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Experimental Immunopharmacolgy - Essay Example

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Summary to essay on topic "Experimental Immunopharmacolgy"
Capsaicin (see Fig. 1) is an alkaloid of hot chilly. It has a unique effect on the nociceptive system because of its ability to excite sensory neurons by binding to its endoplasmatic receptors (Hui, Liu & Qin, 2002; Tominaga & Julius, 2000). The capsaicin receptor (VR1) were cloned recently and some other significant achievements were obtained in the recent studies (Tominaga & Julius, 2000) The methabolism of arachidonic acid could be mediated by capsaicin directly (Joe & Lokesh, 1997) furthermore some products of LOs-mediated oxidation can stimulate VR1 receptors (Hwang et al., 2000).
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Experimental Immunopharmacolgy
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Download file "Experimental Immunopharmacolgy" to see previous pages... Nevertheless the authors did not provide any pathophysiological substantiation of this effect. Probably, these changes were caused due to the antioxiodative features of capsaicin.
By the opinion of some authors the fact of capsaicin bidding to the intracellular side of the receptor is evidence of the presence of an endogenous intracellular activator.
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They consider that leukotrienes (products of LOs pathway of arachidocnic acid metabolism) could be such activator (ibid) (the hypothesis that certain products of LOs directly open capsaicin-activated channels. Thus the existence of the endogenous capsaicin-like substances was approved (Hwang et al., 2000; Huang et al., 2002).
...
Lipids. 32(11):1173-1180.
5. Tominaga & Julius (2000) Capsaicin receptor in the pain pathway. Jpn J Pharmacol. 83(1):20-23. ...Download file "Experimental Immunopharmacolgy" to see next pagesRead More
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