Nobody downloaded yet

Drug profile - Essay Example

Comments (0) Cite this document
Summary
SALBUTAMOL SULFATE Chemical Name: a1-[(tert-butylamino)methyl] -4-hydroxy-m-xylene-a, a'-diolsulfate (2:1)(salt) Generic Name: Salbutamol Sulfate Trade Names: As listed by Australia’s Department of Health and Ageing, Salbutamol sulfate is available in the market as Ventolinrotacaps or Ventolin syrup…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER93.2% of users find it useful
Drug profile
Read TextPreview

Extract of sample
"Drug profile"

Download file to see previous pages Indications: - bronchial asthma (RACGP, 2006; Lullman et al., 2000), - bronchitis (RACGP, 2006) - exercise-related dyspnea (RACGP, 2006) - other breathing problems (RACGP, 2006). - pre-term labour (Morgan et al., 1987). According to the Medical Reference Manual by Adult Retrieval Victoria (2011), Salbutamol (5-10 mg or 8 puffs 10-15 minutely) is one of the standard therapies for refractory asthma. Continuous nebulised Salbutamol is also used for maximum pre-intubation therapy. As well, the Queensland Ambulance Service (2011) lists approved emergency indications as bronchospasm and suspected hyperkalaemia with QRS widening and/or AV dissociation (Medical Director’s Office 2011 p. 69) for adult and paediatric administration (p. 70). Contraindications against paramedic use of salbutamol have been reported to include potential synergism with other sympathomimietics. It should also be used with caution in patients with diabetes, hyperthyroidism, and cerebrovascular disease (Albuterol 1999, p. 1). List of drug-drug interactions with Salbutamol (Albuterol 2011) Medicine name Strength Atomotexine – may cause CVS effects such as tachycardia and hypertension case reports Digitalis – hypokalemia induced by salbutamol may cause cardiac glycoside toxicity Mechanism already elucidated Diuretics – hypokalemia Steroids – hyperglycemia or hypokalemia Sympathomimetics – additive effects Theophylline – additive effects Xanthine derivatives –hypokalemia Bendrofluazide – augments hypokalemia, cardiac effects, arrhythmia Signal Transduction Mechanisms for ?2 Receptors Figure 1.The messenger system starting with the activation of receptor, which stimulates the G-protein to dissociate into its subunits. The ?-subunit then activates the enzyme converting ATP to cAMP. Figure from Guyton, A. C. and Hall, J. E. 2006. Textbook of Medical Physiology. Philadelphia: Elsevier. Salbutamol is an agonist of the beta 2 adrenergic receptors found on the smooth muscle lining airways of the lungs (Lullman, 2000). The intracellular components of the receptor are associated with G protein. In turn, G protein has three sub units (alpha sub unit, plus tightly associated beta, and gamma sub units). Upon binding of salbutamol to ?2 receptor, the latter activates the G protein, causing GDP (guanosine 5'-diphosphate) associated with the G protein to be phosphorylated to GTP (guanosine 5'- triphosphate), which initiates detachment of alpha subunit. The alpha subunit binds with adenylyl cyclase, which catalyses the conversion of ATP to cAMP (adenosine 5'-triphosphate to adenosine 3',5'-monophosphate) (Guyton and Hall, 2006). cAMP then inhibits myosin light chain kinase which is responsible for the contraction and hence constriction of bronchial smooth muscle (Klabunde, 2008). The inhibition of myosin light chain kinase promotes the physical relaxation and hence dilation of the smooth muscle lining of the affected airways which improves the potential for improved respiration which is key to addressing several pulmonary disorders Evidence of Clinical Effectiveness Despite being the most used ?2-agonist, research on the clinical effectiveness of Salbutamol had contradicting results. In a randomized control trial on salbutamol against preterm labor, 100 women, ages 17-32 years old and between 20-37 weeks pregnant, were recruited. ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Drug profile Essay Example | Topics and Well Written Essays - 2000 words”, n.d.)
Retrieved from https://studentshare.org/chemistry/1440686-drug-profile
(Drug Profile Essay Example | Topics and Well Written Essays - 2000 Words)
https://studentshare.org/chemistry/1440686-drug-profile.
“Drug Profile Essay Example | Topics and Well Written Essays - 2000 Words”, n.d. https://studentshare.org/chemistry/1440686-drug-profile.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
Pharmacology Drug Profile
... Begin your drug profile by stating the chemical generic and the Australian trade s for your chosen drug. Chemical Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-2-. (diethylamino)-2'6'-acetoxylidine. (Upfal 2006). Generic Name: Lidocaine Trade Names: lignocaine injection, Xylocaine, Xylocaine with adrenaline, Xylocard, Xyloproct suppositories, many ointments, gel, lotions and creams contain lignocaine (Upfal 2006). Other names: Anestacon, Esracaine, Gravocain, Leostesin, Lidoderm, Maricaine, Cappicaine. (Upfal 2006). Molecular weight : 234.33728. (Upfal 2006). Molecular formula: C14H22N2O. It is a generic and prescribed drug under Schedule S.3, 4 in Australia. Figure1: Chemical structure of Lignocaine. 2. a. List the approved... ....
11 Pages(2750 words)Essay
Pharmacology (Drug Profile Midazolam)
...? Midazolam Midazolam is an imidazobenzodiazepine soluble in water at acid formulation and also highly lipid soluble. The main advantage of Midazolamis the rapid onset and the high metabolic clearance of the compound. The other pharmacological advantages are, they cause no irritation, has anxiolytic, amnestic properties and the induction is non-painful and rapid. (Reves et al. 1985). 1. The chemical name of the drug is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine. 2. The approved indications of the drug a) Intravenous administration along with an opoid is done for sedation and for the induction of the general anaesthesia and for ventilation of the sedated patients. b) Oral...
11 Pages(2750 words)Essay
Drug profile of pharmacology ( Naloxone )
...? Naloxone Introduction: Opium, derived from the poppy seeds was used as early as the 3rd century. In the 19th century, morphine, a derivative of opium, was used as a narcotic agent. Opioids bind to the opioid receptors that are present in the central nervous system and peripheral nervous system and produce their therapeutic effects. Opioids are the morphine like synthetic drugs that produce the same effect as that of morphine for pain relief, respiratory depression, constipation and sedation. Opioids antagonists block the (µ , ? and ?) opioid receptors. (Flomenbaum et al. 2006). Opioid antagonists, when administered before treatment, block the opioid agonists by preventing their action. They also reverse the effect of...
8 Pages(2000 words)Essay
Naloxone's Drug Profile
...Naloxone’s Drug Profile Section Part One Naloxone helps in reversing opioid effects like hypotension, depression,and respiratory sedation. It can also reverse constipation associated with opioids. When administered orally, Naloxone has a bioavailability ranging from 1.9 per cent to 2.2 per cent for the 20 milligram and 120 milligram oral doses. The bioavailability is low due the significant first-pass hepatic metabolism (O’Malley-Dafner 7; Davies 722-3). Part Two Orally administered, Naloxone undergoes a wide metabolism in normal subjects. It is minimally absorbed when given orally as it is quickly destroyed in the GI tract. Many greater doses are needed when using oral administration for any...
7 Pages(1750 words)Essay
Profile
...?Profile Instruction: Task: Aysha Janahi is an interesting studying Media Communication at his second year. He is a particularly interesting target for this profile exercise for many reasons that include his gentility in tackling pressing matters. Additionally, the fact that Aysha came from conservative Bahrain and sought schooling in the liberal American education is an illuminating indicator of a flexible young person (Stein & Paterno 2001, p. 56). In other words, the student actively displays the character trait of a young man willing to experiment with culture, customs and traditions of foreigners in order to discover meaningful integration. Therefore, his choice to make appearance in this...
3 Pages(750 words)Essay
Drug Profile Paper
...? Abused Substances There are several substances which are abused in different capacities by people in attempt to achieve various luxuries. Most of these substances are addictive and once you start using them, it may need a lot of stress to overcome. Continuous abuse of these substances always leads to negative consequences which can even lead to loss of lives and reputation in social set up. These abused substances fall under different categories due to the nature of their origin and how they affect humans when abused and are discussed below. Stimulants These are drugs that make a person feel more alert and they occur naturally in many plants. Example is caffeine found in tea, coffee and chocolate which are readily...
6 Pages(1500 words)Essay
Drug Profile Chart
...of Phoenix Material Drug Profile Chart Address the four categories of depressants, stimulants, narcotics, and hallucinogens. For each category, identify specific substances within it, street names, methods of administration, addiction potential, paraphernalia, what effects you might observe in the workplace with a user of this substance, withdrawal symptoms, and treatment possibilities (be sure to list both homeopathic and allopathic where applicable). Include a reference page citing your resources, and include sources other than websites. DRUG STREET NAME(S) METHODS OF ADMINISTRATION (include user paraphernalia) POSSIBLE EFFECTS (include physiological effects, addiction potential, and...
2 Pages(500 words)Essay
Drug Profile activities for Module 2
...Drug Profile Activities for Module 2 Drug Profile Activities for Module 2 Comparing Levosalbutamol and Racemic Salbutamol in the treatment of acute exacerbation asthma (Punj, A., Prakash A., and Bhasin A. 2009. Levosalbutamol Vs Racemic Salbutamol in Treatment of Acute Exacerbation of Asthma, Randomized Double blind clinical study. Indian Journal for Pediatrics. Vol. 76(11), pp.1131-1135.) Type of Study: randomized double blind clinical study. Comparable agent: racemic salbutamol. Sample size: 60 children suffering from exacerbation asthma. Measures of effectiveness: levosalbutamol appears to be more effectual. Than racemic salbutamol in terms of improving PEFR, SPO2 and asthma score. In the racemic salbutamol, deleterious effect... score,...
2 Pages(500 words)Research Paper
Profile
...Personality Profile: Gary Desir Gary Desir is not your typical college He may sport as a typical but there is more than him that meets the eye. He may frequent the club as any young man his age or immersed in movies and music as anybody would do, but that is not all him. He may look like a social butterfly but he knows his priority – to get an International Business Degree from Johnson and Wales University. H ecould play tought being a football player, but he is more than the sport. He does all this and having fun because he wants to make the most out of life but he does not lose sight of his goal. As he said “eyes on the price” meaning not to forget the degree even if he indulges with what life can offer. He may look like...
1 Pages(250 words)Essay
Drug Abuse / Drug Addiction
... Drug Abuse Drug Addiction Introduction The world, today, has become surrounded by drug abuse as well as drug addiction. This escalating disorder has become so common, that its truth is based on misconceptions that people have concerning drug abuse as well as addiction. This paper briefly provides an overview of drug abuse as well as addiction, and at the same time looks at the aspects of epidemiology, social problems, pathophysiology, as well as ethical issues that might arise with medical emergency responders. Drug abuse and drug addiction; exactly what does that imply and who is affected by it? There is confusion between drug addiction and abuse. Drug abuse happens when there is the usage of a substance, generally illicit drugs... or...
8 Pages(2000 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic Drug profile for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us