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Give an illustrated desription of the structural and functional specialisations of the intermediate cells in stria vascularis, and discuss how these cells contribute to the generation of endolymph and the endocochlear potential - Essay Example

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Stria vascularis produces scala media endolymph, one of the 3 fluid-filled partitions of cochlea. The stria is somewhat…
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Give an illustrated desription of the structural and functional specialisations of the intermediate cells in stria vascularis, and discuss how these cells contribute to the generation of endolymph and the endocochlear potential
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Extract of sample "Give an illustrated desription of the structural and functional specialisations of the intermediate cells in stria vascularis, and discuss how these cells contribute to the generation of endolymph and the endocochlear potential"

Download file to see previous pages The basal cells isolate stria vascularis from the fundamental spiral ligament. Stria vascularis also encompasses pericyte, melanocyte and cells. It is the only the epithelial tissues that are not avascular (completely lacks lymphatic and blood vessels) (Clark & Ohlemiller, 2008, p. 32). This paper explores the structural and functional specializations of the intermediate cells in stria vascularis, and discusses how these cells contribute to the generation of endolymph and the endocochlear potential (EP).
The endolymph in the ear cochlea is a unique extracellular fluid since its predominant cation is K1 while its electrical potential (endocochlear potential, EP) is 80 to 90 mV positive in relation to the perilymph. The EP together with the high concentration of K1 in the endolymph is vital for the sound transduction by hair cells. Sound transduction begins at the hair cilia cells, which allow mechano-electrical transducer channels which are contacted with the endolymph. Whenever the transducer channels open, the K1 ions flow into the hair cells. The main dinitiator for the K1 influx to the transducer channels is electrical gradient across the cilliary membrane produced by the summation of the EP and resting hair cells membrane potential (Clark & Ohlemiller, 2008, p. 13).
It has been acknowledged that stria vascularis in cochlea produces the EP and the endolymph, but a general settlement on the mechanism tangled in EP production has never been reached. Within stria vascularis are the intermediate cells, melanocytes, and migrate from neural crest during ontogeny. It is identified that a congenital insufficiency in these cells leads to low EP levels and an increased threshold levels of sound pressure required in eliciting compound action potentials.
Resulting hair cell transduction, the latent perilymphatic [K+] is increased locally by 3 mM the underlying Deiters’ cells offer an essential homeostatic yaske by “siphoning” excess K+, ...Download file to see next pagesRead More
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