Nobody downloaded yet

Drug profile of pharmacology ( Naloxone ) - Essay Example

Comments (0) Cite this document
Summary
Naloxone 1. Introduction: Opium, derived from the poppy seeds was used as early as the 3rd century. In the 19th century, morphine, a derivative of opium, was used as a narcotic agent. Opioids bind to the opioid receptors that are present in the central nervous system and peripheral nervous system and produce their therapeutic effects…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER94.6% of users find it useful
Drug profile of pharmacology ( Naloxone )
Read TextPreview

Extract of sample "Drug profile of pharmacology ( Naloxone )"

Download file to see previous pages They also reverse the effect of the exogenous and endogenous opioid receptors by creating perceptible of opioid withdrawal in the opioid dependent patients. The common Opioid antagonists are naloxone and nalmefene and naltrexone are competitive antagonists for the opioid receptors. Naloxone is used primarily for the patients suffering from respiratory depression. 2. Naloxone – An introduction: Chemical name: “(-)-17-Allyl-4, 5a-epoxy-3, 14-dihydroxymorphinan-6-one.” (Sinatra, Jahr and Watkins-Pitchford, 2010). Generic Name: Naloxone Trade names: “Naloxone hydrochloride Injection (DBL or CSL brands), Naloxone Min-I-Jet Suboxone (in combination with Buprenorphine), Targin (in combination with oxycodone).” (Sinatra, Jahr and Watkins-Pitchford, 2010). Other Names: “L-Naloxone , N- Allylnoroxymorphone, Nalossone, Naloxona, Naloxone HCl, Naloxonum.” (Sinatra, Jahr and Watkins-Pitchford, 2010). Similar Ligands of Naloxone: Nalmefene, naltrexone, (+) – Naloxone, Naloxonazine, nalbuphine, naltriben and naltrindole, naloxone benzoylhydrazone, TRK820, beta – FNA, etorphine, diprenorphine, buprenorphine, nor-binalto and BNTX .(Sinatra, Jahr and Watkins-Pitchford, 2010). ...
It is mainly used for managing opiate dependence syndrome and respiratory depressions caused by overdose of Opioids. The paramedic indications are: 1. Antinarcotic agents. 2. Narcotic antagonists. 3. Depressants. 4. Opiate Antagonists. 5. Reverse sedations caused by Opioids. 6. Respiratory depressants in neonatal care. 3. Mechanism of Action: Naloxone reverses the effect of the opioid overdose. Naloxone competitively binds to the opioid receptors and replaces the opioid molecules. By doing so, it reverses the effect of the agonists such as heroin. Naloxone is competitive antagonists at the mu, kappa and delta receptors. They have 10 fold greater affinity for the mu receptors. (Harvey and Champe 2008). Naloxone does not have any effect on the normal individuals but they precipitate the withdrawal symptoms at the abuse users. Animal studies have suggested that Naloxone inhibits GABA release and stimulates the cholinergic activity. Similarly they do not reverse the effects of ethanol. Naloxone first increases the local blood flow. (Harvey and Champe 2008). Then the drug crosses the cellular membrane and increases the cellular metabolism. Finally it aids in cell repair. Fig 2: competition of Naloxone with the opioid agonists. (Harvey and Champe 2008). Pharmacology: Naloxone is a pure competitive antagonist for the mu receptors. Mu receptors are responsible for miosis, euphoria, feeding, sedation and respiratory depression. Naloxone binds to the competitive receptors such that their antagonists or partial antagonists or mixed agonist- antagonist binding without any independent action. (Flomenbaum et al. 2006). The pharmacokinetics of naloxone differs from the other antagonists. Some studies have also found that extreme low doses of naloxone (0.25 micrograms per ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Drug profile of pharmacology ( Naloxone ) Essay”, n.d.)
Drug profile of pharmacology ( Naloxone ) Essay. Retrieved from https://studentshare.org/chemistry/1455997-drug-profile-of-pharmacology-naloxone-
(Drug Profile of Pharmacology ( Naloxone ) Essay)
Drug Profile of Pharmacology ( Naloxone ) Essay. https://studentshare.org/chemistry/1455997-drug-profile-of-pharmacology-naloxone-.
“Drug Profile of Pharmacology ( Naloxone ) Essay”, n.d. https://studentshare.org/chemistry/1455997-drug-profile-of-pharmacology-naloxone-.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Drug profile of pharmacology ( Naloxone )

Pharmacology

...products for manufacture of drugs. Tulp and Bohlin (2004, p.450) note that given the importance of plants as a source of drug, there have been research on ethno-pharmacology and toxicology which has helped to produce drugs from plants. Reliance on natural products as a source of drugs was overtaken by synthetic products because pure products could be obtained from synthetic compounds as argued by Newman (2003, p.1026). Moreover, it is easier to do structural modification to synthetic compounds which leads to the production of potentially safer and more active drugs. Furthermore, throughout human culture development, use of natural...
13 Pages(3250 words)Essay

Pharmacology Drug Profile

... Begin your drug profile by stating the chemical generic and the Australian trade s for your chosen drug. Chemical Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-2-. (diethylamino)-2'6'-acetoxylidine. (Upfal 2006). Generic Name: Lidocaine Trade Names: lignocaine injection, Xylocaine, Xylocaine with adrenaline, Xylocard, Xyloproct suppositories, many ointments, gel, lotions and creams contain lignocaine (Upfal 2006). Other names: Anestacon, Esracaine, Gravocain, Leostesin, Lidoderm, Maricaine, Cappicaine. (Upfal 2006). Molecular weight : 234.33728. (Upfal 2006). Molecular formula: C14H22N2O. It is a generic and prescribed drug under Schedule S.3, 4 in Australia. Figure1: Chemical structure of Lignocaine. 2. a. List the approved... ....
11 Pages(2750 words)Essay

Pharmacology (Drug Profile Midazolam)

...? Midazolam Midazolam is an imidazobenzodiazepine soluble in water at acid formulation and also highly lipid soluble. The main advantage of Midazolamis the rapid onset and the high metabolic clearance of the compound. The other pharmacological advantages are, they cause no irritation, has anxiolytic, amnestic properties and the induction is non-painful and rapid. (Reves et al. 1985). 1. The chemical name of the drug is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine. 2. The approved indications of the drug a) Intravenous administration along with an opoid is done for sedation and for the induction of the general anaesthesia and for ventilation of the sedated...
11 Pages(2750 words)Essay

Drug profile

...of cardioselective beta-receptor blocker may also be considered, although it may cause bronchospasm (Albuterol, 2011). References Albuterol. (2011). Micromedex (updated Oct 20th, 2011). [Online]. Available from http://www.drugs.com/albuterol.html [Accessed November 1, 2011]. AlbulterolSulfate. (1999). Drug Profile for AlbuterolSulfate. Department of Health and Human Services. [Online.] Available from http://www.azdhs.gov/diro/admin_rules/guidancedocs/gd-028-phs-ems.pdf [Accessed October 31, 2011] ______. (2010). ‘GenRx Salbutamol Inhalation Ampoule’, Product Information – Australia (Jan.15). [Online]. Available from http://www.medicines.org.au/files/gxpsalbu.pdf [Accessed October 29, 2011] Burton, M.E....
8 Pages(2000 words)Essay

Naloxone's Drug Profile

...Naloxone’s Drug Profile Section Part One Naloxone helps in reversing opioid effects like hypotension, depression,and respiratory sedation. It can also reverse constipation associated with opioids. When administered orally, Naloxone has a bioavailability ranging from 1.9 per cent to 2.2 per cent for the 20 milligram and 120 milligram oral doses. The bioavailability is low due the significant first-pass hepatic metabolism (O’Malley-Dafner 7; Davies 722-3). Part Two Orally administered, Naloxone undergoes a wide metabolism in normal subjects. It is minimally absorbed when given orally as it is quickly destroyed in the GI tract. Many greater...
7 Pages(1750 words)Essay

Pharmacology

..., ring hydroxylation and conjugation (Bennett, 1992). The oxidative N-dealkylation process is the major pathway in biotransformation of the drug in the liver. The oxidative N-dealkylation pathway produces glycinexylidide and monoethylglycinexylidide metabolites that have less potent pharmacologic effects than lignocaine (Kwan, 2001). In addition, these metabolites are less toxic than the primary drug. Section 2. Drug formulation and administration routes List all the formulations and doses available in Australia In Australia, Lignocaine is available as a lignocaine injection, Xylocaine, Xylocaine with adrenaline, Xylocard, Xyloproct suppositories. In addition, it is also...
9 Pages(2250 words)Essay

Drug Profile Paper

...://www.youthbeyondblue.com/factsheets-and-info/fact-sheet-10-cannabis-and-your-mental-health/ Dingfelder, F.D. (2011). The Danger of Stimulants. Monitor Staff. Vol 42, No. 9 Fantegrossi, W.E, Murnane, K.S, and Reissig, C.J. (2008).The behavioral pharmacology of hallucinogens. Biochem Pharmacol 75(1):17-33. Mayo Clinic staff. (2013). Drug addiction: Treatment of drugs. Mayoclinic. Retrieved from http://www.mayoclinic.com/health/drug-addiction/DS00183/DSECTION=treatments-and-drugs... ? Abused Substances There are several substances which are abused in different capacities by people in attempt to achieve various luxuries. Most of these substances are addictive and once you start using them, it may need a lot of stress to overcome. Continuous...
6 Pages(1500 words)Essay

Pharmacology

...? Pharmacology Administration of medication in hospitals requires a lot more than giving patients their medication. According to the AFH rules, caregivers must always be aware of every patient’s medication administration schedule, why the patient is being given the medication, its effects and any side effects that could arise. Medication administration process includes getting medical orders, writing medical orders on the (MAR) medical administration record, comparing the medical orders with the ones on the MAR to ensure they are correct, delivering and administering the medication to the patients, monitoring the patient’s progress and recording, storing and getting rid of expired, unused and contaminated medication....
4 Pages(1000 words)Assignment

Drug Profile Chart

...of Phoenix Material Drug Profile Chart Address the four categories of depressants, stimulants, narcotics, and hallucinogens. For each category, identify specific substances within it, street names, methods of administration, addiction potential, paraphernalia, what effects you might observe in the workplace with a user of this substance, withdrawal symptoms, and treatment possibilities (be sure to list both homeopathic and allopathic where applicable). Include a reference page citing your resources, and include sources other than websites. DRUG STREET NAME(S) METHODS OF ADMINISTRATION (include user paraphernalia) POSSIBLE EFFECTS (include physiological effects, addiction potential, and...
2 Pages(500 words)Essay

The Drug Diazepam in Pharmacology

...The Drug Diazepam in Pharmacology Section 1: Introductory Concepts 1. Drug Profile Chemical name: 7-chloro-1-methyl- 5-phenyl- 1, 3-dihydro-2H- 1,4-benzodiazepin-2-one Generic Name: Diazepam Australian Trade Names: Ranzepam, Antenex, Valium, Valpam, Diazepam, Diazepam Elixir, Diazepam Rectal Solution. 2. A. List the approved indications for your drug. Diazepam is used for the management of anxiety disorders. Diazepam can also be used for acute alcohol withdrawal, the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Diazepam can also be used to treat trauma (injury, inflammation) to muscles, bones and...
17 Pages(4250 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Drug profile of pharmacology ( Naloxone ) for FREE!

Contact Us