IgG Deficiency and Sinusitis - Essay Example

The T cells help in B cell immunoglobulin synthesis. Thus, selective IgG deficiency is accompanied by isolated IgG deficiency with normal levels of IgA, IgM, IgD, and IgE. In specific IgG deficiency, there is evidence of inadequate levels of other immunoglobulin isotypes. Both types of IgG deficiency result in respiratory infections. For instance sinus, ear, pneumonia, and bronchitis infections. In this case, the patient is diagnosed with a combined T and B cell immunodeficiency (Lang, 2009. This individual is suffering from IgG2 due to the developing illnesses of the sinus (Porth, 2011).

In addition, the antibodies against polysaccharide antigens and carbohydrates belong to the IgG2 category. On the other hand, antibodies against protein antigens are categorized in IgG1 and IgG3 groups. Patient education. The IgG immunoglobulins are categorized into four groups founded on their function and structure. It is classified from IgG1 to IgG4. In most cases, about 70% fit in the IgG1 and 20% belong to IgG2 groups. Antibodies that are opposed to protein antigens fit in the IgG1 and IgG3 groups. There is another class of antibodies that are opposed to polysaccharides and carbohydrates antigens that belong to the IgG2 group.

Patients with IgG2 deficiency are at high risk of suffering from pneumonia, otitis media, and sinusitis. These illnesses are triggered by microorganisms known as polysaccharide-encapsulated. The microorganisms include N. meningitides, H. influenza type b, and pneumonia. In some cases, the patients are healthy, and others are asymptomatic in presence of the IgG deficiency (Burmester & Pezzutto, 2011). The recommended therapy consists of prophylactic antibiotic treatment. In addition, gamma-globulin replacement is offered in case of recurrent infection (Mandell, Woodhead, Ewig & Torres, 2006).

All in all, the cause of IgG deficiency is not known but in some cases, immunoglobulin synthesis disorders are inherited. A novel advancement in IgG deficiency treatment is polysaccharide vaccines that are related to protein carriers. These vaccines are used to give the defense against some of the respiratory infections triggered by IgG deficiency. Moreover, as a precaution, it is not advisable to use protein related to protein carriers because it triggers IgG1 reaction (Porth, 2011). Concept map of IgG deficiency inability to form specific recognition structures i.e. immunoglobulins for humoral immunity and T- cell receptions for cellular immunity OR Abnormal production of B & T cells.