quora

Cancer at the molecular level - Essay Example

Comments (0) Cite this document
Summary
Cancer at Molecular Level Introduction Cancer, also known as malignant neoplasm, the hallmark characteristic involves uncontrolled proliferation of cells. Under normal conditions cell grow, divide and die, but in cancer cells the defect takes place at the gene level leading to the formation of an abnormal DNA…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.8% of users find it useful
Cancer at the molecular level
Read TextPreview

Extract of sample
"Cancer at the molecular level"

Download file to see previous pages (Normal cell cycle) (Genetic mutation- causes alteration in genes) (Alberts, 2007) Cancer is a genetic phenomenon that onsets as a result of trigger in the signal transduction of normal cell cycle, causing alteration in the cellular pathway for uncontrolled proliferation figuring malignant tumors. Cancer cells are not confined to one location and they turn invasive, spread to the nearby tissues initially and gradually their seedlings are carried to different parts/ organs of the body via lymph or blood causing invasion of the cancer to other tissues and organs. This stage is called metastasis. On the contrary, some cancer cells do not display uncontrolled growth, they are non-invasive and do not spread, such stage of cancer only forms benign tumors (Alberts, 2007). Cancer Proliferation Cancer is initiated in the cell, the basic unit of any living entity. Under normal conditions the cell follow the regular cell cycle but any chemical, physical or biological agent may trigger the conversion of proto-oncogene to oncogene, the active form of cancer causing gene which is responsible for the altered metabolism of the cell. The genetic basis of cancer has been revealed through numerous animal models. The human Genome Project aids in improving preclusion, analysis and management of cancer with better efficacy (Luo, 2008). Luo et al (2008) have identified essential genes in 12 cancer cell lines, they were exploited to find the presumed and established oncogenes such as KRAS, EGFR, MYC, MYB, BCR-ABL, CDK4 and CRKL that are vital for cancer cell proliferation and are found to be altered in the human cancers. Their findings postulate that tumoricidal agents trigger the expression of four genes PTPN1, NF1, SMARCB1, and SMARCE1. Moreover, five regulators are also activated in response to FAS activation, FAS, FADD, CASP8, ARID1A and CBX1. The information is beneficial for pursuing future cancer studies as well as for therapeutics. A comparative study between normal stem cells and cancer stem cells states that signal transduction namely Bmi1 and Wnt are shared by the normal as well as cancer stem cells for cellular proliferation. Perception and thorough understanding for cancer stem cells will certainly aid in recognition of the drug targets and cancer therapeutics (Lobo, 2007). Basis of cancer Any mutation may result in abnormal proliferation. However, mutations are generally insignificant and mutant cells are eradicated but accretion of mutation may occur in dividing cells resulting in cancer. Cancer causing mutation directly influence the cellular machinery including the genetic damage as well as signaling pathways and hence the entire cell division process is affected. As stem cells are pluripotent, long-lived as compared to their short lived descendant cells, they are vulnerable to the genotoxic elements causing oncogenic mutations (Pardal et al, 2003). Observations reveals that cancer tends to relapse after treatment. The genetic basis that has been postulated encompass the involvement of cancer stem cells. Research disclose that cancer stem cells play a pivotal role in cancer relapse as stem cells are not targeted by the conventional drugs and as these cancer stem cells are pluripotent they have potential to divide thereby generating tumor again. Much understanding of the cancer could be procured ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Cancer at the molecular level Essay Example | Topics and Well Written Essays - 1000 words”, n.d.)
Retrieved from https://studentshare.org/biology/1494091-cancer-at-the-molecular-level
(Cancer at the Molecular Level Essay Example | Topics and Well Written Essays - 1000 Words)
https://studentshare.org/biology/1494091-cancer-at-the-molecular-level.
“Cancer at the Molecular Level Essay Example | Topics and Well Written Essays - 1000 Words”, n.d. https://studentshare.org/biology/1494091-cancer-at-the-molecular-level.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
What Causes Cancer Mutations
What Causes Cancer Mutations? Cancer is known as malignant neoplasm, the hallmark characteristic involves uncontrolled proliferation of cells. Under normal conditions cells grow, divide and die, but in a genetic defect called mutation occur in cancer cells leading to the formation of an abnormal DNA.
6 Pages(1500 words)Essay
Breast Cancer
Breast cancer is the more common type cancer among American women and is one of the leading causes of death in the United States (Weaver, 2007). For instance, in 2007, experts estimated placed at 240,000 people, including men, who will be victims of cancer in the United States for that year (Weaver, 2007).
5 Pages(1250 words)Essay
New Approach in Cancer Treatment
Its current devastating effects have caught the attention of the world health organization and other global health forums. Much of what scientists know about cancer surrounds the fact that cancer cells have a hyperactive division rate and proliferate to large numbers in a short period.
12 Pages(3000 words)Essay
Breast MRI
It is also used in examining the extent of chest wall invasion in breast cancer patients with posterior carcinomas, and the diagnosis of breast cancer in women portraying normal mammographic examinations and presence of axillary metastasis (Torosian 2002, p.
7 Pages(1750 words)Essay
Critical Review of a molecular cancer article
In trying to determine whether the approach to the study was appropriate or not, this review will base the rationale of the critique arguments on the reverse transcriptase PCR, immunolocalization of hCG,
3 Pages(750 words)Book Report/Review
Molecular Therapeutics
Hamberg and Samuelson were eventually able to clearly elucidate the mechanism of prostaglandin biosynthesis in 1967 (Lawrence, et. al.1999). It became clear, afterwards, that prostaglandins were formed from polyunsaturated fatty acids by a complex reaction involving oxygenation, cyclization and the generation of five chiral centres from an achiral substrate (Lawrence et al 1999).
6 Pages(1500 words)Essay
Molecular Identity
These are all sodium/potassium-coupled chloride cotransporters described succinctly below. They can be functionally classified broadly into four groups according to the cation coupling to the chloride ion, the stoichiometry of the transport process and the relative sensitivities to inhibitors.
12 Pages(3000 words)Essay
Researching Cancer
al, 2005). This process typically requires the breast cells to divide and multiply in order to replace the old/injured cells in the breast. This process of cell division is stimulated by a hormone
2 Pages(500 words)Essay
Cancer dedection
ly small particles, devices which will are capable of interacting at the cellular level (Srinivas et al, 2002,) and is a potential tool for early detection of cancer. Nano-tools can be successfully used for proper detection of cancerous or even precancerous cells in the body
2 Pages(500 words)Essay
Molecular Biology
Monoclonal antibodies can be obtained by intraperitoneal injection into mice and collection of ascetic fluid produced. Since it is difficult to to remove antigenicity from the mouse, in vitro
8 Pages(2000 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic Cancer at the molecular level for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us