quora
Nobody downloaded yet

The role of microRNAs in breast cancer - Essay Example

Comments (0) Cite this document
Summary
The Role of MiRNA in Breast Cancer Name Institution Date Introduction MicroRNAs are non-coding RNAs that exist naturally and use mRNAs translational cleavage or repression to control gene expression. MicroRNAs have been associated with breast cancer as a causative factor and as a means to solving the problem (Yamashita et al, n.d., p…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER97.8% of users find it useful
The role of microRNAs in breast cancer
Read TextPreview

Extract of sample
"The role of microRNAs in breast cancer"

Download file to see previous pages Below is a description of the effect of miRNAs in breast cancer metastasis, treatment and cause. Regulation on Cancer Causing Proteins According to Yamashita and others, mis-expressions or mutations in miRNA have been associated with different types of human cancers. The loss-or-gain-of function of some miRNAs has also been found to contribute to tumorigenesis and epithelial cellular transformation of the breast. Research has also revealed that profiling of miRNA expression shows that different molecular subtypes in breast cancer have different expressions of miRNAs (Yamashita et al, n.d., p. 331). ER? is responsible for breast cancer. There are two types of ER? related breast cancers. There are ER?-negative and ER?-positive breast cancers. Most primary breast cancers express ER? with an approximate value of 70%. ER?-positive breast cancers have been found to respond positively to endocrine therapy. This could be because of the role of ER? in the endocrine system. ER? is necessary for estrogen-dependent growth. It affects the response to endocrine therapy among women with ER?-positive breast cancers depending on its level of expression. ...
331). The Roles of miRNAs in Cellular Processing There are various cellular processes in which miRNAs are involved. These include development of skeletal and heart muscles, and establishment and maintenance of cell lineage. The miRNAs have the ability to express specific tissue, which has been, observed in insulin secretion, proliferation, hematopoiesis, adepocyte development, apoptosis, and brain pattering. Because of these roles and involvement in diverse cellular functions, miRNAs’ function and expression dysregulation has the potential to cause diseases. This has been observed in Tourette’s syndrome, fragile X syndrome, and from recent research studies, associated with cancer development and progression (Kayani, Kayani, Malik & Faryal, 2011, p. 3175). Bachour and Bennett (2011) also note that miRNAs are involved in regulation of apoptosis, proliferation and differentiation, and have the ability to directly obstruct stability and translation of specific gene transcripts that they target and cause cell physiology disorder. In breast cancer, for example, miRNAs have been found to be involved in the dysregulation of tumor suppressor genes and oncogenes, causing progression of breast cancer (Bachour & Bennett, 2011; Liu et al, 2011). MiRNAs are also found in regulation of cell development and cell cycle. This characteristic places them in the best place for exploring anticancer treatments. Altered miRNA signatures cause breast cancer metastasis and development. This has been identified through the study of the effect of the loss of tumour suppressor miRNAs such as miR-31, miR-203, miR-30a, miR-34a, miR-200s, miR-205, miR-342, miR-125s, miR-206, and let-7s, or the over-expression of oncogenic miRNA such as miR-21, miR-155, miR-222, miR-10b, ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“The role of microRNAs in breast cancer Essay Example | Topics and Well Written Essays - 1750 words”, n.d.)
Retrieved from https://studentshare.org/biology/1469748-the-role-of-micrornas-in-breast-cancer
(The Role of MicroRNAs in Breast Cancer Essay Example | Topics and Well Written Essays - 1750 Words)
https://studentshare.org/biology/1469748-the-role-of-micrornas-in-breast-cancer.
“The Role of MicroRNAs in Breast Cancer Essay Example | Topics and Well Written Essays - 1750 Words”, n.d. https://studentshare.org/biology/1469748-the-role-of-micrornas-in-breast-cancer.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
Breast Cancer
Breast cancer is the more common type cancer among American women and is one of the leading causes of death in the United States (Weaver, 2007). For instance, in 2007, experts estimated placed at 240,000 people, including men, who will be victims of cancer in the United States for that year (Weaver, 2007).
5 Pages(1250 words)Essay
Breast Cancer
According to the research findings it can therefore be said that breast cancer is an important malignancy in women because of its high incidence. The signs and symptoms of breast cancer are important to be understood by women as the early detection of the tumor plays an important role in better prognosis.
5 Pages(1250 words)Essay
Breast cancer
Breast cancer has got many risk factors. The majority cases of breast cancer are reported among women who are above 50 years. The cancer is known to occur is families with a history of the cancer (National Cancer Institute, 4). It is also common in the late cases of the first pregnancy and among kinsfolk with a history of benign breasts ailments and diseases.
3 Pages(750 words)Essay
Cancer Biology and MicroRNAs
Just like the DNA, the RNA is made up of coding and non-coding regions. The coding regions are responsible for gene expression. Looking at the central dogma and the transfer of a characteristic from the gene to the final protein, the genetic material is stored in the DNA which is then transferred to the RNA by transcription.
2 Pages(500 words)Essay
Breast Cancer
Estrogen is the hormone which supports the breast cancer to grow rapidly, but what actually causes breast cancer, is still a debate. However, hormones do play a big role in the growth of breast cancer. Studies have shown that breast cancer rate is high in those people
3 Pages(750 words)Essay
Breast Cancer
The lifetime risk for women to develop breast cancer is 12.03% or 1 out of 8 women based on the 2003 – 2005 data. (National Cancer Institute, 2009a) Since the was
3 Pages(750 words)Essay
Breast Cancer
Ethnic specific mutations of BRCA1 and BRCA2 are found in Ashkenazi (European) Jewish origin and in some families in Iceland, the Netherlands, and the Balkans. American Cancer Society has reported that breast cancer related deaths are
8 Pages(2000 words)Essay
Breast Cancer
The RNA polymerase needs other proteins in order to carry out the transcription process. Ensuring that transcription is adequately and properly carried out helps ensure cell growth and metabolism. Recently emerging studies point out that some adult cells may be affected and transformed into stem cells when a small number of transcription factors are added in (Takahashi and Yamanaka, 2006).
5 Pages(1250 words)Essay
Breast cancer
On the positive side, advanced treatment and drugs available for breast cancer, are saving many women’s lives and they are able to resume their normal life with minor ‘alterations’. Also, early detection can cure the woman in an effective
3 Pages(750 words)Essay
The role of immune therapy in breast cancer
Targeted therapy is the newest development in cancer treatment (Oldham and Dillman 2009; Immunotherapy n.d.). When breast cancer is considered, there are several
8 Pages(2000 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic The role of microRNAs in breast cancer for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us