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Alternative solutions for Animal testing on medication - Essay Example

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The writer of the essay "Alternative solutions for Animal testing on medication" consider the animal testing to be to be a big problem in the United States. Researchers test pharmaceuticals in animals to determine toxicity, dosing, and efficacy before they start human clinical trials…
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Alternative solutions for Animal testing on medication
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Alternative solutions for Animal testing on medication

Download file to see previous pages... In Computer Simulation as a Tool for Studying Metabolism and Drug Design authors studied the Trypanosoma brucei (parasitic protist species that causes African trypanosomiasis or sleeping sickness) using computer simulation. There was a high-quality data available for them for most of the enzymes of glycolysis in the bloodstream form of Trypanosoma brucei, including all of those likely to be influential in controlling glycolytic flux in this organism (Cornish-Bowden, Eisenthal 165). Due to the availability of the body of kinetic information, it was possible to construct and validate a computer model of trypanosomal glycolysis. “T. bruce is the agent responsible for African sleeping sickness, a disease of major medical and economic importance, it becomes clear that it offers an ideal opportunity for exploring the potential value of computer simulation as a means of arriving at a better understanding of metabolism and hence a more rational approach to drug design” (Cornish-Bowden, Eisenthal 165). The results of these studies showed that “in ideal conditions, computer simulation is capable of providing information that is qualitatively different from what may appear obvious from inspection, is of potential practical value for the design of new pharmaceuticals, and is reliable” (Cornish-Bowden, Eisenthal). Results of these studies led researchers to the conclusion that computer simulation is to become an essential tool for achieving success in drug development and other biotechnological applications.
Computer simulation is as well widely used in drug design, modeling techniques for ...Download file to see next pagesRead More
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