Facility design :Clean Room Reducing Level - Essay Example

There is intense pressure from the management to flatly reduce costs of this site or risk closure. The cost reduction option which was developed by the site team was to outsource three of the mature drugs from another BFT site located within the country and with lower labor rates. This was to be followed by downgrading both cleanrooms from class 100 to 1000. Furthermore, it was recommended that each cleanroom will only produce one new drug type at an increased rate that was not used before. Cleanroom is an environment that is completely controlled and where airborne particulates are regulated through an exchange of highly filtered air (1).

The air control is also regulated through minimization of activities which can literary generate particles. The room is used specifically for scientific research or production since the room has low levels of environmental pollutants (1). Class 100 cleanroom maintains less than 100 particles larger than 0.5 microns in each cubic foot of air space (1). It is also considered that class 100 is an equivalent of ISO class 5clean rooms (1). When it comes to the design difference between class 100 and 1000 clean rooms, it is evident that class 100 has unidirectional air flow system with average airflow velocity of 50-90 fpm (1).

The air change’s for class100 is counted to range between 300- 480 changes per hour (1). On the other hand, class 1000 has mixed type of air flow system with an average of 40-90 airflow velocity fpm and also possess between 150- 250 air changes per hour (1). The clean room class 1000 is ranked to an equivalent of ISO class 6 cleanroom. It is considered that the cleanroom capacity is wider to a maximum measurement of 600 square feet’s. In such capacity, the overall estimated level of particles harbored in the clean room is less than 1000 particles per cubic foot.

In addition to this, the particle control, the cleanroom has temperatures and