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Research Review Paper about Systemic Lupus Erythematosus - Book Report/Review Example

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Research Review on Systemic Lupus Erythematosus Name Subject Teacher Date               Research Review on Systemic Lupus Erythematosus Study Hypothesis Based on previous studies with systemic lupus erythematosus, or SLE, the disease is believed to be treated using drugs that suppress the immune system…
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Research Review Paper about Systemic Lupus Erythematosus
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Download file to see previous pages These specific methods include intense immunosuppression as well as the use of autologous hematopoietic stem cell support (Burt et al., 2006). Population A closed cohort population was utilized in the study. The 50 patients enrolled in the study had a characteristic SLE that did not respond to conventional or standard immunosuppressive therapy. Moreover, these patients had visceral involvement that threatened either a vital organ or their very lives. The single-arm trial of 50 patients were enrolled from April 1997 to January 2005 in a study where they had to undergo autologous nonmyeloablative hematopoietic stem cell transplantation, or HSCT, in one US medical center (Burt et al., 2006). Study Design Although the design of the study is not clearly specified, it is obvious that what is utilized in the study is both an experimental and an observational approach. The study is a single-arm trial of 50 patients who had a treatment-refractory form of systemic lupus therapies as well as an impairment in the visceral area for other organs. The patients were actually enrolled in the program from April 1997 to January 2005, and thus had to undergo not only intense medication therapy but also an autologous nonmyeloablative hematopoietic stem cell transplantation or HSCT (Burt et al., 2006). ...
Secondary data which were measured immediately upon admission into the experimental study included the Systemic Lupus Erythematosus Disease Activity Index, or SLEDAI, the lupus serology test results as determined by the antinuclear antibody and anti-double-stranded DNA antibody, the test on complement C3 and C4, and the test on end-organ function determined by creatinine clearance, and the carbon monoxide diffusion lung capacity. Immunofluorescence was used to measure the determinants of the lupus serology tests (Burt et al., 2006). The study is also a longitudinal study because of the daily administrations of drugs that helped initiate leukapheresis. The mobilization of peripheral blood stem cells were triggered by the administration of cyclosphamide at 2.0g/m2 as well as the granulocyte colony-stimulating factor, or G-CSF, at 5 µg/kg per day. Both drugs were administered cutaneously 3 days after the study began (Burt et al., 2006). After the initial mobilization of the peripheral blood stem cells and 14 days after stem cell apheresis, the conditioning regimen was administered and consisted of 50 mg/kg daily administration of intravenous cyclosphamide and 30 mg/kg daily administration of intravenous equine ATG. The total of 200 mg/kg of intravenous cyclosphamide was given 5, 4, 3 and 3 days before transplantation, while the total of 90 mg/kg of intravenous equine ATG was given 4, 3 and 2 days before transplantation (Burt et al., 2006). Another reason why the study was a longitudinal study was that there was antibiotic prophylaxis or an antibiotic regimen that was required before patients had to undergo stem cell transplantation. This antibiotic regimen consisted of HSCT aerosolized pentamidine (300 mg/daily), fluoroquinolone in the form of levofloxacin and ...Download file to see next pagesRead More
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