Contact Us
Sign In / Sign Up for FREE
Go to advanced search...

Systemic Lupus Erythematosus - Essay Example

Comments (0) Cite this document
The paper “Systemic Lupus Erythematosus” looks at a remarkable disease in many aspects; the primary being it is not a single but a protean disease, affecting almost every organ of the body. The disease is fatal and is manifested in form of multiple clinical symptoms…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER98.4% of users find it useful
Systemic Lupus Erythematosus
Read Text Preview

Extract of sample "Systemic Lupus Erythematosus"

Download file to see previous pages However, the disease epidemiology is incompletely understood (Rahman & Isenberg, 2008). The disease involves the production of IgG autoantibodies that are specific for self-antigens including DNA, nuclear proteins as well as cytoplasmic components. The disease, therefore, is characterized by inflammation, vasculitis, vasculopathy. Further, a deposition of the immune complex especially in the renal glomeruli leads to a systemic inflammatory response through activation of complement (C5), or of Fc{gamma}R-mediated neutrophil and macrophages. While the activation of former leads to the formation of membrane attack complexes (C5b-9) or anaphylatoxin and cell activator C5a; that of latter causes release of oxidants and proteases; both leading to injury (KEGG, 2009). The mechanism of the disease development has been proposed to involve an abnormal apoptosis followed by elevated levels of cell death and immune intolerance. Cellular antigen redistribution to the cell surface coupled with lymphocytes targeting them leads to injury and inflammation (Andrade et al., 2000). Treatment Diagnosis of SLE is based on the detection of high levels of antinuclear and other antibodies in the blood along with symptoms of SLE. The techniques used for the detection include urinalysis, CBC, ESR, complement levels, ANA (antinuclear antibody test) and other antibody tests, skin and kidney biopsy along with quarterly follow-ups. The treatment involves control of disease symptoms and is determined by the severity of the symptoms. Acute SLE involving CNS, cardiovascular and renal diseases are treated with high doses of intravenous steroids and cytotoxic therapy involving corticosteroids, immunosuppressives, antimalarials, and antipsychotic medication (D’Cruz, 2006). Prognosis Early detection is the key factor in the improved prognosis of SLE. Prognosis in severe cases to has shown marked improvement during the recent years as a consequence of aggressive treatments available. Common complications associated with SLE include deep vein thrombosis, pulmonary embolism, hemolytic anemia, pericarditis, endocarditis, myocarditis etc (Makover, 2011). Health Disparity SLE exhibits high correlation with women of childbearing age and therefore has been associated with exogenous hormone intake (Costenbader et al., 2007). Lower socioeconomic status further has been linked to higher disease prevalence as well as resultant mortality. Prevalence and Epidemiology The National Arthritis Data Working Group reports that approximately 250,000 Americans have SLE, the worldwide prevalence rates vary with race, being higher in people with African and Asian origins. The disease is more common in the female sex and in individuals within the age group of 20-40yrs. (D’Cruz, 2006). ...Download file to see next pages Read More
Cite this document
  • APA
  • MLA
(“Systemic Lupus Erythematosus Essay Example | Topics and Well Written Essays - 1750 words”, n.d.)
Retrieved from
(Systemic Lupus Erythematosus Essay Example | Topics and Well Written Essays - 1750 Words)
“Systemic Lupus Erythematosus Essay Example | Topics and Well Written Essays - 1750 Words”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Systemic Lupus Erythematosus

Money and capital Markets. Evaluate the potential and possible consequences of a systemic financial crisis

...Topic: Money and capital Markets. Evaluate the potential and possible consequences of a systemic financial crisis Introduction This paper seeks to analyze and discuss the potential and possible consequences of a systemic financial crisis? In this paper we will address the issues on whether the UK stock market is overvalued. We also see the application of the following theories such as Gordon growth model, p/E ratio, Tobins q and Efficient market hypothesis by critically evaluating these models in terms of relevancy to the issue of overvaluation of the stock market. The last part of paper decides whether there is truth to overvaluation and whether said overvaluation is true. It must be stated the paper will address the problems in UK...
20 Pages (5000 words) Essay

Systemic Lupus in Psychology

... The purpose of this essay is to study of systemic lupus (or lupus). The disease has physiological as well as psychological impact on the afflicted individuals. An examination of causes, symptoms and treatment of lupus helps to understand the physiological impact of the disease, while looking at families coping with, the psychological aspects. By focusing on these aspects of lupus, one is fully aware of the effects of lupus. A study of the available research materials indicates that a lot more information is needed to combat the disease. Given the severity and debilitating effects of lupus, further research is imperative. Unlike most common illness such as flu or asthma, their diagnosis is rather simple in comparison. In the case...
2 Pages (500 words) Essay


.... Neonatal Lupus s a rare type of Lupus that specifically affects newborns. Drug-Induced Lupus is, also, relatively rare. Unlike other forms of Lupus, whose origins and causes cannot be easily determined, is directly caused due to a side-effect of certain medications. Subacute cutaneous lupus erythematosus results specifically in skin sores in areas of skin exposed to sunlight. Discoid lupus erythematosus presents as a perpetual skin rash, however, it is systemic lupus erythematosus or SLE that is the most common and the most systemically damaging in that it affects multiple systems including joints, skin and internal organs. When people refer to Lupus it is this type that they are most often referring to (National Institute of Arthritis...
5 Pages (1250 words) Essay

Unit III Assessment #2 Systemic Effects

...SYSTEMATIC EFFECTS OF AIR POLLUTION IN URBAN INDIA SUMMARY of Human activities cause global air pollution leading to respiratory and cardiovascular diseases in urban India. Cardiovascular changes The changes experienced in the cardiovascular and air pollution relate intimately. Cardiac inefficiency, myocardial infarction, angina and hypertension are in increase globally due to air pollution. In 1997, pollution-related respiratory diseases caused 8.5% deaths while cardiovascular contributed 39.5% of the total deaths in the United States. Compared to respiratory diseases, cardiovascular ailments are important causative of death due to exposure to polluted air. In urban India, risks and deaths due to cardiovascular ailments occur... EFFECTS OF...
1 Pages (250 words) Essay

Systemic Racism A Theory of Oppression

...Racism Contents Introduction 3 Discussion 3 Conclusion 6 References 7 Introduction The term ‘racism’ refers to discrimination and prejudice that is based on some form of social perceptions that is acquired through biological differences between individuals. Racism often results into some kind of social actions political systems, beliefs and practices that consider different races on basis of rank where one individual is treated to be superior while the other to be interior. Though in certain parts of the world the concept of racism has totally faded but in some regions it still exists. The concept of racism has its origin from the historical times and it affects different people differently. In context of history the factor of racism...
5 Pages (1250 words) Research Paper

Critique of Systemic Research Review (SRR): Preventing Ventilator Acquired Pneumonia in The Acute Care Setting

...Preventing Ventilator Acquired Pneumonia in the Acute Care Setting Systematic Research Review Introduction Pneumonia refers to inflammation that occurs at the lungs due to irritation by chemical substance, bacteria, virus, fungi or an aspirate. Pneumonia can either be community acquired or nosocomial in nature. In the hospital setting, patients can be able to get pneumonia from nosocomial infections, mechanical ventilators or during aspirations in anesthesia. Quite a number of studies have been on going in regard to ventilator acquired pneumonia which is commonly due to aspiration. In a research conducted by Methenyl et al (2010) to find out whether elevation of the head had an impact on a critical ill patient on mechanical... Ventilator...
5 Pages (1250 words) Research Paper

Potential and Possible Consequences of Systemic Financial Crisis

...Running Head: Financial Crisis Potential and Possible Consequences of Systemic Financial Crisis of the of the A) Introduction Financial crisis, like any crisis situation, is the instability and uncertainty found in the money and capital markets. Systemic financial crisis is primarily due to the systemic risks inherent in the investment and trade activities of these financial markets. Such risks are pre-existent and their serious and critical effects come into play only if these are triggered by an external event(s), which may include economic downturn, exchange rate changes, global or international financial crisis, a central corporate or institutional collapse or even a major market player’s personal financial downturn or insolvency...
20 Pages (5000 words) Essay

A Systemic Inquiry as a Research Process

... A Systemic Inquiry as a Research Process Journal 1 Module 1 1. Research Process The activities involved in a systemic inquiry into any phenomenon or topic is called research process. It is difficult to describe research process in one word. However, in broader terms, research process is a step-by-step process to create a research project. The very need for any research begins with a question which relates to a gap in the existing knowledge. Thus when a question arises, the process of finding an answer to it in a rational manner with a clear objective and goal for the research can be termed as research process. Describe the Research Wheel Research wheel is a pictorial description of different phases of the research process. By the use...
53 Pages (13250 words) Assignment

Systemic Functional Analysis of the book of Job

... the times of tribulations. This paper is a presentation of the book of job, as a linguistic feature. The paper entails a systemic functional analysis of the book. 1. Analysis The analysis of the text in the book of job will take the form of experiential meaning to demonstrate the way grammar can be used to express experience. This essay will analyse the text using some of the grammatical systems such as transitivity, mode, aspect or mood. Thereafter, the essay will attempt an interpretation of the text using the SFG literature. The book of job will form the basic text of analysis using the systemic functional linguistics. Systemic functional linguistics studies language in reference to the society. The book of job is an authentic product...
14 Pages (3500 words) Assignment

Emerging Systemic Risks

... of Europe, emergency of infectious diseases, devastating bush fires in countries such as Australia and the ice storms in Canada among others. These aspects have made governments and the private sector to realize that something is happening. The emerging risks have the potential for inflicting immense damage on the infrastructure and systems upon which the economies and societies depend. Further, these emerging risks have created difficulties for traditional risk management strategies to work. It has also become a challenge for government entities and private sectors to effectively deal with the complex security threats of this century (Johnson, 2003). Various researchers have conducted studies on the topic of “Emerging risks...
8 Pages (2000 words) Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Systemic Lupus Erythematosus for FREE!

Contact Us