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Radiation Absorbed Dose From 201 TI Thallous Chloride - Case Study Example

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The paper "Radiation Absorbed Dose From 201 TI Thallous Chloride" describes that when mice were administered 202Tl via intratesticular injection, Rao et al6 found a 2- to 4- fold increase in the effect on spermatogonia from electron emission measured by the Auger counter…
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Radiation Absorbed Dose From 201 TI Thallous Chloride
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Download file to see previous pages Thomas SR, Stabin MG Castronovo FP, Radiation-Absorbed Dose from 201Tl-Thallous Chloride. Journal of Nuclear Medicine Vol. 46 No. 3 502-508. 2005 by Society of Nuclear Medicine. 02-03-06. <http://jnm.snmjournals.org/cgi/content/full/46/3/502> Radiation dosimetry for 201Tl-thallous chloride has been developed by several authors1. The International Commission on Radiation Protection (ICRP) dose estimates for 201Tl chloride have incorporated values of testicular uptake published by Gupta et al2 and Hosain and Hosain.
1. There is a problem when dosimetry is calculated in this way: the values for testicular uptake at 24h reported by these authors for adults are significantly higher than those reported by other authors e.g., Atkins et al, Krahwinkel et al., Rao et al.
4. Further, the authors estimated the possible contribution to radiation dose from several radioactive contaminants that are often present in 201 Tl preparations, and have evaluated the consequence of administration time relative to preparation.
1. The uptake of 201Tl in the testes after intravenous administration of an isotonic solution is not as high as estimated in some studies, which have formed the basis for the recommendation of radiation dosimetry by the ICRP.
2. Since these data have been used to estimate testes radiation dose in children, the corresponding values are also higher; the authors hypothesized that even these values need to be revised downwards.
3. When Thallous chloride is provided as an isotonic solution, the possible contaminants are 200Tl, 202Tl, and 203Pb. With longer shelf life, the contribution of 200Tl decreases whereas that of 202Tl increases.
The equipment necessary to perform this research are: (1)Diagnostic exercise myocardial scintigraphy (2)Quantitative testicular scintigraphy (3)Lead vinyl shield ...Download file to see next pagesRead More
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