Describe in detail how you would go about isolating and studying the expression of the gene which appears to render the Southern Region population subgroup in saudi Arabia resistant to Type 2 diabetes
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Among these are the genes encoding leptin, tumor necrosis factor-alpha and adiptonectin. These genes may be involved in the development of insulin resistance. Therefore, to address the potential genetic association between resistance to type 2 diabetes, it is important to assess whether individuals whose phenotype shows resistance to the disorder are genetically screened to see if differences exist between the structure and/or activity of adipocytokine genes in groups women with similar risk factors (viz. obesity) and markedly different incidence rates for diabetes. A subpopulation of Saudi Arabian women has been identified that is resistant to the development of type 2 diabetes, despite incidence rates of obesity at the same level as the entire population of women in Saudi Arabia. The purpose of this research was to identify whether or not there was a genetic basis to this phenotypic observation.
The present study involves a genetic assessment of the gene called resistin, previously identified in mice on chromosome 8 (Steppan et al, 2001). To study this gene in humans it was necessary to clone the gene. This process is initiated by a technique called fluorescent in situ hybridization (FISH). The mouse gene is used as a probe to identify the chromosomal location of its human gene counterpart. Since gene sequences are frequently homologous among different species, the related genes or orthologues can be used to identify similar genes in different species (Gregory & Hebert, 1999). The mouse gene is attached to a fluorescent probe and mixed with human chromosomal DNA that has been denatured (connverted to single stranded form). The fluorescent band identifies the chromosomal location of the gene in humans. The chromosome segment can then be cut with restriction enzymes and linked to an expression vector to generate a recombinant
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Due to its association with old age, most people do not value preventive information. Nearly 50% of Saudis lack information on the dangers and causes of type II diabetes. The population also has a negative attitude towards healthy eating habits and physical exercise as a preventive measure.
Dear customer, I have edited the work as much as possible to meet the demands of your lecturer. However, I have had to rearrange the ideas to make the work well organised. The approach I used is as follows 1. Introduction 2. Explanation of type 2 diabetes 3.
Insulin is a hormone which is important in controlling and regulating the amount of sugar in the blood as it facilitates the absorption of glucose by cells in the liver, muscles as well as fat tissue, after which it is converted and stored by the liver in form of glycogen.
(Mycek, 2007). Diabetes is usually divided into two types, insulin dependent diabetes mellitus also known as type 1 diabetes mellitus and non-insulin dependent diabetes mellitus also known as type 2 diabetes mellitus or Adult onset diabetes. (Boylan, 2007) Type 2 diabetes is the most common form of diabetes accounting 85-90% of all people with diabetes.
The prevalence of diabetes is increasing, particularly in developing regions of the world, including Middle Eastern Countries. The social and economic consequences of this disease and its complications are enormous. The objective is to discuss the scope and implications of the increasing burden of diabetes and describe the rationale and design of a new international study examining blood pressure lowering and glucose control interventions aimed at reducing the risk of vascular complications in people with type 2 diabetes.
The insulin in your pancreas doesn't connect to the fat so the glucose cannot produce energy, causing hyperglycemia (high blood glucose). This cause the pancreas to produce more insulin and then the cells become more resistant causing a cycle of high glucose levels and often high insulin levels.
One is insulin resistance, and the other is progressive depletion of insulin reserve. Several studies have shown that once daily or twice daily insulin regimen started early on disease in type 2 diabetes with or without oral antihyperglycaemic agents serve to prevent hypoglycaemic events, to aid weight loss, and to produce better glycaemic control measured by blood glucose and glycosylated haemoglobin levels provided the patient can be educated and persuaded to accept insulin injections and an appropriate lifestyle modification.
This condition leads to a host of complications, the most dangerous and alarming of which is death. Various factors contribute to diabetes mellitus. Age, gender, genetic vulnerability, lifestyle, socio-economic factors, and environmental conditions are
Type II diabetes mallitus is a familial disease in some cases where it runs in families. In such cases, it is most commonly a result of weight gain. Obesity is a major risk factor for type II diabetes mallitus in those
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