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Sinusitis - Essay Example

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The IgG deficiency can have an impact on one or more categories of the IgG in spite the serum level of concentration. This paper will discuss the pathophysiology of IgG deficiency and…
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Download file to see previous pages... Thus, there is the abnormal production of B and T cells, and IgG deficiency is triggered by a defect of B cells. IgG deficiency can occur in two forms that are selective and specific. In most cases, the B cells are low in selective antibody deficiency. Likewise, the T cells are also inadequate. The T cells help in B cell immunoglobulin synthesis. Thus, selective IgG deficiency is accompanied by isolated IgG deficiency with normal levels of IgA, IgM, IgD, and IgE. In specific IgG deficiency, there is evidence of inadequate levels of other immunoglobulin isotypes. Both types of IgG deficiency result to respiratory infections. For instance sinus, ear, pneumonia, and bronchitis infections. In this case the patient is diagnosed with a combined T and B cell immunodeficiency (Lang, 2009. This individual is suffering from IgG2 due to the developing illnesses sinus (Porth, 2011). In addition, the antibodies against polysaccharide antigens and carbohydrates belong to IgG2 category. On the other hand, antibodies against protein antigens are categorized in IgG1 and IgG3 groups.
The IgG immunoglobulins are categorized in four groups founded on the function and structure. It is classified from IgG1 to IgG4. In most cases, about 70% fit in the IgG1 and 20% belong to IgG2 groups. Antibodies that are opposed to protein antigens fit in IgG1 and IgG3 groups. There is another class of antibodies that are opposed to polysaccharide and carbohydrates antigens that belong to IgG2 group. Patients with IgG2 deficiency are at high risk of suffering from pneumonia, otitis media, and sinusitis. These illnesses are triggered by microorganisms known as polysaccharide-encapsulated. The microorganisms include N. meningitides, H. influenza type b, and pneumonia. In some cases, the patients are healthy, and others are asymptomatic in presence of the IgG ...Download file to see next pagesRead More
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