Comprehensive High-Throughput Arrays for Relative Methylation - Article Example

The paper “Comprehensive High-Throughput Arrays for Relative Methylation and Cancer Genetics, Epigenetics - Two Sides of the Same Coin" is a spectacular example of a literature review on science. Respectively, the authors commented that genetic alteration and epigenetic has been considered as two different mechanisms contributing to carcinogenesis.

However, their recent study revealed that these two genetic factors in the field of carcinogenesis are the same. The article of Irizarry, Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen, and Feinberg (780) suggested that their research objective of discovering the effective tool to identify the genomic locations has been a major success in the field of genetic alteration and epigenetic. This new tool shows nearly ‘100% sensitivity at 90% specificity with McrBC’. In addition, the new tool is termed as ‘Comprehensive high-throughput arrays for relative Methylation’ (CHARM).

IMPORTANT CONCLUSIONS The study of You and Jones (9) in the field of carcinogenesis and genetics revealed that cancer genetics and epigenetics are the same. The authors further conclude that genetic alteration, which is not inherent to the next generation, is the major factor that leads to the formation of carcinogenic cells or cancer. A similar cause is also notable from the epigenetic process that leads to mutation of the cells and finally causes cancer. In the experimental study of Ladd-Acosta, Carvalho, Wu, Brandenburg, Jeddeloh, Wen, and Feinberg (780), a major conclusion has been drawn with regard to the effectiveness of CHARM.

CHARM is highly effective in determining genomic locations. The effectiveness of the tool is evident from the high sensitivity and specificity in identifying the locations of the genomes. Moreover, the researchers concluded that CHARM is a relatively inexpensive tool and is highly effective in determining genome width. Furthermore, the researchers determined that individual sample analysis could be executed with the assistance of this tool, wherein the sample has a high density. Evidence FOR CONCLUSIONS There is certain research evidence based upon which You and Jones (9) concluded their findings.