Nobody downloaded yet

Holger Heyn et al. Distinct DNA methylomes of newborns and centenarians PNAS 2012 paper and answer the following questions - Assignment Example

Comments (0) Cite this document
Human aging as a topic was the main factor that led to the purpose of this study which was to establish if the DNA methylomes in newborns are different in older people those aged and in between old age and newborns. The main finding of the study was in terms of the number of…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER97% of users find it useful
Holger Heyn et al. Distinct DNA methylomes of newborns and centenarians PNAS 2012 paper and answer the following questions
Read TextPreview

Extract of sample
"Holger Heyn et al. Distinct DNA methylomes of newborns and centenarians PNAS 2012 paper and answer the following questions"

Download file to see previous pages target points in the experiment not only because they contain methyl groups but also the researchers wanted to strengthen the study through CpG results, because they make the DNA strands which happen to play a crucial role in human aging. In relation to methylation, CpG regions tend to have a high content of methylomes hence were the most suitable for the study.
3. 12- 16 Whole Genome bisulphite sequencing of all the samples: newborn, centenarian and intermediate, was done to identify the methylation status. Also, a microarray of 450000 CpG methylation samples were included in the experiment. WGBS was hence performed for all the samples. For the newborn, fresh cord blood with permit from the parents was acquired for the experiment while for the old age his CD4 positive T cells were used. The intermediate sample was from a twenty six year old. All the three samples were from Caucasian males.
4. The methylation status in the three samples was different but formed a final curve in the results. The centenarian DNA had low methylomes compared to those in a newborns DNA. Moreover, there is very low correlation in methylation of the CpG positions that are near the DNA. The intermediate sample was between the two, meaning is was second in the level of methylation. The CpG that were densely methylated in centenarian sample were located in specific genomic regions such as the promoters and more were on Island promoters than the poor promoters.
5. Alternative methods used apart from WGBS included the determination of the DMRS which are the differentiated methylated regions in the DNA of the two main samples. This method involved checking the total length of identical CpGs in the two samples by counting those that have a continuous consistent flow of methylation status. Moreover, an identified map of CpG that showcases a microarray of the 450000 samples use. The results from the map were then compared to those from WGBS.
6. The six genes from WGBS that were identified as ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Holger Heyn et al. Distinct DNA methylomes of newborns and Assignment”, n.d.)
Retrieved de https://studentshare.org/biology/1680398-holger-heyn-et-al-distinct-dna-methylomes-of-newborns-and-centenarians-pnas-2012-paper-and-answer-the-following-questions
(Holger Heyn Et Al. Distinct DNA Methylomes of Newborns and Assignment)
“Holger Heyn Et Al. Distinct DNA Methylomes of Newborns and Assignment”, n.d. https://studentshare.org/biology/1680398-holger-heyn-et-al-distinct-dna-methylomes-of-newborns-and-centenarians-pnas-2012-paper-and-answer-the-following-questions.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Answer ONE of the following questions
Before, expressing any one view it is necessary to consider the different school of thoughts. This consideration will aid in forming and expressing an opinion that will have firm bases. Before the essay progresses it is imperative to shed light upon the background of religion as per the historians and writers alike.
6 Pages(1500 words)Assignment
Answer the following Marketing Discussion Questions
A comprehensive marketing is a sequential planning process which consists of seven components. The first step is the composing of an executive summary which provides with an overview of the marketing plan. The second step is the situational analysis which summarizes all relevant information collected from the internal environment, the customer environment and the form’s external environment.
2 Pages(500 words)Assignment
Drawing from key readings (e.g., Chandler, 1990 Hoskin et al, 2006 Drury, 2012) and your answer in part a) and part b), critical
In most cases, these external parties do not have unlimited access to these information that is considered to be internal to the organization (Chandler, 1990 pg 7). They are also not in a position to specify what information will be presented to them. Instead, these external parties have to rely on the general reports that are presented to them by the companies.
4 Pages(1000 words)Essay
Answer the following questions
handle all phases of import and export documentation, including but not limited to: calculating freight, storage and other related charges; preparing documents for next sector transfer, delivery and other related cargo handling phases, such as preparing cargo manifests. One of
1 Pages(250 words)Essay
GEOL : Assignmen-- Answer all following questions:
2. If sedimentary layers (beds) are steeply inclined in an exposure (outcrop) of rock, the principle allows you to assume that the beds were tilted after they were deposited is the Principle of Original
2 Pages(500 words)Assignment
No topic, just answer the following questions
Seminiferous tubules act as a site of sperm production within the testicles. In the tubules, there is partial development of the cells. Hence, the sperm needs another place to develop fully. As a result, partial developed sperm moves
7 Pages(1750 words)Assignment
Answer the following questions
In the life of all the people language and communication play an essential role, thus teachers try to make the process of language learning less complicated and more efficient. While looking for the ways to improve language learning process, it is important for instructors to consider Halliday, who called the learning of language the learning of meaning.
10 Pages(2500 words)Assignment
Answer following questions
They thereafter set out top disarmer the general public in an exercise that was not at a very peaceful encounter. Those who came on the way of the force
5 Pages(1250 words)Assignment
Answer the five following questions
The spokesman in the advertisement is an expert in the field considering the manner in which they bring out the liveliness and reality in the pictures. The intention of the spokesman is therefore to capture the imagination of the audience
1 Pages(250 words)Assignment
Please answer the following questions
These structures are based on departments and functional divisions that exist. They follow t he rules and regulations of the organizations. This includes line structure which is specific in line of command. Line and staff structure which is
2 Pages(500 words)Assignment
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Assignment on topic Holger Heyn et al. Distinct DNA methylomes of newborns and centenarians PNAS 2012 paper and answer the following questions for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us