Nobody downloaded yet

Pathophysiology of Sickel Cell disease - Research Paper Example

Comments (0) Cite this document
Summary
As a child, my whole life changed as I had to “live” for her. I stayed by her side rubbing her joints as I watched her cry in excruciating pain and this always put me in a state of empathy. For the…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER93.5% of users find it useful
Pathophysiology of Sickel Cell disease
Read TextPreview

Extract of sample
"Pathophysiology of Sickel Cell disease"

Download file to see previous pages It results from homozygosity for a mutation in the beta globin gene and is transmitted by autosomal recessive inheritance (Passarge, 2007). A single nucleotide polymorphism (SNP) occurs in the beta globin chain, which results in the substitution of the amino acid residue glutamine at position 6 for valine. An individual may have one such abnormal gene and another normal gene and is said to be heterozygous. When a couple that is heterozygous for HbS give birth to children, there is a likelihood of one or more of the children inheriting these HbS genes from each of the parents. When this happens, the child has both HbS genes and is said to be homozygous for HbS. This is when a child suffers from sickle cell disease.
This disorder has potentially serious complications and early medication (prior to the development of symptoms) can advance morbidity and mortality. It affects hemoglobin, a protein that is part of red blood cells, which is responsible for oxygen transport. It is characterized by the presence of sickle cells in the bloodstream, which is also known as erythrocyte sickling. This causes difficulties in circulating red blood cells as the blood vessels get clogged and cause symptoms such as pain in the extremities (Gordon, 2000).
This disorder develops within the first 2 years, and the symptoms can be traced back to two main phenomena which are hemolysis and clots. Hemolysis causes chronic anemia, jaundice, lack of growth and sexual maturation. The vascular occlusions cause crisis musculoskeletal pain, increase susceptibility to bacterial infections (S. pneumonia, K. pneumonia, Homophiles influenza, etc.), cerebral infarction, and renal impairment.
As a consequence of the mutation, when the hemoglobin is deoxygenated, it spontaneously undergoes polymerization to form a crystalline gel. Each polymer is composed of longitudinal beams 14 of deoxy-Hb which are arranged to form a tactoid body, insoluble and rigid ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Pathophysiology of Sickel Cell disease Research Paper”, n.d.)
Pathophysiology of Sickel Cell disease Research Paper. Retrieved from https://studentshare.org/nursing/1610362-pathophysiology-of-sickel-cell-disease
(Pathophysiology of Sickel Cell Disease Research Paper)
Pathophysiology of Sickel Cell Disease Research Paper. https://studentshare.org/nursing/1610362-pathophysiology-of-sickel-cell-disease.
“Pathophysiology of Sickel Cell Disease Research Paper”, n.d. https://studentshare.org/nursing/1610362-pathophysiology-of-sickel-cell-disease.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
Sickle cell disease
...and treatment of sickle cell disease. New England Journal of Medicine, 337, 762-769 Christensen, R. (2002). Plane Answers to Complex Questions: The Theory of Linear Models (Third ed.). New York: Springer Claster, S., & Vichinsky, E. P. (2003). Managing sickle cell disease. British Medical Journal, 327, 1151-1155. Edwards, C. L., Scales, M. T., Loughlin, C., Bennett, G. G., Harris-Peterson, S., De Castro, L. M., et al. (2005). A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease. International Journal of Behavioral Medicine, 12, 171-179. Elander, J., Lusher, J., Bevan, D.,...
20 Pages(5000 words)Research Proposal
Sickle cell disease
.... L. (2001). Sickle cell disease. Brookfield, Conn: Twenty-First Century Books. Jones, P. (2008). Sickle cell disease. New York, NY: Chelsea House Publishers. Bloom, M. (1995). Understanding sickle cell disease. Jackson: University Press of Mississippi. Mankad, V. N., & Moore, R. B. (1992). Sickle cell disease: Pathophysiology, diagnosis, and management. Westport, Conn: Praeger. Rouse, C. M. (2009). Uncertain suffering: Racial health care disparities and sickle cell disease. Berkeley: University of California Press. Wailoo, K., & Pemberton, S. G....
10 Pages(2500 words)Research Paper
Coronary Artery Disease - Pathophysiology and Management
...? Coronary Artery Disease - Pathophysiology and Management Coronary heart disease is a serious disease which may lead to death if not well managed. This paper is going to focus on pathophysiology of the disease, its clinical manifestations, medical management and nursing considerations. Coronary Artery Disease - Pathophysiology and Management Introduction Coronary heart disease is also commonly known as coronary artery disease. It is a condition in which plague builds inside the coronary arteries (Cohen & Hasselbring, 2007). These arteries supply oxygenated blood to the heart muscles. Plague is a component of fat, cholesterol and other substances of the blood. Plague is slowly built up over several years forming a condition known... with CAD...
4 Pages(1000 words)Research Paper
Pathophysiology of Alzheimers Disease
...known as presenile dementia) was presented by Dr. Alzheimer in his speech in 1906, and subsequently published his findings in the year 1907.   Pathophysiology of Alzheimer’s Disease Anderson (2011) stated that alzheimer’s disease normally affects the three processes that maintain a healthy neuron. These are communication, metabolism, and repair. Any disruption of these processes may cause certain nerve cells in the brain to be ineffective, losing its connections with others neurons, and ultimately lead to cell death. As a result, memory starts to fail causing changes in the personality of a person, and difficulty in achieving day to day activities...
6 Pages(1500 words)Research Paper
Sickle Cell Disease
...? Sickle Cell Disease Sickle Cell Disease Sickle cell disease refers to a group of disorders among which sickle cell anaemia is the most common. It is an inherited disorder of blood and hence it is not contagious. Sickle cell disease is a gene-related disorder so it tends to run in families and those who do not carry the genotype of the disease, are at no risk of getting it ever in life. The diseased individuals inherit the genes from their affected parents and pass it on to their offspring. In sickle cell disease,...
5 Pages(1250 words)Research Paper
Children With Sickle Cell Disease
...Quality of life of children with sickle cell disease Caring for a child suffering from sickle cell disease needs extra demand on parents both psychologically and practically, which may influence their quality of life. This kind of disease is associated with communities with low socio-economic status. The main objective of the study was to evaluate the quality of life of caregivers of children suffering from sickle cell disease. A total of 700 healthy Dutch females and female caregivers of healthy children with the same ethnic background and socio-economic status were interviewed to compare their quality of life. The...
8 Pages(1000 words)Research Paper
Sickle cell disease
.... Therefore, the overall chance of their baby having cystic fibrosis is x x . 1/32, one in a 32. Both my friend and her fianc would need to undergo a genetic screening before starting a family, as there is 1 in 32 chance that their baby could have cystic fibrosis. Part 2: Sickle cell disease: Sickle cell disease is a genetic disorder caused by mutations of the -globin gene. There is a mutation of one single nucleotide from A to T, which results in a glutamic acid being replaced by valine at position 6 of the -globin gene. GAG, a codon, which codes for glutamic acid is changed to GUG resulting in replacement with valine (Pauling et al., 1949). In several forms of...
2 Pages(500 words)Essay
Pathophysiology of Disease
...Pathophysiology of Disease Order No. 269545 No. of pages: 8 1st 6530 Medical history and clinical information A 54-year old construction worker was referred to casualty. He had suffered a bout of haematemesis following lifting heavy beams. On examination, he was found to be 10 kg underweight, a little dehydrated and confused. The liver was firm and enlarged, and there was some pedal C on admission, and pulse was rapid and'oedema. His temperature was 42 irregular. There was also a history of alcohol abuse. The construction worker was rushed immediately to the emergency and a quick assessment was made. The person was in a semi- conscious condition, but taking into consideration all the above facts of the...
8 Pages(2000 words)Case Study
Sickle cell disease
...(tormenting, delayed erection). It additionally causes harm to the spleen, kidneys and liver. The harm to the spleen makes patients - particularly adolescent youngsters - effectively overpowered by bacterial diseases. An infant conceived with sickle cell infection inherits a gene for the issue from both folks. At the point when both folks/parents have the hereditary imperfection, theres a 25 percent risk that every youngster will be conceived with sickle cell infection (Monroe, 2008). Most individuals with SCD have a solitary abscond on both duplicates of chromosome 11 that makes them process imperfect hemoglobin atoms, which tie together and structure long, rodlike structures...
5 Pages(1250 words)Research Paper
Pathophysiology
...Pathophysiology: Describe the difference in presentation in patients with bipolar disorder versus generalized anxiety disorder. Use the DSM-5 criteria for your response Student name: Institution: Course name: Tutor name: Date due: Describe the difference in presentation in patients with bipolar disorder versus generalized anxiety disorder. Use the DSM-5 criteria for your response DSM-5 provides a standardized language which enables medical practitioners to communicate about mental disorders. The DSM-5 utilizes the word disorder to recognize the compound integration of cultural, psychological, biological and social elements associated with mental distress (Nussbaum & American Psychiatric Association, 2013). This paper will describe... engaged...
1 Pages(250 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Research Paper on topic Pathophysiology of Sickel Cell disease for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us