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Response to a Research Paper Results Question 1 The research on the role of surgery in complete responders and the prognostic signi?cance of metabolic response in locally advanced esophageal squamous cell carcinoma establishes that the addition of surgery has higher DFS and LRFS rates than those of the PET?…
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Download file to see previous pages PET (Jeong et al 1). Out of the 154 patients, eighty?one patients received de?nitive CRT and 73 received trimodality therapy (Jeong et al 1). I feel that research presented enough data to help me judge for myself how the experiment turned out. Notably, the research presented data, which included criteria for determining which patients should receive de?nitive CRT rather than surgery after preoperative CRT (Jeong et al 1). Moreover, the research ensured that the 72 patients of the 73 patients under trimodality therapy underwent transthoracic esophagectomy and one underwent transhiatal esophagectomy to enhance clarity in analyzing the collected data and the results (Jeong et al 2). Additionally, there was a follow-up, which started from the beginning of the Radiotherapy thus enhancing uniformity and correctness of the research. This would be significant for me in judging how the experiment turned out. Notably, the researchers used the AJCC 6th edition TNM stage classi?cation and the multiple logistic regression analysis to determine the pathologic stage and the PET?CR to estimate the propensity score (Jeong et al 2). These methods present efficient, professional, and reliable data that is enough for me to establish how the experiment turned out. More so, the nonparsimonious model that addressed all the variables in the experiment derived significant data that would facilitate an independent opinion on the direction of the experiment (Jeong et al 2).The research presents data on the characteristics of the 154 patients, treatment response, and survival rates. The presented data is enough for me to make an informed decision on how the experiment turned out (Jeong et al 2). Question 3 The data mentioned by the author had a unique pattern. In fact, the data shows that all the 154 patients had squamous cell carcinoma with the majority of them being men (Jeong et al 2). Another pattern shows that 45 Gy was the mean total radiation dose in the preoperative CRT group while the 50 Gy was the mean total radiation dose in the de?nitive CRT group (Jeong et al 2). Furthermore, we can establish a superiority pattern where the rate of pCR was superior in the PET?CR group than in the PET?CR group (Jeong et al 2). More so, there was a treatment failure pattern where most of the 154 patients experienced treatment failure (Jeong et al 3). Another pattern was clear where local failure was the major failure site in the de?nitive CRT group while distant metastasis was the major pattern of failure in the trimodality group (Jeong et al 4). Another common pattern in this research was surgery being a signi?cant prognostic factor for LRFS in the entire patients (Jeong et al 3). Nevertheless, I can establish that the research did not address the problem of age with relation to surgery. Discussion Question 1 An analysis of the data in this research concludes that the addition of surgery showed higher DFS and LRFS rates than those of the PET?CR subgroup of de?nitive CRT patients (Jeong et al 5). More so, it concludes that PET?CR after CRT was a signi?cant prognostic factor for OS, DFS, and LRFS in locally advanced esophageal squamous cell carcinoma (Jeong et al 5). Ultimately, the research concludes that despite achieving PET?CR, surgery still seems to improve local tumor control (Jeong et al 5). The ...Download file to see next pagesRead More
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