Subject: Health sciences and medicine, Research Paper Topic: Final Paper: Role of anti-inflammatory agents in the prevention of type 2 diabetes in people with obesity Background Information Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by abnormalities in carbohydrates and fat metabolism (Scheen, 2003)…
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This chronic disease is characterized by excess glucose levels in the blood, as a result of abnormalities in its metabolism. This non-insulin-dependent diabetes mellitus may begin at childhood stage and become very severe. Insulin injection is a common mode of management since the pancreatic beta cells are not able to secrete enough insulin. Symptoms of the disease may include signs of polydipsia (taking large volumes of water) as a result of excessive thirst and polyuria (excessive urination). Even though it is ideally expected among adults, prevalence has been reported among younger populations because of the effect of obesity. The disease is majorly associated with age but is also associated with obesity and overweight among the younger population (Medline, 2012). Overweight and obesity according to World Health Organization (WHO) may be defined as excessive fat accumulation which may present health risk (WHO, 2012). The body mass index (BMI = person’s weight in kilograms divided by the square of his height in metres) is used to determine whether a person is obese or not. A BMI equal to 25 is overweight whereas more than 30 is considered obese. According to the World Health Organization (WHO), obesity has been increasing over the years in both developed and developing nations. In obesity, oxidative stress and inflammation are a common phenomenon which catapults insulin resistance and onset of T2DM (Badawi et al., 2010). Acute phase reactants such as TNF-?, IL-6 and C-reactive protein are evident of inflammation and various studies have demonstrated their presence in obese subjects (Dandona et al., 2004; Pradhan et al., 2001). With the ever increasing incidence of T2DM worldwide, it is crucial to develop or design preventative measures or strategies especially to certain population at high risk of acquiring the disease, people living with obesity (Emmanuela et al., 2012). Calculated measures aimed at reducing the oxidative stress and consequently the inflammation will be crucial in preventing the development of type 2 diabetes mellitus in the obese individuals group. Various studies have linked T2DM and obesity via inflammation, it is therefore imperative to cut the link through administration of anti-inflammatory agents to the obese individuals. This forms the basis of the research question in this study. Research Question What is the role of anti-inflammatory agents in prevention of type 2 diabetes (T2DM) in people with obesity?’ The incidence rates of T2DM have been on the increase worldwide as reported by Emmanuela et al (2012). This increase has seen some proportion of the population being at a high risk of developing the disease. This group is comprised of obese individuals who are prone to developing T2DM. Therefore, the research question explores ways that may be used to tame the spread of the condition to this group. Inflammation in the obese subgroup of the population provides the link between the obesity and development of T2DM. This is the route that the research question seeks to address and form the basis of this research undertaking. Hence the research question undertakes to fill the gap of knowledge as to whether anti-inflammatory agents play any role in prevention of T2DM especially in the obese subset of the general population
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