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Freeze-Drying Commenrial mannitol to use as Cartrier to Enhance Pulmonary Budesonide Via DPI - Literature review Example

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Dry Powder Inhaler (DPI) Formulation: Freeze-Drying Commercial Mannitol to Use as Carrier to Enhance Pulmonary Budesonide Delivery Via DPI By Student’s ID Number Module Title and Number Name of Professor/ Tutor Dry Powder Inhaler (DPI) Formulation: Freeze-Drying Commercial Mannitol to Use as Carrier to Enhance Pulmonary Budesonide Delivery Via DPI Introduction Dry powder inhalers (DPIs) are devices widely used for delivering drug formulations to treat various lung disorders including asthma and chronic obstructive pulmonary disease (COPD)…
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Freeze-Drying Commenrial mannitol to use as Cartrier to Enhance Pulmonary Budesonide Via DPI

Download file to see previous pages... This lack of drug delivery efficiency is caused by difficulties in powder dispersion leading to poor lung deposition and high dose variability (Daniher and Zhu, 2008). Lactose which is used as inert excipient in dry powder inhalers (DPI), is considered a less suitable excipient for the next generation of inhalable products such as proteins and peptides, due to its incompatibility with drugs distinguished by primary amine moieties. Consequently, “using alternative excipients appears to be an attractive option for DPI formulations” (Kaialy and Nokhodchi, 2012, p.3). Therefore, in the pharmaceutical industry, there is growing interest in replacing lactose with other excipients which facilitate greater efficiency of drug delivery through inhalation. The possible carriers or excipients for dry powder inhalation formulations are few, because they are required to fulfill particular conditions such as “being endogenous, able to be metabolized or cleared, and have no potential to injure or irritate the lungs” (Kaialy and Nokhodchi, 2012, p.2). ...
freeze drying technique retrieves dry product from aqeous solutions, and it is “commonly used for preparing injectable pharmaceutical products” (Kaialy and Nokhodchi, 2012, p.2). The purpose of this literature review is to investigate various elements related to dry powder inhaler (DPI) formulation properties, and the different parameters associated with the particle analysis of powder in dry powder inhaler formulation. Dry Powder Inhaler (DPI) Formulation Properties Best Drug Particle Characteristics for Dry Powder Inhaler (DPI) Formulation In dry powder inhaler formulation, one of the most important design requirements is the estimation of particle size (Daniher and Zhu, 2008; Park and Lee, 2000). Dry powder inhaler formulations are required to create an aerosol cloud of appropriately sized drug particles to avoid their deposition prior to reaching the site of their destination (Virchow, Crompton, Negro et al, 2008). Different geometric characteristics and physicochemical properties are examined by methods for determining the particle size distribution (PSD) of a formulation (Snow, Allen, Ennis et al, 1999). Flow rate of inhalation is associated with inhaler performance, and should be included in any comparative in vitro testing of DPI formulations (Pitchayajittipong, 2008). Internal resistance is an important component of every dry powder inhaler device, which determines the flow rate of inhalation achieved by a patient using the device. For successful development of DPI systems, it is essential to combine progress in two areas, device engineering and powder formulation engineering (Harris, 2007). Increasing therapeutic outcome through optimising drug delivery to the lung is important, and dependent to a large extent on aerodynamic diameter (Hinds, 1999), which ...Download file to see next pagesRead More
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