Sickle cell anemia - Essay Example

Comments (0) Cite this document
Summary
Also called sickle cell disease, this illness is the result of a genetic mutation that originally occurred in direct response to…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER93.8% of users find it useful
Sickle cell anemia
Read TextPreview

Extract of sample "Sickle cell anemia"

Download file to see previous pages value to carrying a single sickle-cell gene in these areas because people with only two alleles of the gene are much less likely to fall victim to malaria (Kwiatkowski, 2005). The condition is characterized by the shape of the individual’s red blood cells, which tend to adopt a rigid, abnormal ‘sickle’ shape to them that decreases the cell’s flexibility and can create a number of complications throughout the body as a result. This occurs as a result of a mutation in the hemoglobin gene and it affects approximately 1 in 5,000 Americans, most of who are of African American descent. The life expectancy for people with sickle cell anemia is shorter than normal averaging 42 for men and 48 for women (Platt, Brambilla & Rosse, 1994). The purpose of the present research is to identify the genetic origins of this illness and the affects it can have upon the body.
There are a number of different forms of the disease which are classified based upon the mutations present within the blood. Sickle cell anemia is the term used to specifically apply to those individuals who present homozygosity for the mutation (Green et al, 1993). In these individuals, long-chain polymers of HbS have the effect of changing the normally smooth, donut-like shape of the red blood cells to a more spiked and rigid shape that makes the cell more susceptible to breakage. People who are heterozygous for the illness are generally carriers, having only one sickle gene and one normal gene that generally makes up for the deficits of the sickle gene. However, when the ‘normal’ gene is also abnormal in some way, other forms of the illness can manifest, typically referred to as compound heterozygous (Green et al, 1993). The sickling effect is caused by a point mutation in which the glutamic acid, a type of amino acid, is replaced with valine, a hydrophobic amino acid, at the sixth position. When in low oxygen conditions such as being at a high altitude, this causes an aggregation of ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Sickle cell anemia Essay Example | Topics and Well Written Essays - 1250 words”, n.d.)
Sickle cell anemia Essay Example | Topics and Well Written Essays - 1250 words. Retrieved from https://studentshare.org/miscellaneous/1557562-sickle-cell-anemia
(Sickle Cell Anemia Essay Example | Topics and Well Written Essays - 1250 Words)
Sickle Cell Anemia Essay Example | Topics and Well Written Essays - 1250 Words. https://studentshare.org/miscellaneous/1557562-sickle-cell-anemia.
“Sickle Cell Anemia Essay Example | Topics and Well Written Essays - 1250 Words”, n.d. https://studentshare.org/miscellaneous/1557562-sickle-cell-anemia.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Sickle cell anemia

Sickle cell anemia

...? Sickle Cell Anaemia Task Chapter 4 Sickle cell anaemia is a disease that is genetic and one that leads to blood disorder and usually transferred during birth. Several factors indeed affect pregnant women who have the sickle cell trait or who have the disease and the factors are, fear anxiety and level of education. Most pregnant women fear telling their husbands that they should go, be screened, and would rather give birth to children who have sickle cell anaemia. The contributory factor to sickle cell anaemia is the fact that most people lack education about the disease and so are not aware about it. Most people do not know the difference between the sickle cell disease and the sickle cell trait and instead they ignore all... this and...
10 Pages(2500 words)Research Paper

Sickle cell anemia

...? Sickle Cell Anemia INTRODUCTION “Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal crescent shape. It is caused by an abnormal type of hemoglobin called hemoglobin S” (Sickle cell anemia, 2011). Hemoglobin is an iron-rich protein and an important component of blood. It is the oxygen carrier in blood. In other words, Hemoglobin is responsible for distributing oxygen to different body organs. It should be noted that adequate oxygen supply is necessary for many of the body organs to function well. So any defects occur to...
4 Pages(1000 words)Research Paper

Sickle Cell Anemia

...25th December SICKLE CELL ANEMIA Sickle cell anemia is a disease that is categorized at the molecular level. It is an inherited disease which can be passed on from generation to generation from both the parents. The term sickle cell comes from the sickle shape or the crescent type shape of the affected hemoglobin molecules. It is caused due to a change in just a single nucleotide in a DNA molecule out of a billion others present in the cells of the human body. It may seem like a minor change but the effect is disastrous. Each cell of a human body...
6 Pages(1500 words)Essay

Sickle Cell Anemia

...? Sickle Cell Anemia Sickle cell anemia is a genetic disease which is inherited, and can be passed down several generations through both the parents. The term ‘sickle cell’ comes from the sickle shaped or crescent shaped form of the hemoglobin molecules. This sickling of the cells is caused due to a change in one of the nucleotides of a DNA molecule out of the billion other cells present in the human body. This change may seem minor, but the results are disastrous. A person affected with sickle cell anemia inherits a mutated or recessive allele from both the parents. Therefore the patient contains faulty hemoglobin in the red blood cells, which causes the cells to become deformed and sickled when oxygen levels in the blood get low... ...
3 Pages(750 words)Essay

Sickle Cell Anemia in Adults

...Sickle Cell Anemia in Adults Abstract Sickle cell anemia or sickle cell disease is a pathological condition that manifests in early infancy. The condition is associated with morbidity and mortality and many children succumb to its complications in childhood and adolescence. Some of them enter into adulthood and suffer from chronic complications related to chronic hemolysis, recurrent infarctions, chronic organ disease and chronic pain. The dreaded complication of the disease in adults are infarction crises which can manifest as dactylitis, femoral head necrosis, acute abdomen, hematuria and stroke. The...
7 Pages(1750 words)Research Paper

Sickle Cell Anemia

...1 Sickle Cell Anemia Proposal for funding "Sickle Cell Anemia is the most common inherited blood disorder in the United s. Affecting about 72,000 Americans or 1 in 500 African Americans". (SCDAA 2005) "Contrary to the view in western science that Sickle Cell Anemia is mostly a black people's problem, Fr. Oji Abai, a Nigerian researcher living in the United States, has shown that Sickle Cell Anemia is found in all races. On a per capita basis, it is most prevalent in Greece". (Henry) "Sickle Cell Anemia is characterized by episodes of pain, chronic hemolytic anemia, and severe infections, usually beginning in early childhood". (SCDAA) "The most common form of (SCA) found in North America... for males...
3 Pages(750 words)Essay

Sickle-Cell Anemia

...Sickle-cell Anemia Introduction: Sickle-cell anemia is a term that de s a group of genetic disorders caused by sickle shaped hemoglobin Hgb S or Hb S. In patients with this disease the human red blood cells take a different shape upon deoxygenation because of polymerization of the abnormal sickle hemoglobin. This process causes damage to the red blood cell membrane and sometimes the red blood cells get attached in blood vessels. This attachment or adherence of the red blood cells deprives the tissues of oxygen causing ischemia and...
8 Pages(2000 words)Assignment

Sickle Cell Anemia

... Sickle Cell Anemia Sickle cell anemia is a genetic disorder that affects more than seventy thousand Americans and millions more people worldwide (Centers for Disease Control and Prevention). It is highly prevalent in populations of African descent (Ashley-Koch, Yang and Olney). The more common symptoms of the disease are related to anemia and pain (National Heart Lung and Blood Institute). Fatigue, shortness of breath, chest pain, pale complexion, headache, and dizziness are the symptoms that are related to anemia. Sudden and acute pain symptoms occur when the sickled red blood cells clump together in the bloodstream and block blood flow in the limbs. This pain can last from several hours to days. Chronic pain,lasting for weeks... and...
4 Pages(1000 words)Term Paper

Sickle cell anemia

...Sickle cell anemia (SCA) Sickle cell anemia Sickle cell anemia (SCA) comes in a varied array of forms of sickle cell illness, andit is genetic blood disorder which is mostly found in the United States. This disease mostly affects the African Americans where there are about 1500 people admitted due to this disease annually (Geller, 2009). Around 70,000 people, who are from sub African, even though there are some reports in India, some parts of central and South American areas, southern parts of Europe, and Caribbean regions mostly experience...
2 Pages(500 words)Research Paper

Sickle Cell Anemia

...Sickle Cell Anemia Single cell anemia is a hereditary disease that often characterized with abnormal red blood cells assuming rigid sickle shapes instead of the normal biconcave shape. The condition normally results in severe symptoms including anemia, pain and various life threatening complications associated with decreased flexibility of red blood cells. Sickle anemia is particularly caused by the mutation of a gene that is responsible for making hemoglobin proteins that carry oxygen in the red blood cells. Individuals with one copy of...
6 Pages(1500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Sickle cell anemia for FREE!

Contact Us