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Tetracycline Antibiotics - Essay Example

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Tetracycline antibiotics were obtained after the systematic screening of soil samples from all parts of the world for microorganisms capable of producing antibiotic substances. The paper "Tetracycline Antibiotics" discusses the structure and mode of action of tetracycline antibiotics…
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Tetracycline Antibiotics
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Download file to see previous pages Chlortetracycline was the first compound from this class which was successfully used to treat diseases of bacterial origin. They are one of the most widely used classes of antibiotics today and several thousand of varieties have been synthesized till date (Aleksandrov & Simonson, 2008). Chlortetracycline and Oxytetracycline are obtained from Streptomyces Aure-Facie ns and Streptomyces rumors respectively (Goodman & Gilman, 2001). Other semi synthetic tetracyclines are Tetracycline, Methacycline, Doxycycline, and Minocycline.All tetracyclines are congeners of polycyclic naphthalene carboxamide and chemical substituents and their position determine the type of tetracycline (Goodman & Gilman, 2001). Chemically Tetracyclines are polyketides and comprise of a naphthacene ring structure (Thiele-Bruhn, 2003). They are amphoteric compounds and are relatively stable in acids. They are sparingly water soluble while the solubility of corresponding hydrochlorides is much higher. They strongly absorb light and are therefore subject to photodegradation.Tetracyclines are basically bactericidal in action and do so by inhibiting bacterial protein synthesis (Goodman & Gilman, 2001). They do so by binding to the 30 S bacterial ribosome, thereby preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. The active transport system found in the bacterial cells enhances the passage of the tetracyclines into them by the process of passive diffusion through the hydrophilic channels. ...Download file to see next pagesRead More
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