What are the strengths and weaknesses of an artificial kidney based on the use of proximal convoluted tubule cells - Essay Example

In the search for alternative treatment of such diseases, kidney transplant emerged as the most viable option, which has been applied extensively. Nevertheless, despite kidney transplant being a successful option, the costs and the difficulty in finding the kidneys for transplant has promoted another alternative search, this time that entails the application of artificial kidney, based on the use of proximal convoluted tubule cells. This alternative is being widely studied and experimented, since it has shown some rays of hope that it might emerge as a viable alternative for addressing the problem.

The discovery of this bio-artificial kidney has shown some potential of saving the life of people who have acute renal failures (Fawcett, 2004 n.p.). The study undertaken with 10 patients with acute kidney problems indicated that the artificial kidney that is based on the use of proximal convoluted tubule cells, is well tolerated by the adult human body, and has the potential of improving their conditions (Fawcett, 2004 n.p.). However, despite this ray of hope, there is a need to understand how the bio-artificial kidney operates.

Therefore, this study seeks to investigate the viability of the bio-artificial kidney, with a view to understand the advantages and disadvantages of its application. First, the strength of this bio-artificial kidney is, that it will be the first device of its kind to be implanted inside the body of humans, as opposed to the use of dialysis machines, which are connected to the body externally, and are used to filter the body waste mechanically (Boyle, 2010 n.p.). Therefore, this device eliminates all the inconvenience that are involved in mechanical removal of wastes from the body, considering that the device will be implanted inside the body of a patient, and thus will be performing continuously, as does the normal kidney (Fawcett, 2004 n.p.).

The mechanical removal of human waste is associated with a lot of challenges. Most fundamental is the fact that; the patient is not continuously involved in the removal of body wastes, but has to do it occasionally as programmed through the use of the dialysis machine. This puts the patients at a higher health risk, since the wastes may accumulate at a rate that was not anticipated by the physician, and thus cause the intoxication of the human body, while he/she still awaits the mechanical removal of wastes (Boyle, 2010 n.p.).

It is in this consideration that the artificial kidney, based on the use of proximal convoluted tubule cells, is found to be advantageous, since it works like a normal kidney, without the need for programmable removal of kidney wastes. The application of this bio-artificial kidney eliminates the need to locate a patient close to a dialysis center, while also removing the need for them to undergo the extremely consuming procedure. The other strength associated with the use of the artificial kidney, based on the use of proximal convoluted tubule cells is that; this artificial kidney is developed using the normal biological kidney cells (Fawcett, 2004 n.p.).

The kidney is made up of a cartridge that is lined up with renal proximal tubule cells, which helps the kidney to operate like it was a normal kidney. This is because, the cells performs the most vital functions of the kidney, which is the filtration and separation of the kidney waste components from the vital electrolytes, salt, glucose and water, which are essential for the normal body functioning (Boyle, 2010 n.p.). Therefore, the artificial kidney prevents the loss of most important components of the blood system, which would otherwise have been lost through the