Nobody downloaded yet

Vancomycin and Preventing Infections - Dissertation Example

Comments (0) Cite this document
Vancomycin is a glycopeptide antibiotic that has bactericidal properties against gram-positive bacteria but not gram-negative bacteria. It is used to treat infections caused by most staphylococci, including the strains that are resistant to methicillin (MRSA – Methicillin Resistant Staphylococcus aureus), nafcillin, and penicillin…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER93.8% of users find it useful
Vancomycin and Preventing Infections
Read TextPreview

Extract of sample
"Vancomycin and Preventing Infections"

Download file to see previous pages Fig. 1: Tricyclic glycopeptide structure of vancomycin (Ouelette & Joyce, 2010, p. 207) The three-dimensional structure of vancomycin forms a cleft that allows it to bind to late stage PG intermediates that have a D-alanyl-D-alanine terminus (Corey et al., 2012). Vancomycin is selectively toxic since the sequences L-aa-D-aa-D-aa of the peptide PG intermediates are only found in the cell walls of bacteria. Fig. 2: Figure showing the PG intermediates and vancomycin with its cleft where it binds to the D-Ala-D-Ala terminus (Corey et al., 2012, p. 138) Hydrogen bonding between the vancomycin glycopeptide molecule and the peptides of PG intermediates results in the formation of stable complexes (Reynolds, 1989). This in turn leads to the inhibition of transglycosylation and transpeptidation reactions by two important enzymes as they fail to bind to the terminus due to steric hindrance. Because of this, the elongation of the glycan chain is inhibited. The mechanism of action of vancomycin thus involves the binding of a “bulky inhibitor” (vancomycin) to the substrate (D-alanyl-D-alanine terminus) outside the cell membrane because of which the active site of two bacterial enzymes (transglycosylase and transpeptidase) cannot align and bind to the substrate. This unique mechanism of action of vancomycin renders drug resistance by most bacteria difficult, unlike most other antibiotics (Reynolds, 1989). Vancomycin Usage Vancomycin is used to treat severe infections such as pneumonia, endocarditis, abscesses, and empyema caused by MRSA, and also for the treatment of patients allergic to cephalosporins and penicillins (Ouelette &...
Significant information exists for vancomycin use in the hospital setting, but not so much for outpatient and use in the community setting. Challenges to proper usage of vancomycin may be caused due to lack of patient education, minimal studies in relation to patient education and improper compliance with best practice guidelines. Healthcare workers can sometimes lack proper understanding on correct dosage for patients. After extensive literature review, it is clear that improper preventive application or incorrect utilization of vancomycin may lead to the increased incidence of vancomycin resistant bacteria. It is thus imperative for healthcare institutions, healthcare workers and patients to comply with best practices regarding treatment with vancomycin as it is one of the few remaining antibiotics that can be used for the treatment of infections with multiple drug resistant bacteria or in patients with allergies to other common antibacterial agents. ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Vancomycin and Preventing Infections Dissertation”, n.d.)
Vancomycin and Preventing Infections Dissertation. Retrieved from
(Vancomycin and Preventing Infections Dissertation)
Vancomycin and Preventing Infections Dissertation.
“Vancomycin and Preventing Infections Dissertation”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Thesis proposal about antibiotic resistance pathogens in fomities
In modern time the extensive use of antibiotics in treatment of bacterial infections has led to some organisms developing resistance to some antibiotic. Antibiotic resistance can be defined as a form of drug resistance in which the targeted microorganisms can resist exposure to the same drug (Hawkey, 3) Spontaneous genetic mutation in bacteria may confer resistance to microbial drug.
8 Pages(2000 words)Dissertation
Infection Control Programme in Intensive Control Unit in Indian hospital
The study attempts to find out if there is a written infection control policy addressing standard practices of hand hygiene, sterilisation & disinfection and waste management and verifies its effectiveness based on participants’ responses to the questions asked about those standard practices. It also investigates the staff’s awareness and behaviour about the policy implementation.
92 Pages(23000 words)Dissertation
Vancomycin-Resistant Enterococci and ambulation ( evidence based practice )
A team of stakeholders can also be selected to address the practice problem. This change would involve collecting internal data about the practice, collecting data that can be accessed externally for benchmarking with the internal data; refining the practice problem statement by linking the problem with possible interventions and what is expected as an outcome.
11 Pages(2750 words)Dissertation
Nurses Role in preventing pressure Ulcers
On the other hand, pressure ulcer refers to an area of unrelieved pressure on a specific area, which results in ischemia, cell death and tissue necrosis (National Institute for Health and Care Excellence, 2013). There are several reasons pressure ulcer is the topic of choice for this paper.
24 Pages(6000 words)Dissertation
Preventing the spread of clostridium difficilel (C.diff) through Systems Change
Although CDD is also responsible for nosocomial outbursts of diarrhoea as well as colitis, antibiotic associated diarrhoea (ADD) is partially featured as inconsistency of intestinal microflora. The spread of Clostridium infection and its prevention is the major concern to check amplification of nosocomial infections, as most of the out breaks are accredited to Cl.
5 Pages(1250 words)Dissertation
A Systems Change: Preventing the spread of Clostridium Difficile by improving handhygiene compliance
difficile) is “a gram-positive, spore forming anaerobic bacillus” that causes nosoconial diarrhea and pseudomembranous colitis1 each time toxins A and B are released in the human intestinal tract (Giesemann, Egerer, Jank, & Aktories, 2008; Cookson, 2007; Hecht, 2003, p.
4 Pages(1000 words)Dissertation
Chlamydia Trachomatis infections among ethnic groups aged 15 to 24 in Miami, Dade, Florida
This paper offers an introduction to the dissertation, ‘Chlamydia trachomatis infections among ethnic groups aged 15 to 24 in Miami, Dade, Florida’. The introduction includes preliminary information on the subject locality, problem statement, reason for the research, research questions, significance of the research, definition of terms, and involved challenges.
8 Pages(2000 words)Dissertation
Diabetic Foot Treatment
The study concluded that aggressive treatment used in Orsett Clinic showed a significant improvement in metabolic parameter results of the patients. Lowering of HbA1c, total cholesterol, blood pressure and grade ulcer level demonstrated a remarkable improvement among diabetic patients after discharge.
50 Pages(12500 words)Dissertation
Chlamydia Trachomatis infections
‘Relationship between Chlamydia ‘Trachomatis’ infections and ethnic groups, and the 14- 24 age group in Miami Dade Florida’ will be the suitable working title for the thesis. This title suits the thesis topic whose scope includes the infections, ethnic groups, and the age bracket of 14 – 24 years in Miami Dade Florida.
2 Pages(500 words)Dissertation
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Dissertation on topic Vancomycin and Preventing Infections for FREE!
Contact us:
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us