Nobody downloaded yet

Evaluation of L-Proline as a Catalyst for an Asymmetric Aldol Reaction - Lab Report Example

Comments (0) Cite this document
The experimentation also aimed at quantification of the enantiomeric enrichment of the product by use of the Mosher ester approach.
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER96% of users find it useful
Evaluation of L-Proline as a Catalyst for an Asymmetric Aldol Reaction
Read TextPreview

Extract of sample
"Evaluation of L-Proline as a Catalyst for an Asymmetric Aldol Reaction"

Download file to see previous pages The product was then extracted with 10mL of ethyl acetate.
Drying was done over MgSO4 . the separation of the drying agent was done via gravity filtration, whereas that of the solvent was done through rotary evaporation. The product was further taken through purification steps, which involved the use of flash chromatography using 50% petroleum ether/ 50% ethyl acetate as the eluting solvent. The fractions were then combined and the solvent eliminated via evaporation method. The massed of the obtained products were then recorded, and verification obtained.
To conduct the Mosher analysis, 15mg of the Aldol product were dissolved in 0.9mL of anhydrous CH2Cl2 in a flame dried vial. 1.5mg of 4-dimethylaminopyridine (DMAO) followed by 15ᴫL pyridine and MTPA-Cl were added. The solution was then sealed and allowed to react under nitrogen. After the reaction was complete, the isolation process followed. The crude reacrion was washed with 0.1 N HCL (0.5 mL), saturated bicarbonate solution (0.5 mL) and brine (0.5mL). The ratio of diastereomers by H-NMR was determined and enantiomeric excess of the Aldol reaction computed.
From the analysis of the results obtained from the experimentation, it was clear that L-proline functions as a catalyst in a reaction involving Aldol. The product was further quantified by use of the Mosher ester approach. Consequently, a conclusion was drawn that L-proline functions as a catalyst in Aldol reactions.
One of the powerful methods through which carbon-carbon bonds can be formed is through nucleophilic addition of an enolate to a carbonyl group. An example of the scenarios in which this principle has been applied is in the de novo generation of carbohydrates which results from the development of aldolase enzymes, which catalyze biological Aldol reactions. The ability of aldolases to produce enantiomeric product exclusively is a notable feature, difficult for the modern synthesis ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Evaluation of L-Proline as a Catalyst for an Asymmetric Aldol Reaction Lab Report”, n.d.)
Retrieved from
(Evaluation of L-Proline As a Catalyst for an Asymmetric Aldol Reaction Lab Report)
“Evaluation of L-Proline As a Catalyst for an Asymmetric Aldol Reaction Lab Report”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Reaction Outcome Evaluation
However, how effective are these programs? Often times, trainings and conferences are conducted to ensure the competitiveness of employees in the professional environment. With the limited amount of time that these
2 Pages(500 words)Assignment
Reaction Essay
he article “‘Doin’ the hustle’ Constructing the ethnographer in the American ghetto”, Sudhir Venkatesh (2002) narrates about his completion of an ethnographic study of a poor public housing development in Chicago which provided him the empirical frame for an
6 Pages(1500 words)Lab Report
Frenken/Leonard Reaction Essay
Prostitution does not only occur among the young male and female but also among the transsexual males, lesbians and bisexuals who belong to the low-income families. (Goldman, 2007) As part of the country’s effort on combating prostitutions, police
4 Pages(1000 words)Lab Report
Studies on Photosynthesis Using the Hill Reaction Report
Photosynthesis is represented by the following reaction: The complex process of photosynthesis is classified in to two stages based on
2 Pages(500 words)Lab Report
Evaluation of Three Different Types of Spectroscopy
atoms and amount of light absorbed, therefore, we can determine the concentration of the sample by measuring the amount of light absorbed (Karabegov, 2011). Samples have to be heated to extremely high temperatures in other to atomise them. The sample goes through a nebulizer
2 Pages(500 words)Lab Report
Diels-Alder Reaction
The prevailing products of the reaction will be stored in the laboratory drawer while obtaining characterization data. Characterization data entail melting point, carbon
2 Pages(500 words)Lab Report
Developing probes of cathepsin L
The peptides are mostly associated with the degradation of proteins especially because of their association with lysosomes. The present study involved the synthesis of cathepsin molecule. The experiment aimed to obtain Z-cbz-Phe-Arg(OH) hence used
6 Pages(1500 words)Lab Report
Rate of product formation in an enzyme - catalyzed reaction
The optimum pH range was found to be 5-6 and the given enzyme does not work at all in the pH 3. Enzymes are protein molecules present in all the living cells. They act as biological catalyst for speeding up the reactions by lowering the energy barrier. Enzymes are made
5 Pages(1250 words)Lab Report
Having Breakfast Affects Reaction Time
Two groups were tested for reaction time in a choice reaction task. The first group had breakfast prior to testing while the second
7 Pages(1750 words)Lab Report
Synthesis of Dibenzalacetone by Aldol Condensation of Benzaldehyde and Acetone
Aldol condensation proceeds via an addition reaction between an aldehyde and a ketone, resulting in the formation of an aldol. The aldol product undergoes dehydration to give an enone product. In the present experiment, benzaldehyde, an aldehyde, reacts with acetone, a ketone, to give dibenzalacetone.
7 Pages(1750 words)Lab Report
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Lab Report on topic Evaluation of L-Proline as a Catalyst for an Asymmetric Aldol Reaction for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us