The Negative Effects of Gluten in Food - Research Paper Example

The Negative Effects of Gluten in Food ABSTRACT In recent years, there has been a disturbing rise in the number of people diagnosed with obesity, osteoporosis, depression, celiac disease and non-celiac related food allergies. There has been much debate on the cause or causes of this alarming trend. One proposed answer is the negative effects of gluten in foods. In gluten sensitive people, gluten is perceived by the body as toxic and leads to digestive problems. The damage to the digestive system causes malabsorption of vitamins, minerals, amino acids and other nutrients. It also causes an inflammatory response in the immune system starts an attack against the body. As a result the gluten sensitive people fall victim to different diseases like obesity, osteoporosis, depression, celiac disease and non celiac related food allergies. Generally intestinal biopsy is conducted in people to detect if they are sensitive to gluten. Researches are underway to know more about how gluten affects the health of a person. The best way to avoid diseases for a gluten sensitive patient is to be on gluten – free diet. The negative effects of gluten in food Many researchers and physicians have been pondering lately over the considerable rise of diseases like obesity, osteoporosis, depression, celiac disease and non-celiac related food allergies among common people. There is much discussion ongoing in the medical world as to the major cause of such chronic diseases. Gluten is thought to be one factor which is recognized to be causing these diseases in people who are allergic to it. Research suggests the negative effects of gluten in food are obesity, osteoporosis, depression, celiac disease and non-celiac related food allergies. Gluten causes damage to the small intestine and start giving off symptoms in people who are gluten sensitive. The damaged intestine give way to inadequate absorption of nutrition and the gluten sensitive person suffers from different diseases. Gluten is a form of protein which is generally found in wheat, barley and rye. It can be said that, it is found in many types of cereals and various types of breads. However, gluten is not present in all types of food from grain family. Some grains like rice, millet, corn quinoa and oats do not contain gluten. Hunter (1987) states that “One of the gluten’s main protein fractions is gliadin, which is a complex mixture”(pg. 3). Books(2005)explains that “Gluten is a type of protein found in wheat, barley, rye, triticale and oats”(pg.7). When this protein is metabolized in the body of a certain person, it can at times give tremendous problem. In short, the body perceives this protein as a toxic and, introduces an attack against it. The symptoms in a person, depends upon the tissues of body that are attacked. Diet always has a significant influence on our health and it is well said that, we are what we eat. Scientist continues to discover new minerals, vitamins and herbal nutrients year after year. So it is not an amazing fact that, we are only realizing now, how gluten can affect our health. While exploring the ill effects of the gluten, it is discovered that gluten has a tendency to create an addiction among the people. It is found that grains which contain gluten create digestive stress to our bodies It is a thing to be noted that after the introduction of refined flours, diseases like diabetes, hypertension, gall bladder disease and colitis began to appear. Gluten itself contains two forms of protein namely gliadin and glutenin Lapid (2009) states that “Gliadin belongs to a family of proteins, called prolamins, that are found in the cereal grains. Gliadin prolamins are among the components of the gluten protein in wheat”(pg.29). Gliadin is the protein which creates digestive problems in human body. Gliadin contains amino acids and other chemicals which cause body a problem in the digestion. It has also been scientifically proven that individuals with certain genetics are more prone to gluten sensitivity. The reason why gluten’s effect was left unnoticed was because it set off indirect effect through our body’s own immune system. Cembrowicz & Allain (2007) writes that “Gluten intolerance also called ceoliac disease,causes damage to the intestinal lining which leads to malabsorption of many nutrients, including calcium and vitamin D”. Some terrible diseases caused by gluten can be classified as obesity, osteoporosis, depression, celiac disease and non celiac related food allergies. Let us have in-depth look into the cause and effect of gluten in relation with these diseases. Obesity In his book Gumbiner (2001) suggest that “Obesity is the condition of having an abnormally high proportion of fat …a complex multifactorial chronic disease that develop from an interaction of genotype and the environment”(pg.9). Generally factors which contribute to obesity can be age, sex and genetic structure of a person. It can be seen that most obese people have a genetic predisposition but eating pattern can also cause obesity to an extent. When an individual is twenty percent over weight than their ideal weight then he is considered obese. Gluten is highly related to causing obesity among people who consume it in excessive quantity. Especially, consumption of food with excessive content of carbohydrate like bread, pasta, cakes biscuits etc accelerates the obesity factor. Cerier (2010) in his book writes that “Gluten can even wreak havoc on thyroid function and may be a factor in the twin epidemics of diabetes and obesity”(pg.14).It is found that protein in gluten can create an addictive situation in the people consuming it, same like nicotin. These addictive substances are called “exorphins” and can highly contribute towards weight gain in a person. The exorphins suggest the person t o consume gluten contained products excessively, which, in turn, create mental disturbance and eating disorders among the person. When there is excess calorie intake the person naturally become subjected to obesity. It is noticed that once the person is on a gluten- free diet, they tend to lose weight. According to Ewell(2010)“Eating fewer gluten-free baked goods, fewer starchy carbs, and more whole foods overall helps keep insulin levels under control”. This in turn keeps the insulin normal and brings back the health of the patients. Family history of gluten sensitivity has a great role to play in causing obesity among people .The only real solution to gluten sensitivity and weight gain is to avoid gluten completely from the diet. Celiac disease Gluten is a very nutritious part of food, but it is proven that gluten can trigger several diseases to certain people who are sensitive to it. Celiac disease is one of a dangerous disease which occurs in people who consume excess gluten laden products. It is a disease in which the digestive system is damaged to an extent where it cannot absorb nutrients from food. According to Franklin (1997)“Celiac disease is characterized by small intestinal damage with loss of absorptive villi and hyperplasia of the crypts, typically leading to malabsorption” (p. 797 – 801 ) . People who are diagnosed with celiac disease are very sensitive to gluten. Gluten is said to be found not only in food but also in products like vitamins, lip balms and medicines. The immune system of people suffering celiac disease responds different to gluten than normal people. Once these patients consumes gluten, their immune system react by damaging villi- the small, finger like protruding element that lies in the small intestine. Villi, normally assist in the absorption of nutrients from the food. But in the case of celiac disease the patient become mal nourished despite excess consumption of food. Adams states that (1996) “Symptoms of celiac disease can range from the classic features, such as diarrhea, weight loss, and malnutrition, to latent symptoms such as isolated nutrient deficiencies but no gastrointestinal symptoms”. This disease is most commonly found in people of European descent, but recently cases o f this disease is also showing up among other ethnic groups. The symptoms of the disease appear to be different from person to person. It can show up in digestive system or in any part of the patient’s body. In infants and young children the symptoms commonly appear in the digestive system .According to Liebman(2002) “The symptoms of celiac disease in children typically become apparent three to five months after first consuming gluten- containing foods although for some few cases, the interval may be as short as one month”. The symptom usually observed is chronic diarrhea, vomiting, constipation, abdominal bloating, weigh loss and so on. Among common children a symptom of irritability is also found to exist. Since childhood requires appropriate nutrition for the healthy growth, malnutrition due to this disease can cause delayed growth, dental defects, delayed puberty a d short stature among young children. The symptoms among adults are distinctive from that of young children. Adults hardly show any signs of digestive problem, instead they have symptoms like iron deficiency, fatigue, arthritis, seizure, depression etc. Researches are underway to find out the reason why the disease affects people differently. The symptom of this disease also varies according to the age and the intensity of damage done to the small intestine. The symptoms some times appear in a person at a very late stage. If the disease is left undiagnosed and untreated, there are high chances that it can develop in to a complicated situation. Crangle (2006) claims that “One certainly can live well with Celiac Disease and, in fact, many of the popular diets followed by Americans today are actually severely gluten-restricted or gluten-free”(pg.13).This shows that the disease can be controlled if individuals become little cautious with their food habit. Osteoporosis Another condition caused by gluten intolerance is osteoporosis, where in the bone mass of the individual is greatly destroyed. The drastic malabsorption of calcium leads to loss of bone mass .When the loss of bone mass reaches a certain level, the individual get diagnosed with osteoporosis Osteoporosis can develop without pain until a bone breaks. These fractures of bone typically occur in areas like spine, wrist and hips .It can be affected by any bone, but usually hip and spine bone structures are affected. Meunier (1998) informs that “Hip fracture is the most serious complication of osteoporosis and is associated with considerable morbidity and mortality”(pg 4). This condition requires immediate hospitalization and surgery. Once affected by fractures, person become unable to walk independently and may even face with permanent disability or death. Recent studies show that body’s intolerance for gluten can lead to osteoporosis. The main reason how gluten causes osteoporosis is from chronic GI malabsorption as a result of continuous inflammation due to undigested gluten particles. Both inflammation in bowel and celiac disease can affect the bone health. Celiac disease is caused by the intestine’s sensitivity to gluten, which runs in the families. When the body cannot absorb the nutrients and calcium efficiently there can be negative effect on the body and result in osteoporosis. Women suffering from osteoporosis have a higher chance to have gluten allergies and even extreme form of celiac disease. According to (Ackerley) “In a recent study it was found that in eight patients who maintained a gluten free diet for a year six significantly improved their bone densities. This was also true for children with Celiac Disease where a gluten free diet quickly reversed low bone density”. So women have to be more cautious and should be alert as to their sensitivity towards gluten. An immense loss of calcium as a result of malabsorption can cause irreversible damage to them if left unnoticed. Any person with unrecognized osteoporosis is found to have unrecognized celiac disease. This condition cannot be detected with simple blood test. Kandoi(2005) writes that “The diagnosis can be confirmed by intestinal tissue biopsy or antibody test”(pg. 83).A lifestyle with gluten –free diet is the best solution for a healthy living. Along with it a supplementation of calcium and vitamin D should also be followed. A regular exercise will also help one to build new bone mass. Depression Depression being a mental illness is not necessarily considered as a medical condition like diabetes or blood pressure, regardless people affected by this disease are millions. It is generally seen that people with gluten sensitivity are immensely affected by mental disorder called depression. Nordqvist (2004) states that “Depression is not uniform. Signs and symptoms may be experienced by some sufferers and not by others. How severe the symptoms are, and how long they last depends on the individual person and his illness”. The reason behind gluten causing depression lie behind the process of malabsorption of necessary vitamins, minerals and amino acids from the diet, immune inflammation of brain tissue or both process simultaneously. It has been consistently revealed that people with depression had sensitivity to gluten. The primary system affected by gluten is digestive system and the second is nervous system. There depression causing agent is the protein gliadin in gluten. The depression is triggered when there is confusion in the immune system about the protein gliadin. Interesting fact is that, the protein gliadin is similar in structure to other proteins present in the body like the brain and nerve cells. According to Peterson (2009) “A cross reactivity can occur whereby the immune system “confuses” proteins in the body for the protein gliadin. This is called cellular mimicry and the result is the body attacking its own tissues with inflammation resulting. When inflammation happens in the brain and nervous system, a variety of symptoms can occur, including depression”. Since malabsorption is a condition in gluten intolerance, it can cause a substantial deficiency in protein in the body. Especially the amino acid tryptophan can be insufficient in the body of a gluten sensitive person. Trytophan is a protein in the brain which gives the feeling of relaxation and well being. A deficiency in this protein can be related to the depressive mode of a person. Clinic depression is connected to the serotonin levels in the brain and, ninety percent production of this chemical happens in the digestive tract. So it is an understood fact that food has a direct impact on the production of serotonin. So when there is an incomplete digestion due to gluten sensitivity it leads to defect in the production of serotonin. Ultimately the individual becomes victim of depression. Fassano (2010)“It is possible for depression to be the only symptom of gluten sensitivity or celiac disease, and it often improves remarkably once gluten is eliminated from the diet”. Non celiac related food allergy Allergies affect millions of people around the globe and they are mostly directly related to food. The people with gluten sensitivity also suffer from food allergies which are non related to celiac disease. The symptoms are difficult to differentiate as they are almost similar in nature. Wangen(2010) “Many people find that they cannot tolerate gluten, but they do not test positive on any of the tests used to diagnose celiac disease”. When blood tests are conducted, these symptoms shows negative result for celiac disease and this is when the doctor realizes it is allergy related to gluten intolerance. The only method to diagnose this condition is by the means of gluten free diet. In case of this kind of allergy a person might suffer from diarrhea and abdominal cramping.The patients with non-celiac gluten intolerance has the same kind symptoms like that of gastrointestinal problem. Many digestive disorders can show symptoms like that of food allergies. The person may not have celiac disease, but the experience can be the reactions of the presence of gluten in the food consumed. This food allergy can cause many difficulties in the patients. It can affect many areas of the body and cause discomfort to victim. Gislason(2004)“Immune responses to gluten can cause an alarming range of systemic diseases”(pg.10)The person can have indigestion, bloating, nausea vomiting etc. Sometimes fever, fatigue, sweating and chills can appear in the body. It can also affect lungs and as a result the individual can suffer from asthma, shortness of breath, sneezing and bronchitis. Muscles and connective tissue of the body are also affected in many cases. There can also be symptoms like pain and stiffness in the joints. Skin rashes and itching are also another symptom of food allergy caused by gluten intolerance. Unfortunately, the non celiac food allergy symptoms are poorly diagnosed and most patient misses out on many drugs and treatment .The elderly people are the one who suffer the most which such allergies as the condition worsens as age increase. However the sufferer can get back to normal health after the elimination of gluten from the diet. Tessmer(2003)“Once on a gluten -free diet , symptoms will diminish and the small intestines will heal and return to normal. Thereafter the person gain back his health and can lead a normal life”(Pg.16) Conclusion The subject of gluten intolerance is still a matter of great research. One theory claims that gluten intolerance is due to one enzyme deficiency in intestine, a genetic metabolic defect. Lack of this enzyme result in an incomplete synthesize of gluten protein. Usually the procedure is that gluten break downs and detoxify before it damages intestinal villi. Gluten intolerance may appear at any age. It is an old disease but only its designation is new to world. In many people the body reacts to gluten as if it is a virus and attacks its surrounding tissue violently. This damage done to the surrounding tissue can cause various health problems. Murray(2010) “The time when a patient develops symptoms varies from patient to patient after their first contact with the gluten protein”.Gluten’s side affects is just not creating diseases but encourage multi organ and multi symptom diseases. Braly(2002)“Fortunately the development of highly accurate blood tests for gluten sensitivity had made diagnosis much easier and facilitated research”.(pg.13) Tests like intestine biopsy are also used nowadays to confirm the celiac disease in gluten sensitive people. However, gluten sensitivity can be observed in the form of extreme celiac disease to sub clinical sensitivity. As gliadin is the root cause of all the problems, testing for antigliadin– antibodies in saliva is believed to be effective. Another method is to discontinue the consumption of gluten fro several days. Then resume consumption with a slice of cake or freshly baked bread. If the person feel discomfort in the form of bloating or fatigue it is most likely that he is suffering from gluten sensitivity. Anyway it would be very beneficial if the people are more educated about the negative effects of gluten on our body and given a chance for prevention of the diseases. Bibliography Adams, S. (1996).A Summary of celiac disease and gluten intolerance. Retrieved August 11, 2010, from http://www.celiac.com/articles/572/1/A-Summary-of-Celiac-Disease-and-Gluten-Intolerance-by-Scott-Adams/Page1.html This article is written by Scott Adams who was himself diagnosed with celiac disease. The diagnosis of the disease led him to research more about it and paved way to the creation of a website about celiac disease alone. In this article the writer attempts to point out the peculiarity of the symptoms of celiac disease. The website has describes very deeply about the disease and its cause and symptoms. He also describes various symptoms of celiac disease and depicts the seriousness of the disease. It was very crucial in the research to show the signs and symptoms of the disease and also it’s after affects. The article gives a good guide to people about the disease so that they can take preventive actions. He guides the people to take effective steps in order to prevent these abnormal health conditions. Since the research demand an in depth explanation about the sufferings about celiac patients, this source helped greatly (Adams 1996). Ackerley, M. (2010). Far reaching effects of gluten sensitivity. Retrieved August 11, 2010, from http://www.mypassion4health.com/articles/gluten_sensitivity.html. Ackerley, is a physician with MD and is a psychiatrist. She also specialized in hormonal replacement treatment and weigh loss problems. She shows here the result of the research conducted on a group of people regarding the gluten and bone loss. The research reveals that a gluten free diet can have a reverse effect on gluten sensitive people regarding their low bone mass density. The source explains that osteoporosis is caused by malnutrition and if the patient is put on a gluten free diet they can get relieved from osteoporosis and attain greater bone density. The source give a very in depth insight about the effects of gluten sensitivity. The website my passion 4 health is very informative and is mainly focused on describing the topic of health .It is been written by physicians and health experts and guide people to combat various health conditions and also suggest healthy living(Ackerley 2010). Books, M. (2005). Eat well live well ... with gluten intolerance. London: Murdoch Books Uk Ltd.. The author here points out the grains that contain gluten .This is very essential point as it gives the reader an idea about the source of gluten. He states that wheat, rye, and oats etc are grains which contain gluten and also reveals that gluten is the protein contained in them. Since the research is about gluten the origin of gluten is very essential to be discussed and the source has come to a great help .This source is a well written book by Mr. Books in which the aspect of gluten intolerance is described. The author has formed guidance to the people with gluten intolerance to live a health life. The book has been written to guide the people who need to follow a gluten- free diet. It gives practical advice about gluten, celiac disease and other ill effects of gluten. The book also helps the gluten sensitive people by offering great advice how to avoid negative effects of gluten (Books 2005). Braly, J., & Hoggan, R. (2002). ). Dangerous grains: why gluten cereal grains may be hazardous to your health .. U.S.A.: Penguin Putnam Inc. The authors in this source explain that there is blood test available to diagnose gluten sensitivity which is a great blessing for people suffering from gluten related problems. This has facilitated much in preventing the problem if the person recognizes that he is suffering illness after consumption of gluten based food. The authors both who have written the book are gluten sensitive and have made a valuable contribution and guide to other people around the globe who are suffering from the same disease. Both the authors have done adequate research and have explained the impact of grains on range of diseases like cancer, autoimmune disease, osteoporosis and intestinal disease and many others. This book help the reader to understand how the grains can affect their health and whether they are at risk from gluten related illneses.Mr.Braly is an expert in food allergy and physician with M.D,and Mr. Hoggan is a respected lecture and researcher in gluten illnesses.(Braly& Hoggan 2002) Cerier, L. (2010). Gluten-free recipes for the conscious cook. California: New Harbinger Publication Inc. The author here talks about how the gluten becomes a reason for the development of obesity and diabetes in a gluten intolerant person. The source clearly mentions that gluten has the ability to disrupt the functioning of the thyroid gland in a person’s body. This malfunction can lead to obesity and diabetes in individuals. Since obesity is one of the results of gluten intolerance, the statement by author clarifies the possible reason for obesity. The book is a cooking guidance for gluten intolerant people and gives vast information to the readers about choices of gluten free food. The author is a well versed writer and has written numerous amounts of books .She is a national authority on gluten free cooking and has provided a great help to people with gluten sensitivity world wide. The author has taken help and assistance from doctors and dietician to provide valuable information to people with gluten sensitivity(Cerier 2010). Crangle, C. (2006). Living well with celiac disease: abundance beyond wheat and gluten. Victoria B.C.: Your Health Press. The author here states that, if a celiac patient follows a gluten free diet, he/she can be successful in leading a healthy life. The description of celiac disease was a very crucial aspect of the research and the valuable information in the book has been a big support. The writer here pin points that there are numerous Americans who are following gluten free diet to get relief form the side effects of gluten. The author being a celiac patient herself has made a major attempt to help people around the globe in understanding more about the disease. She has also given good information about the disease along with a food guide with gluten free food products. The author has taken a good support from doctors, celiac disease foundation and gluten intolerance group of America. Finally it can be said that book has been a great resource of gluten free diet and celiac disease information(Crangle 2006) Cembrowicz, S.,& Allain, T . (2007). Osteoporosis. London: Class Publishing (London) Ltd. The authors here suggest that the gluten intolerance is also called coeliac disease .They give insight to the readers that how gluten create defect in the digestive system of the people with gluten sensitivity by damaging their intestinal lining. This book written by them is explaining the topic of osteoporosis in detail, where they claim that gluten also can cause osteoporosis. They have explained that malabsorption due to defective intestinal functioning can cause deficiency in calcium and vitamin D. This cause weak bone mass and cause osteoporosis. Moreover the authors tries maximum to give a positive hope to the diseased to lead a healthy life. The authors being doctors have given good justification to the writing and helped in understanding the disease in a better way. The authors have in a way helped the gluten intolerant people to take action against the development of osteoporosis. This source is very credible as it is written by physician well versed in the subject. Ewell, Vickie. (2010). Weight gain from gluten free diet meals – eat to lose weight. Retrieved from http://autoimmunedisease.suite101.com/article.cfm/weight-gain-from-gluten-free-diet-meals--eat-to-lose-weight The source is from an online magazine which publishes very credible article about health and medical field. It has access of well versed writers across the globe who is physicians, dieticians and medical experts. The website is owned by a private Canadian company based in Vancouver, British Columbia and has offices in Berlin, Madrid, and Paris. The author here has warned the readers who are gluten sensitive to refrain from eating wheat products which have excess gluten content. She states that if the gluten in the food is less then the insulin level of the body can be controlled. This action also helps in reducing the weight of the gluten intolerant people who are obese. The writer in the article has taken great effort in elaborating ways to the gluten sensitive people to regulate their diet. She has explained the reason for gluten sensitivity and weight gain problems related to it and ways to avoid it(Ewell 2010) Fassano, A. (2010). Depression, anxiety, panic. Retrieved from http://sites.google.com/site/jccglutenfree/depression,anxiety,panic The source is a gluten file and it explains about all the disease caused by the gluten .Here it is stated the depression might be caused only because of gluten. The article is suggesting the depression and other psychotic illness can be because of the negative effect of gluten. The author says that the depression has been proved to be disappearing in a patient with a gluten – free diet. So in order to prevent depression it is best for the individuals to recognize their sensitivity to gluten and refrain from gluten based food products. The article also describes about other diseases caused by gluten and suggests preventive measures to be taken .The source has come up with a genuine argument that only cause of depression can be gluten. Since cause of depression is not recognized the author could be right in claiming so. The writer of this article is a pediatric gastroenterologist at the University of Maryland School Medicine (Fassano 2010). Franklin, K.B. (1997). Identification of tissue transglutaminase as the autoantigen of celiac disease. Nature Medicine, (3), 797 – 801 This source is from an academic journal and it is about celiac disease and how this disease develops among the people with gluten sensitivity. It is stated by the writer that a part of the intestine is damaged while synthesizing gluten by the body. A part of intestinal lining called villi damages and the patient fall victim to malnourishment. This makes the person sick and fall prey to various other diseases. The reason for the cause of celiac disease is very important and the source helps in identifying the real reason behind this disease. The source give insight to the minute detail which cause damage to the body and give way to complication to celiac patients. This article is a very credible source as it is extracted from a highly known academic journal Nature Medicine. The important article in this journal is used in the research to understand more about celiac disease (Franklin 1997). Gumbiner, B. (2001). Obesity. U.S.A.: Versa press. The author discuss in this book about obesity and various factors contributing to obesity. He shows that the excess accumulation of fat in the body lead to weight gain and obesity. Since obesity was a major consequence of the gluten sensitive issue, it was very mandatory for the explanation of this subject. The author in this source has given a precise and accurate description about the term obesity which is very satisfactory. He explains that other factors like gene and environment also has certain influence in making a person obese. This book is written by Gumbiner , who is a physician with MD. He is well versed in the subject of weight loss and other problem related to it. The book is a product of American College of Physicians and has immense information about obesity. The book has wide information about every aspect of obesity, which has become very useful for the explanation of the subject of obesity in the research (Gumbiner 2001). Gislason, S.J. (2004). The Book of gluten . Canada: Enviromed Research Inc.. The source is a book which solely describe about gluten and its effect on human body. It could be also said that every one who suffer from gluten intolerance should definitely read this book.Thebook has given wide description about the grains that contain gluten .It has exclusively described about the celiac disease and other gluten related diseases. The author here has stated that gluten can trigger various symptoms in the people with gluten sensitivity. Basically the immune system of such a person can get very negative responses and he can be subjected to various diseases. The author explains that the range of diseases can be at alarming rate. This supports the explanation on various symptoms found in gluten sensitive people. The writer of this book is a physician with M.D and has been a victim of gluten based food allergy. The source is perfect as it is an outcome of twenty years of research by writer(Gislason 2004). Hunter, B.T. (1987). Gluten Intolerance. U.S.A.: Keats Publishing Inc. This source is from the book Gluten Intolerance, which explains elaborately about gluten intolerance found in people. The author explains that because of the unique nature of the protein gliadin in the gluten, problems are created in gluten intolerant people. He states that gliadin has a complex structure and is difficult for the body to metabolize it. The statement by author is used here to show the complex nature of protein gluten and to support the fact of gluten sensitivity. With the help of this source it has been helpful to prove the nature of the protein gluten which is the main cause of negative effect in gluten based food. The author in this book has given extensive information about gluten intolerance in people. This book is a health book guide by the Keats publishing company. The information in the book is very credible as it is written by physician and also proves to be the right source for the research since it is about gluten intolerance (Hunter 1987). Kandoi, M.R. (2005). Clinical aspects in osteoporosis . New Delhi: Jaypee Brothers Medical Publishers Ltd.. The source has been of great help as it explains the methods by which the gluten intolerance can be detected in patients. It is not an easy task to recognize the disease in patients. The source assists in understanding the medical techniques to detect the celiac disease in people. Since gluten intolerance give way to numerous illnesses it is very important to diagnose this disease at earlier stage. The author states that intestinal biopsy and anti body tests are the only genuine way to detect the gluten intolerance. The book here explains about the clinical aspect of osteoporsis.Osteoporosis is one of the ailment caused by gluten and in order to prevent it an early diagnose by intestinal biopsy or anti body test is essential. This source is very credible as it gives every detailing about the topic osteoporosis as it is essential for the research work. The author is also well versed in the subject as he is a founder and president of Institute of Arthritis care(Kandoi 2005). Loftus, C.G., & Murray, J.A. (2010). Celiac disease. Retrieved from http://www.acg.gi.org/patients/gihealth/celiac.asp The author here states that the time when symptoms appear in patient varies depending on each person’s case. He claims that once the person has contact with gluten it can take some time to show the symptoms and this is not same for every person. Some may show bad signs early and for some it may take long duration. The source is a very credible one as it is a medical online journal which provides information written by well accredited physicians. The article has explained celiac disease in a very clinical way and also has given pictures and images showing the part of intestine which gets affected by gluten. The article writes about every aspect of celiac disease and mentions about all the diseases affected by gluten. This article is from the American college of gastroenterology and the authors are physicians with M.D. The writers are from Division of Gastroenterology and Hepatology has done full justice in explaining about celiac disease(Loftus &Murray 2010). Lapid, N. (2009). Celiac disease. Retrieved from http://celiacdisease. about.com /od/celiacdiseaseglossarygl/g/Gliadin.htm The author here makes it clear about the real cause of gluten sensitivity in human body. It gives a very minute detail as to the cause of gluten sensitivity. Author reveals that the component gliadin present in gluten is the real culprit for all the problems. He also tries to give a clear image to people about the gliadin which is present in gluten. This is explanation is very crucial for the research as it explains the root cause of gluten intolerance. The author of this source is a medical editor and also helps scientists and doctors in writing for research. The author is herself a celiac patient and with great effort has succeeded in thriving on a gluten free diet. She has written the article to help others who suffers like her from celiac disease. The source is very credible as she has given many speeches to medical students and written for well know medical centers and hospitals (Lapid 2009). Liebman, W.A. (2002). Celiac disease in children. Retrieved from http://www.e-celiacs.org/2-Celiac_Disease_in_Children.htm. The author here specifically mention about the symptoms occurring in children with gluten sensitivity. He points out the time when the symptoms of gluten sensitivity appear in children. Since the celiac disease description requires the more detailing about the disease such an explanation from the author has come to great help. The author in this article has very elaborately explained about the celiac disease in children. He has very professionally explained the various symptoms that have to be looked out for celiac disease. He has also given reasons why a particular child suffers from celiac disease. Moreover gluten – free diet guide is also provided to assist the patients. The following source is very valuable as it is a part of case study found in Pediatric Case Studies. It is published in New York by Medical Examination Publishing Co. The author is also a physician with M.D. and has attained graduation from University of California School of Medicine, San Francisco(Liebman 2002). Meunier, P.J. (1998). Osteoporosis: diagnosis and management . London: Martin Dunitz Ltd. The source has been very helpful in research as it explains critically about the ill effects of osteoporosis. This book is all about osteoporosis and its diagnosis and management. The author has taken a good effort to cover all aspects of the disease and gives very wholesome information to the reader. Since osteoporosis is a disease caused by the negative effect of gluten in food, its impact on health was very important to be discussed in the research. The author here states that hip is the most affected part during osteoporosis. It is claimed that this disease can cause fractures foremost in hip area and lead to disability and even death in patients. The author is a founding editor of Osteoporosis International, and has given good insight on osteoporosis with the help of an international team of experts. The book is used in the research to provide information about the disease osteoporosis (Meunier 1998). Nordqvist , C. (2004). What is Depression? what causes depression?. Retrieved August 11, 2010, from http://www.medicalnewstoday.com/articles/8933.php The author in this article states that people with depression does not always portray same signs or symptoms. Some people may not show symptoms at all. The symptoms may be different according to the situation and illness of the person too. Depression can occur in persons due to various reasons. As a result the intensity of the illness is also varying, some may have minor symptoms but some can even go to the extent of suicidal attempt. The author explains depression and its causes in this article very elaborately. He has put his maximum effort to cover all sides of the disease and present a well informed article. The website medical news today is a well known site which brings forth news about health and medicine from well known sources. They also provide information with the help of their own team of writers. The source has helped immensely in giving idea about depression and its causes (Nordqvist 2004). Peterson, V. (2009)Gluten sensitivity and depression. Retrieved August 11, 2010, from http://www.celiac.com/articles/21758/1/Gluten-Sensitivity-and-Depression/Page1.html This article is mainly about the ability of gluten in triggering depression among people with gluten intolerance. The research demands an explanation as to why gluten intolerant people suffer depression. This source gives a very good support to the fact of depression and its relation to gluten. The article specifies that gliadin is a protein very similar in nature to protein in brain and nerve cell. As a result body gets confused and attacks its own cells creating depression. This has helped greatly in convincing the gluten’s hand in creating depression and other mood swings in person with gluten intolerance. The author of this article is a renowned medical practitioner and chiropractor. She is also a certified clinical nutritionist and a director of a health centre. Her medical centre research in to various complicated health situations and diseases. As a result provide very knowledgeable information about depression and gluten sensitivity (Peterson 2009). Tessmer, K.A. (2003). Gluten-free for a healthy life. New Jersey: The Career Press. The author here explains that in order for the gluten sensitive person to regain health the best method is to follow a gluten free diet. It is more that once the gluten is avoided from food lists the all the symptoms showing in the patient would withdraw and he can gain back perfect health. The writes states that after stopping the consumption of gluten the small intestine heals and this is the reason why the person gains health back. The source has been very supportive in explaining how the people with gluten sensitive can live a normal healthy life. This book is a comprehensive resource which describes every aspect of celiac disease and gluten related problems. It also helps the readers in diagnosing the disease at earlier stage and also provides daily skills to survive this disease. The book contains invaluable advice from experts who have great experience with gluten related diseases and allergies ( Tessmer 2003). Wangen, S. (2010). Understanding non-celiac forms of gluten intolerance. Retrieved from http://www.wellsphere.com/healthy-living-article/understanding-non-celiac-forms-of-gluten-intolerance/1113780 This source is a very well know web platform where people gather to discuss about health related experience and to give medical guidance to people. It has mostly articles written by doctors and other experts in medical field. It has abundant information about health and fitness, tips to improve health and knowledge about diseases. Here in the article author gives information about the non celiac disease which shows symptoms very similar to celiac disease but in itself is a different condition. The author explains that when the patient with gluten intolerance symptoms tests for celiac disease they show negative results. This is because they are suffering from non celiac food allergy. It is very important for the individuals to differentiate the disease and get the appropriate treatment for the same. The writer of this article is a doctor and an expert in gluten free diets, food allergies, gluten intolerance and celiac diseases. He is based in Seattle, Washington and has been very helpful in guiding people around the globe (Wangen 2010). Read More