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Cancer and How It Develops - Essay Example

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Cancer is characterized by the uncontrolled growth of cells, invasion of surrounding tissue and metastasis through which other locations in the body are affected. These characteristics differentiate a malignant tumor from a benign tumor which is an abnormal but localized tissue…
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Cancer and How It Develops
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Cancer and How It Develops

Download file to see previous pages... However a tumor on reaching a critical mass secretes chemicals to tempt blood vessels to invade the tumor to provide a channel for its nutrient supply and waste removal to support its uncontrolled growth. This also opens up a route for the cancer cells to metastasize or spread to other locations in the body through the blood and lymph vessels making surgical removal impossible. Chemotherapy or radiation is used to destroy metastasized cells.
Cancerous cells defy the control mechanisms that are placed to regulate cell division. In a normal cell cycle proto oncogenes and tumor suppressor genes in combination with each other regulate cell division. Proto-oncogenes promote the division of cells through its effects on growth factors or by producing them where as products of tumor- suppressor genes act in damage control such as repair and programmed cell death. Mutations in these genes results in malfunctions in cell cycle and leads to uncontrolled cell division giving rise to cancerous cells. Mutation in the tumor-suppressor gene p53 is associated with more than half known cancers. A protein produced by gene p53 regulates another gene whose gene product keeps a check on cell division. A mutation in p53 lifts that check resulting in uncontrolled cell division. Mutations in a proto-oncogene turn it to an oncogene which produces larger amounts of proteins (which are mostly growth factors or its receptors) or enhances the activity of the protein resulting in hyper stimulation of cell-division.
A distinguishing character of cancer cells is its lack of contact inhibition. They are devoid of anchorage unlike in normal cells that stop division on contact with neighboring cells through information from signaling systems.
Failure to trigger the mechanism of programmed cell death or apoptosis also is a characteristic of cancerous cells. The genetic suicide program is activated in normal cells in response to a physiological or biological signal in ...Download file to see next pagesRead More
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