quora
Nobody downloaded yet

Role Of Notch Signaling In Oncogenesis - Essay Example

Comments (0) Cite this document
Summary
Notch signaling pathway is an important intercellular signaling mechanism which is present in all metazoan organisms. The research "Role Of Notch Signaling In Oncogenesis" demonstrates the role of Notch signaling in oncogenesis that can help the development of more novel cancer treatments…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER92.1% of users find it useful
Role Of Notch Signaling In Oncogenesis
Read TextPreview

Extract of sample
"Role Of Notch Signaling In Oncogenesis"

Download file to see previous pages Extensive research in notch pathway has identified either dysregulation or faulty signaling in cancers and many other diseases like multiple sclerosis, tetralogy of Fallot and Alagille syndrome. Because Notch signaling pathway is involved in the progression and development of several malignancies, it is considered a novel therapeutic target and if the research on this aspect is fruitful, it can have the highest therapeutic impact in modern clinical medicine (Wang, Li, Banerjee and Sarkar, 2008).The Notch signaling pathway The most important constituents of the Notch signaling pathway are the receptors. There are basically four types of Notch receptors which are single- pass transmembrane receptor proteins. They are Notch1 through Notch 4. Each of these is a heterodimer which is proteolytically cleaved and lies at the surface of the cell. The receptor is made up of 2 domains, the ectodomain and intracellular domain. Both these domains are associated in a calcium dependent, noncovalent interaction. Ectodomain is large and constitutes the outside part of the cell surface. The intracellular domain is smaller and tethered to the membrane. The ectodomain part of Notch receptors interacts with certain ligands of adjacent cells. These ligands belong to Jagged and Delta- like families and are named as JAG1, JAG2, DLL1, DLL3, and DLL4. The interaction between the receptor and ligand induces a couple of proteolytic cleavages causing the release of the intracellular domain part of the receptor from the cell membrane. ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Role Of Notch Signaling In Oncogenesis Essay Example | Topics and Well Written Essays - 2250 words”, n.d.)
Role Of Notch Signaling In Oncogenesis Essay Example | Topics and Well Written Essays - 2250 words. Retrieved from https://studentshare.org/biology/1551686-role-of-notch-signaling-in-oncogenesis
(Role Of Notch Signaling In Oncogenesis Essay Example | Topics and Well Written Essays - 2250 Words)
Role Of Notch Signaling In Oncogenesis Essay Example | Topics and Well Written Essays - 2250 Words. https://studentshare.org/biology/1551686-role-of-notch-signaling-in-oncogenesis.
“Role Of Notch Signaling In Oncogenesis Essay Example | Topics and Well Written Essays - 2250 Words”, n.d. https://studentshare.org/biology/1551686-role-of-notch-signaling-in-oncogenesis.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
APN Role
Contextually, this paper would analyse the core competencies of APN that enable them to deliver noteworthy results. Furthermore, the purpose of the paper would also comprise exploration of a particular research study related to the unique contribution of APN and deliver an outcome plan to enhance their treatment approaches.
5 Pages(1250 words)Essay
Role of Cytokine Signaling during Nervous System Development
Cytokines are liberated by various cells and are utilized extensively in the intercellular communications to bring out diverse activities, admitting complex processes involved in the ontogenetic growth of the brain. This article basically is a review that illustrates the factors that are engaged in the regulation of brain growth as well as discusses the current findings searching the signaling pathways of cytokines during the progression of central nervous system.
3 Pages(750 words)Essay
Alumni Role
Lei-Chun Fung, MPH, MSW, Health Educator. At the onset, I adapted to the facility and my supervisor began dispensing my services. The experience is a deemed as a continuous learning process where I imbibe the
1 Pages(250 words)Essay
Role Models
Role models inspire others to undertake changes and work towards newer goals. Useful quotes- “role models who support worthwhile causes and who are willing to act on their beliefs help children develop and strengthen their own values” (Silver). “Good
3 Pages(750 words)Essay
Role play
The primary objective of reengineering is to increase the quality of healthcare at the lowest cost. Nurse leaders play a vital role in system re-engineering since they are among the decision makers in a health institution. Nurse leaders are
1 Pages(250 words)Essay
Estrogen Signaling
Nuclear receptors are very important for the functioning of various molecules in our body. They are basically proteins found in the interior aspects of the cell. They sense the presence of small lipophilic molecules like steroids and various other hormones and regulate the expression of the genes concerned to these molecules.
8 Pages(2000 words)Essay
Role model
Many regular people see famous people as role models in their life, and these role models influence the way that other people think. One of the most famous people in the world that has been considered by many people in society as a role model is Mahatma Gandhi. He
3 Pages(750 words)Essay
Role Reflection
The article identifies an ongoing problem in the schools regarding the implementation of curriculum and principals role in it. The problem is that principals do not ensure proper implementation of curriculum in schools. Money is invested in
2 Pages(500 words)Essay
Dividend Policy decisions and Capital Structure decisions in relation to Signaling THeory
According to Michael Spence, two parties could solve the problem of asymmetric information when one party sends a signal revealing some piece of relevant information to the other party (Spence 355).
2 Pages(500 words)Essay
The Role
In theory, civic engagement includes the dimension of community life in its content. Due to the classification provided by Adler and Goggin (2005), the analyzed concept has several appearances;
3 Pages(750 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic Role Of Notch Signaling In Oncogenesis for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us