Nobody downloaded yet

Naloxone's Drug Profile - Essay Example

Comments (0) Cite this document
Name: Instructor: Course: Date: Naloxone’s Drug Profile Section 1: Part One Naloxone helps in reversing opioid effects like hypotension, depression, and respiratory sedation. It can also reverse constipation associated with opioids. When administered orally, Naloxone has a bioavailability ranging from 1.9 per cent to 2.2 per cent for the 20 milligram and 120 milligram oral doses…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER94.6% of users find it useful
Naloxones Drug Profile
Read TextPreview

Extract of sample "Naloxone's Drug Profile"

Download file to see previous pages Many greater doses are needed when using oral administration for any pharmacologic effect. Naloxone is absorbed in the liver, mainly through glucuronide conjugation, and eventually excreted from the body system in urine. Part Three Because of the penetrating biotransformation in the liver, Naloxone is ineffectual when taken orally, and because of this, it is dispensed exclusively for parenteral use (Robertson et al 512-5). Section 2 Part One Naloxone is available in both parenteral and oral formulations. In Australia, Naloxone comes as a sterilized solution for intramuscular, intravenous, and subcutaneous administration in three strengths (1milligram, 0.4milligram, and 0.02milligram) for every milliliter in the sterilized solution. Every milliliter of the one-milligram strength has 8.35 milligrams of NaCl. In Australia, Naloxone may be referred to by different brand names such as TARGIN or buprenorphine. They are offered in four strengths, which are 5/2.5 milligrams, 10/5 milligrams, 20/10milligrams 40/20 milligrams, and TARGIN tablets that come in boxes that have blister packs of 20 to 28 tablets. Packs of 20 tablets are only available until current stocks deplete (Kelly and Koutsogiannis 375) Part Two A Naloxone hydrochloride is injected either intravenously, intramuscularly, subcutaneously, or orally. Intravenous administration has proved to work faster than all the other forms of administration, hence its recommendation for use in emergency cases. As such, it is preferred in emergency circumstances. In intravenous infusion Naloxone, hydrochloride may be diluted in dextrose injection 5 per cent or sodium chloride injection 0.9 per cent (O’Malley-Dafner and Davies 212). Products from parenteral drugs ought to be examined visually for any complication such as discoloration prior to administration. Naloxone hydrochloride dose should not be mixed with any alkaline solution, preparations containing bisulfite, high-molecular-weight anions, metabisulfite, and long-chain. There should be no addition of chemical agents or drugs to this solution unless one knows its outcome on the solution’s chemical and physical and stability. Section 3 Part One After a parenteral administration, Naloxone quickly disperses in the body system, freely crossing the placenta. The binding of plasma protein follows, but has been reported to be rather weak. Although the principal binding component is plasma albumin, plasma constituents also undergo naloxone binding. Part Two The drug’s distribution volume in plasma, which is 3litres per kilogram (this is more or less equal to 210 litres for a 70kilogram person versus five to six liters of blood in the same person, which would seem rather large). However, to get transported, the drug is usually bound to plasma proteins for transport (Martin 415). Naloxone is 61.5 per cent in fetal plasma and 54 per cent protein bound in adults. Part Three The usual adult dose is 0.4 to 2 milligram per dose of intravenous, and intramuscular, or subcutaneously administration and it may sometimes be repeated at two or three-minute intervals. Therapy is done if there is no response after accumulative dose of 10 milligrams. Naloxone is given intracisternally in loading doses. 0.1 milligram/kg/dose is given to children and infants who are less than or equal to five years or less than or equa ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Naloxone's Drug Profile Essay Example | Topics and Well Written Essays - 1750 words”, n.d.)
Naloxone's Drug Profile Essay Example | Topics and Well Written Essays - 1750 words. Retrieved from
(Naloxone'S Drug Profile Essay Example | Topics and Well Written Essays - 1750 Words)
Naloxone'S Drug Profile Essay Example | Topics and Well Written Essays - 1750 Words.
“Naloxone'S Drug Profile Essay Example | Topics and Well Written Essays - 1750 Words”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Naloxone's Drug Profile

Pharmacology Drug Profile

... Begin your drug profile by stating the chemical generic and the Australian trade s for your chosen drug. Chemical Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-2-. (diethylamino)-2'6'-acetoxylidine. (Upfal 2006). Generic Name: Lidocaine Trade Names: lignocaine injection, Xylocaine, Xylocaine with adrenaline, Xylocard, Xyloproct suppositories, many ointments, gel, lotions and creams contain lignocaine (Upfal 2006). Other names: Anestacon, Esracaine, Gravocain, Leostesin, Lidoderm, Maricaine, Cappicaine. (Upfal 2006). Molecular weight : 234.33728. (Upfal 2006). Molecular formula: C14H22N2O. It is a generic and prescribed drug under Schedule S.3, 4 in Australia. Figure1: Chemical structure of Lignocaine. 2. a. List the approved... ....
11 Pages(2750 words)Essay

Pharmacology (Drug Profile Midazolam)

...the Michaelis-Menten Kinetics. The inhibition of Midozolam and the enzyme was because of the (+)-N-3-benzylnirvanol and S-mephenytoin. The inhibitory effect was very good for CYP3A4/5 enzyme and was not the same for CYP2C19 enzyme. (Emoto and Iwaski 2007) 8. The Midazolam is found to interact with analgesics, antiasthma medications, antimicrobials, cardiovascular drugs, CNS drugs, gastrointestinal tract drugs, local anaesthetics and muscle relaxants. Analgesics: Aspirin and diclofenac when combined with Midozolam are found to increase the sedatory effect. Antiasthma medications: Aminophylline reduces the effectiveness of Midozolam. Antimicrobials: ciprofloxacin decreases...
11 Pages(2750 words)Essay

Drug profile

.... The resulting Salbutamol sulphate (in red) is then released unto the urine. However, the rate of sulfation of bronchodilating R-Salbutamol is greater than the potentially toxic S-enantiomer. The former thus has a lower bioavailability than the latter (Walle et al., 1996). Sixty percent of the excreted drug is the metabolite (Albuterol, 2011). Sources of Variability in Salbutamol Metabolism The plasma levels of Salbutamol were found to be greater among asthmatics than healthy adults. This had been attributed to the higher intestinal permeability among asthmatics, or the lower amounts of inorganic sulphur needed for the conjugate reaction during the drug’s metabolism (Sjosward et al.,...
8 Pages(2000 words)Essay

Drug profile of pharmacology ( Naloxone )

...? Naloxone Introduction: Opium, derived from the poppy seeds was used as early as the 3rd century. In the 19th century, morphine, a derivative of opium, was used as a narcotic agent. Opioids bind to the opioid receptors that are present in the central nervous system and peripheral nervous system and produce their therapeutic effects. Opioids are the morphine like synthetic drugs that produce the same effect as that of morphine for pain relief, respiratory depression, constipation and sedation. Opioids antagonists block the (µ , ? and ?) opioid receptors. (Flomenbaum et al. 2006). Opioid antagonists, when administered before treatment, block the opioid agonists by preventing their action. They also reverse...
8 Pages(2000 words)Essay


...?Profile Instruction: Task: Aysha Janahi is an interesting studying Media Communication at his second year. He is a particularly interesting target for this profile exercise for many reasons that include his gentility in tackling pressing matters. Additionally, the fact that Aysha came from conservative Bahrain and sought schooling in the liberal American education is an illuminating indicator of a flexible young person (Stein & Paterno 2001, p. 56). In other words, the student actively displays the character trait of a young man willing to experiment with culture, customs and traditions of foreigners in order to discover meaningful integration. Therefore, his choice to make appearance in this...
3 Pages(750 words)Essay

Drug Profile Paper

...? Abused Substances There are several substances which are abused in different capacities by people in attempt to achieve various luxuries. Most of these substances are addictive and once you start using them, it may need a lot of stress to overcome. Continuous abuse of these substances always leads to negative consequences which can even lead to loss of lives and reputation in social set up. These abused substances fall under different categories due to the nature of their origin and how they affect humans when abused and are discussed below. Stimulants These are drugs that make a person feel more alert and they occur naturally in many plants. Example is caffeine found in tea, coffee and chocolate which are readily...
6 Pages(1500 words)Essay

Drug Profile Chart

...of Phoenix Material Drug Profile Chart Address the four categories of depressants, stimulants, narcotics, and hallucinogens. For each category, identify specific substances within it, street names, methods of administration, addiction potential, paraphernalia, what effects you might observe in the workplace with a user of this substance, withdrawal symptoms, and treatment possibilities (be sure to list both homeopathic and allopathic where applicable). Include a reference page citing your resources, and include sources other than websites. DRUG STREET NAME(S) METHODS OF ADMINISTRATION (include user paraphernalia) POSSIBLE EFFECTS (include physiological effects,...
2 Pages(500 words)Essay

Choose drug(s) classified as narcotic analgesics

...of many criminals is Purdue Pharmas OxyContin, a sustained-release oxycodone product. Specifically formulated to meet the needs of patients with chronic, intractable pain, OxyContin is being crushed by abusers to make the full dose immediately available when they inhale, swallow, or inject it” (par. 3). As emphasized by the USDHHS, “Oxycodone can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor” (par. 6). Just like any other narcotic analgesics, the tendency for drug abuse is strong and therefore needed precautions are to be observed to prevent addiction to the drug. However, the drug has been proven to...
2 Pages(500 words)Research Paper

Drug Profile activities for Module 2

...Drug Profile Activities for Module 2 Drug Profile Activities for Module 2 Comparing Levosalbutamol and Racemic Salbutamol in the treatment of acute exacerbation asthma (Punj, A., Prakash A., and Bhasin A. 2009. Levosalbutamol Vs Racemic Salbutamol in Treatment of Acute Exacerbation of Asthma, Randomized Double blind clinical study. Indian Journal for Pediatrics. Vol. 76(11), pp.1131-1135.) Type of Study: randomized double blind clinical study. Comparable agent: racemic salbutamol. Sample size: 60 children suffering from exacerbation asthma. Measures of effectiveness: levosalbutamol appears to be more effectual. Than racemic salbutamol in terms of improving PEFR, SPO2 and asthma score. In the racemic salbutamol, deleterious effect... score,...
2 Pages(500 words)Research Paper


...Personality Profile: Gary Desir Gary Desir is not your typical college He may sport as a typical but there is more than him that meets the eye. He may frequent the club as any young man his age or immersed in movies and music as anybody would do, but that is not all him. He may look like a social butterfly but he knows his priority – to get an International Business Degree from Johnson and Wales University. H ecould play tought being a football player, but he is more than the sport. He does all this and having fun because he wants to make the most out of life but he does not lose sight of his goal. As he said “eyes on the price” meaning not to forget the degree even if he indulges with what life can offer. He may look like...
1 Pages(250 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Naloxone's Drug Profile for FREE!

Contact Us