quora
Nobody downloaded yet

Anti Cancer Drugs - Essay Example

Comments (0) Cite this document
Summary
G0 phase of the cell cycle is also called the resting phase which is the non-dividing phase of the cell. The next phase is G1 during which the cell…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.1% of users find it useful
Anti Cancer Drugs
Read TextPreview

Extract of sample
"Anti Cancer Drugs"

Download file to see previous pages Cell cycle phase specific anticancer drugs are given for a particular phase and inhibit the further progression of the tumor cell (Ajithkumar et al 2011). The G1 phase specific drugs inhibit the G1 phase of the tumor cells and have therapeutic consequences associated with them.
Cyclin-dependant kinases play an important role in the progression of the G1 phase. During the G1 to S phase transition, the phosphorylation of retinoblastoma susceptibility gene, Rb, regulated by D-type cyclins and CDKs 4 and 6 is a major factor causing the cell cycle progression. By inhibiting the CDK activity, the G1 phase activity can be inhibited as well. First generation CDK inhibitors include flavopiridol, UCN-01 and L86 8276, a non-chlorinated chemical form of flavopiridol. Flavopiridol causes G1 inhibition by its inhibitory action on the CDK 2 and CDK4. UCN-01 and flavopiridol cell cycle repression is followed by apoptosis of the tumor cells and they cave a cytotoxic effect. However, tumor cell selectivity is a major issue in their therapeutic affectivity. Non-tumor cells can also be affected by these anticancer drugs leading to apoptosis and hence, non-tumor cells are also sensitive for the CDK inhibiting action (Shapiro & Harper 1999).
The limited inhibition activity caused by first-generation lead to the formulation of purvalanol B a second generation CDK inhibitor. This drug targets the ATP-binding sites and has shown higher selectivity for the CDKs. The activity of CDK4 and CDK 2 is inhibited 100-folds more selectively causing inactivation of Rb gene and ultimately cell arrest at the G1 phase (Shapiro & Harper 1999). Corticosteroids and natural products like asparagine are also specific for cell arrest at G1 phase of the tumor cells. Corticosteroids are effective in lymphoid derived tumors while asparagines are effective in depriving the tumor cells ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Anti Cancer Drugs Essay Example | Topics and Well Written Essays - 500 words”, n.d.)
Anti Cancer Drugs Essay Example | Topics and Well Written Essays - 500 words. Retrieved from https://studentshare.org/biology/1589243-anti-cancer-drugs
(Anti Cancer Drugs Essay Example | Topics and Well Written Essays - 500 Words)
Anti Cancer Drugs Essay Example | Topics and Well Written Essays - 500 Words. https://studentshare.org/biology/1589243-anti-cancer-drugs.
“Anti Cancer Drugs Essay Example | Topics and Well Written Essays - 500 Words”, n.d. https://studentshare.org/biology/1589243-anti-cancer-drugs.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
THE ROLE OF CONTROLLED DRUG RELEASE IN CANCER THERAPEUTICS
The disease is also known as malignant neoplasm since the cells grow continuously without control forming malignant tumours (Wolinsky, Colson and Grinstaff 2012, p.444). Cancer cell fail to follow the normal cell cycle, whereby after sometime the cell needs to die, a process called apoptosis (Blanco Hsiao, Mann, Landry, Meric-Bernstam and Ferrari 2011, p.342).
10 Pages(2500 words)Essay
Anti-hypertensive drugs
“Hypertension is usually defined as a systolic pressure above 140 mm Hg and a diastolic pressure above 90 mm Hg.”. The risk of hypertension increases with the advancement of age. The principle cause of stroke is hypertension because increased blood pressure causes hypertrophy and other changes in the vasculature of the left ventricle. Furthermore, hypertension increases the risk of coronary artery disease and renal failure.
14 Pages(3500 words)Essay
New Approach in Cancer Treatment
Its current devastating effects have caught the attention of the world health organization and other global health forums. Much of what scientists know about cancer surrounds the fact that cancer cells have a hyperactive division rate and proliferate to large numbers in a short period.
12 Pages(3000 words)Essay
Cancer
Cells are naturally designed to multiply in a controllable manner, failure to which a cancer may develop. The uncontrolled cell multiplication can be attributed to mutation of genes (a molecular unit in our DNA, which contains information of how cells operate).
5 Pages(1250 words)Essay
Lung Cancer
Environmental, or second-hand, tobacco smoke is also implicated in causing lung cancer. Beta-carotene which serves as an antioxidant help deactivate free radicals, unstable molecules that are the by-products of cells "burning" oxygen for energy when used by smokers increases the risk of lung cancer and when used by a non-smoker prevents heart diseases.
3 Pages(750 words)Essay
Using current primary literature, discuss the aromatase-inhibiting anticancer drugs
Estrogens play a key role in the development and growth of breast tumors. Hence, estrogen is a key target in breast cancer drug developments. In order to understand the rationale, structure and mechanisms of AI drugs, it is necessary to provide an overview of the structure,
6 Pages(1500 words)Essay
Specific Disease Site Of Clinical Oncology: Ovarian Cancer
The problem lies in the detection of this ailment as only about 25% cases are diagnosed successfully in the initial stages. It has been estimated that the chance of ovarian cancer increase with age. A complete profile can be created taken the basis of risk factor involved of being diagnosed with ovarian cancer.
5 Pages(1250 words)Essay
The anti-Cancer activity of Rhein in Leukaemia
The excessive proliferation of the white blood cells results in increase in the viscosity of the blood and thus increased stress on the cardiac
28 Pages(7000 words)Essay
A new technology that is revolutionizing the healthcare with examples from journals or magazines
Besides quality health care, medical technology has a significant contribution to the economy. This paper will discuss 3-D printing as the new technology that is revolutionizing health care in the modern health set up. 3-D printing is among the latest
1 Pages(250 words)Essay
Cancer effectiveness of drugs in its treatment
Time has changed now; radiotherapy, chemotherapy, operation in certain cases and medicine are now leading a hard battle against this disease (ITIK', Uymaz, Stephen, and BANKS, 715). Before moving into details regarding the efficiency of drugs combating cancer, it would be better if a brief and clear overview of the disease can be obtained. In most simple terms cancer is an uncontrolled growth of cells that might happen at any place of the body.
5 Pages(1250 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic Anti Cancer Drugs for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us