The Role of Amino Acid R-groups to the Structure and Function of Ligand-Protein Complexes - Lab Report Example

Biologically proteins functions well when stable hence the need for enzymes that helps in maintaining their stability (Bruylants). The folding of proteins takes place mainly while they are biologically active. This knowledge is widely employed rational drug design, and biopharmaceutical production in developing stable proteins for various production and function. The process is not as easy as it may look since it requires the knowledge of correct folding and the amount of forces required during the folding process.

Ability of folding of proteins, which forms basic units of amino acids can be measured using several detectable and analytical machines and instruments. Ligand is a molecule that is always targeting a protein site leading to binding. The process of binding is through various forces such as van der Waals forces, ionic bonds, hydrogen bonds, and intermolecular forces (Baron). The process of binding has an effect of altering the shape of the ligand. The process of binding and coming together is known as affinity.

The ligand binding affinity power depends on the type of forces that exist in the process and the amount of the intermolecular forces existing in the chemical molecule. Longer distance While looking at the difference of these amino acids it is important to look at the molecular weight and their structures, which transforms to the rate to front between these amino acids . Cysteine has a molecular weight of 121.1150 and the only binding factor is the sulphur molecule, which does not give it any much more weight.

Alanine has the last weight with 89.0935 due to the possession of only three carbon molecules and a carboxylic group. Serine has 105.0930 weights and has four carbon molecules, which increases the tie for rate to front. Aspartic acid has the highest weight of 13.1032 since is possess the amino group. In addition to this, the amino acid also contains the carboxyl group, which reduces its rate