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Pharmacology Drug Profile - Essay Example

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1. Begin your drug profile by stating the chemical name, generic name, and the Australian trade names for your chosen drug. Chemical Name: Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-2-. (diethylamino)-2'6'-acetoxylidine. (Upfal 2006). Generic Name: Lidocaine Trade Names: lignocaine injection, Xylocaine, Xylocaine with adrenaline, Xylocard, Xyloproct suppositories, many ointments, gel, lotions and creams contain lignocaine (Upfal 2006)…
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Pharmacology Drug Profile
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Download file to see previous pages 2. a. List the approved indications for your drug. Approved indications of the Drug: Rectal: Pain and itching are relived temporarily from the area caused due to anorectal disorders. (Butler and Govindan 2010). Topical: it is mainly used as a local anesthetic for the cosmetic, laser and small surgeries and also for small burns, cuts and abrasions of skin. Patch: for the relief of pain associated with postherpetic neuralgia. It is used to relieve pain, to treat ventricular arrhythmias. (Butler and Govindan 2010). b. Determine whether your drug is approved for paramedic use in Australia, and if it is, list the approved paramedic indications for your drug. Paramedic Applications: This drug is approved for paramedic applications in Australia. Paramedic indications are 1. Suppression of ventricular arrhythmias 2. Prophylaxis against decreased ventricular tachycardia and ventricular fibrillation. 3. Frequent PVC’s 4. Pre-intubation for head trauma and for suspected Intra cranial hemorrhage. 5. Hypotension. (Stoller, Michota and Mandell 2009). 3. Add to your drug profile: 1. A list of conventional over-the-counter (OTC) medicines, complementary alternative medicines (CAMs) and prescription medicines that are known or suspected to undergo clinically relevant interactions with your profile drug IN HUMANS. Lidocaine Hydrochloride Xylocaine Zilactine –L AneCream Anestafoam Burn Jel Plus Burn Jel® L-M-X® 4 L-M-X® 5 LidaMantle Lidoderm LidoPatch LTAPremjact Regenecare RegenecareSolarcaine Topicaine Unburn (Kids health.org, 2012). 2. List the source(s) of information you have used and indicate the strength of the evidence (e.g. anecdotal report, clinical case, clinical trial, etc) for each of the interactions that you have identified. Rome, J.,2006. Mayo Clinic on Chronic Pain, Orient paperbacks. Kidshealth.org, 2012.kidshealth, Medications: what you should know, http://kidshealth.org/parent/medications/lidocaine_topical.html . 4. For your chosen drug: A. Describe the mechanism of action. Answer should: 1. Identify how the interaction of the drug with its molecular target(s) accounts for the major therapeutic effect (i.e. the effect you want the drug to cause in clinical practice; e.g. for paracetamol - pain relief) Lignocaine reversibly inhibits the conduction of action potentials in nerves and other excitable membranes. Lignocaine blocks the Voltage-gated Na + channels present in the neuronal membrane by acting as local anaesthetic. This type of blocking is very effective on all type of nerve fibres. The nerve fibres are first affected followed by the sensory and motor nerves. In the phase O of the cardiac potential, the antiarrhythmic effects of lignocaine occurs resulting in the blockage of the Na+ channels and leading to the reduced influx of the Sodium ions into the myocardial cell. The potential of the pacemaker is reduced by lignocaine resulting in the decreased heart beat rate. The duration of the action potential is reduced by increasing the effective refractory period and thus reducing the maximum rate of depolarization of the cardiac action potential. (Saeb-parsy etal, 1999). Lignocaine binds more readily with the inactivated Na+ channel. Lidocaine initially produces vasoconstriction but at later stages, it increases the vasodilation. This biphasic action increases the ...Download file to see next pagesRead More
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