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Virulence Factors of Candida Albicans - Case Study Example

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This paper "Virulence Factors of Candida Albicans" discusses Candida Albicans as a general component of human gut flora and can stay with no evil effects. This commensal organism is generally found in skin, oral cavity, gastrointestinal and genital tracts…
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Virulence Factors of Candida Albicans
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Download file to see previous pages  The virulence factors are all the factors that are related in the process of morphogenesis, adhesion, penetration, and colonization of Candida in tissues and blood vessels. Since the hyphal form is often associated with infection, the understanding of hypha-specific cell surface components may help in the identification of the proteins responsible for morphogenesis and virulence. Fungal infection can be treated by the prevention of hyphal development in C. Albicans by antifungal drugs. Understanding Candida biology, genetics, and molecular mechanisms may lead to novel effective antifungal therapy for drug-resistant organisms.

With the help of this strategy, it can survive and grow on the skin, mucosal surfaces and also in vascular systems. This flexible strategy adapted by the organism exhibits difficulty in treating fungal infection. Serious, life-threatening systemic fungal mycoses is a leading cause of mortality in immunosuppressed patients (Odds 1994).

Morphogenesis is a reversible interconversion between unicellular and multicellular growth pattern. C. Albicans produce a variety of shapes of the cells depending on the environmental conditions. This interconversion ability in response to external stimuli is rapid. C. Albicans exist in two main recognizable morphological states, yeast, and hypal forms, so this organism is broadly referred to as ‘dimorphic fungus’. C. Albicans usually exist in unicellular yeast form which reproduces by forming buds, by a mitosis process. In the hypal mode, there is a continuous apical growth which leads to an elongated tube-like structure. This filamentous growth is multicellular, where cells are separated by septa. ...Download file to see next pagesRead More
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