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Role of Vitamin D in the Prevention of Cancers - Research Paper Example

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The author concludes that Vitamin D  may be of valuable importance by protecting us from some of the very deadly forms of malignancies like CRC, Breast CA, Pancreatic CA and Prostatic CA. But we should be keeping in mind that excessive exposure to sunlight can be a causative agent of skin cancers…
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Role of Vitamin D in the Prevention of Cancers
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Download file to see previous pages Calcitriol, the hormonally active form of this vitamin have been tested and proven in many of the animal models that it has got growth inhibitory as well as favorable effects on the differentiation of the tumor cells resulting in the slowing down of the tumor cells. So there are several trials which have used vitamin D as an anticancer agent and the main mechanisms of action of this vitamin include inhibition of cell proliferation, decreases inflammation in tumor cells, stimulate the process of apoptosis (the programmed cell death) and it also causes inhibition of the tumor angiogenesis (development of the blood vessels which provide nutrition to the tumor cells), oppose the invasion by the tumor cells and also inhibit metastasis (spread of tumor from one site to the other). [2]
The 1st observation which supported this belief that vitamin D prevents cancer came in the mid of the 20th century from the fact that people which were living in the areas with increase sun exposures suffered from a skin cancer usually Squamous Cell Carcinoma (S.C.C) which is not a fatal one usually due to its less likely to metastasize but these people showed decrease incidence of serious internal malignancies like breast, prostate or colorectal cancers which supported the fact that vitamin D has a protective effect by decreasing the incidence of malignancies.
The role of the vitamin D remains unclear until in the late 1980s when two epidemiologists named Garland brothers stated that adequate sunlight decreased the incidence of Colon Cancer. They also observed that women who were exposed to adequate sunlight have fifty percent less mortality from breast cancer than the women who have relatively less sun exposure.  ...Download file to see next pagesRead More
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