft Paper Example | Topics and Well Written Essays - 750 Words - 1. https://studentshare.org/biology/1619300-research-ppaer-with-draft.
“Research Ppaer With Draft Paper Example | Topics and Well Written Essays - 750 Words - 1”, n.d. https://studentshare.org/biology/1619300-research-ppaer-with-draft.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Research Paper Rough Draft
Many people in the societies were captured in the fear of witches, diabolic figures and other magic. Though beliefs in the existence
9 Pages(2250 words)Research Paper
Debate on Military Draft
All the young men are required to register with the Selective Service. The candidates present themselves before a vetting panel to assess if they are fit to join the military. There is no alternative in the issue, mainly, which is why this draft is so debatable when citizens who join the military will in fact be struggling for their country’s good at risk of their own life.
6 Pages(1500 words)Research Paper
Research Ppaer
Literature review on a research topic for identification of a problem statement, research methodology, procedure for implementing the methodology, data analysis, discussion of results, and conclusion are examples of elements and processes that develops a research paper.
4 Pages(1000 words)Essay
Research Paper Rough Draft
Attempts of intruders to hack networks can never be prevented therefore strengthening the network security features is the only choice. Conventional password securities can no longer withstand the exceedingly systematized attacks of hackers. In recent times
8 Pages(2000 words)Research Paper
Literature Review Rough Draft
A lot of research has been done in the past to find out optimal nursing staffing and the effects of understaffing on healthcare outcomes. This paper reviews literature to explore how the relationship between
3 Pages(750 words)Research Paper
Research Proposal Draft
However, as Bethell et al (2012) say, the problem is that there is few studies that have been done to indicate the connection between low body weight (Body Mass Index) and the positive health
3 Pages(750 words)Essay
According to the report social media has always been used by most organizations as a means of communicating with the masses as well as relating with the public or clientele served by the organization. The public relations endeavor must be capable of bringing together the internal and external functioning of the organization.
9 Pages(2250 words)Research Paper
Research paper draft 3
The Macondo is revealed as a biblical paradise. It is depicted as a town characterized merely the presence of the exterior world being the supernatural gypsies .On the other hand, the
7 Pages(1750 words)Research Paper
Research Paper Topic draft
In line with that, there are many other research topics within gender and sexuality that can be discussed. A good research topic concerning the gender and sexuality can be summed up as
1 Pages(250 words)Research Paper
Con For Military Draft
As a most powerful, most modern, and most compassionate nation, the US even in a state of emergency, should not choose to reinstate the military draft unless it has
6 Pages(1500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Research Paper on topic Research Ppaer with draft for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us