We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Nobody downloaded yet

Immunologic diagnosis of tuberculosis - Research Paper Example

Comments (0) Cite this document
The objective of this research is to acquire a better insight of the issue of TB vaccination. The research demonstrates a long history of search for a protective vaccine against tuberculosis and evaluates the problem of complications of BCG vaccination…
Download full paper
Immunologic diagnosis of tuberculosis
Read TextPreview

Extract of sample
Immunologic diagnosis of tuberculosis

Download file to see previous pages... From this research it is clear that all people have natural immunity to tuberculosis. The attempts to find a correlation between sensitivity to tuberculosis and HLA phenotype have produced conflicting results. Although sensitivity to tuberculosis is associated with race, the evidence is largely unconvincing. Age is an important determinant of natural resistance to tuberculosis. Although there is no specific data concerning the relationship of nutritional status and immunity against tuberculosis, it is clear that malnutrition and tuberculosis are related in some way. Primary tuberculous infection is associated with the development of acquired immunity. Tuberculosis which is caused by exogenous reinfection in North America and Europe are rare. Much more often it is registered among the population with a high incidence of tuberculosis, where there is a high risk of reinfection. It would be appropriate to note that the immune system in the classic sense of the word means resistance to infection, whereas hypersensitive means a state of the damaged host's reactivity. In this sense, immunity may be the result of infection caused by other mycobacteria, or the result of vaccination of bacillus Calmette-Guerin (BCG), or the result of natural infection with mycobacteria, which common in the environment. This acquired non-specific immunity can be regarded as a reflection of the primary activation of macrophages. (Chan, 2000, 134) Topic 1. M Tuberculosis Antigen-specific immunity is mediated by T-lymphocytes and can be adapted by them. Antigen-specific immunity is strongly correlated with delayed-type hypersensitivity. It can act as an independent factor, but it is believed that functional expression of cellular hypersensitivity is the most efficient. Tuberculin sensitivity is antigen-specific in nature and develops after the primary infection. It is directed mainly against protein antigens. Mycobacterial antigens are the subject of diverse immunochemical studies. (Smith, 2005). It is quite clear that there is no single dominant antigen, and in any microorganism which is artificially infected or sensitized hypersensitivity to the set of mycobacterial proteins develops. Tuberculin purified protein derivative (PPD) is antigen preparation which is most often used in clinical and epidemiological practice in order to identify the tuberculin hypersensitivity and it is a mixture of crude largely denatured antigens and poorly reflects the character of the natural antigens. (Brennan, 2009, 335) In the case of infection in organism the protein antigen mycobacteria are always present in association with this set of adjuvants. In vitro studies have shown that the purified arabynogalactan is a potent immunosuppressive agent. (Chan, 2000, 134) The recognition of antigen which is sensitized by macro-processing is accompanied by macrophages and it depends on the expression of macrophages on their surface of antigen-specific epitopes associated with the Ia-antigen gene product of histocompatibility. This complex is recognized by specific T lymphocytes. For the development of the response of T lymphocytes to antigen presentation also requires macrophage synthesis and secretion of interleukin-1. (Chan, 2000, 137) The immunoreactive cells secrete mediators that can cause activation of macrophages. The macrophages as the main effectors cells of tuberculin hypersensitivity. The peripheral blood monocytes of TB patients have some properties which are the characteristic of activated macrophages, including enhanced activity against hecsomonophosphatus, increased ability to to the surface adhesion, expression of specific membrane structures and increased bactericidal activity. However in some cases of tuberculosis it is possible to observe the deviation from the state of hypersensivity (Chan, 2000, 137). Such cases formed the basis for the assumption that TB can develop in the presence of immunological spectrum in the ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Immunologic diagnosis of tuberculosis Research Paper”, n.d.)
Retrieved de https://studentshare.org/health-sciences-medicine/1391162-tuberculosis
(Immunologic Diagnosis of Tuberculosis Research Paper)
“Immunologic Diagnosis of Tuberculosis Research Paper”, n.d. https://studentshare.org/health-sciences-medicine/1391162-tuberculosis.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Strategic Diagnosis Project
This search engine developed called ‘BackRub’ was finally transformed into Google in 1998. Strategically the company works on gaining a large web space through the operation of the search engine which helps the visitor to gain access to large amount of information pertaining to different types of products and services.
10 Pages(2500 words)Research Paper
Solar Powered Field Kit for the Diagnosis of Tuberculosis
Much of this population is in remote locations in Africa and South America. Current methodologies for the diagnosis of TB rely on labor intensive and delayed laboratory analysis of blood samples. A field kit is needed to diagnose patients in these remote locales that does not rely on extensive laboratory analysis and the utility of electrical power.
5 Pages(1250 words)Research Paper
PC Maintenance, Troubleshooting and Diagnosis
The need for efficient, accurate, dependable, well organized and time saving work is the raison d'etre of computers, and PCs have invariably taken their place comfortably in contemporary life, for a day without it, and we would be complaining about how the day has been very tiresome and frustrating, detaching us from the rest of the world by restricting communication to the rest of the world through social networking and other media.
7 Pages(1750 words)Research Paper
Diagnosis and Treatment Recommendations
With respect to the case study report, the male client in subject named Blackwell is experiencing a substance abuse related problem in his life. He is a separated father with three children, who are currently living with their mother. The reason for separation derives its roots from Blackwell’s habitual substance abuse problem within the household setting.
5 Pages(1250 words)Research Paper
Is there an association between Chronic obstructive Pulmonary disease and acquisition of Pulmonary Tuberculosis
Reports bared that there are already millions of people affected by COPD, though not transmissible but some of them are infected with this disease without medical knowledge on it and thus bereft with knowledge on how to go about with this disease for medication.
5 Pages(1250 words)Research Paper
It can spread from one person to another through different ways, but generally air happens to be the prominent method for the spread of Tuberculosis. The germs of TB known as bacilli, enters into air, when a TB patient sneezes, talks or spits. This way the germs can enter into another healthy person's body during inhalation.
4 Pages(1000 words)Essay
Tuberculosis within Immigrants
The research objective was to define the patterns and frequency of incidence. This would assist in Tuberculosis Policy forming and attempt at curbing the spread of the disease, bringing the country at par with standards established by other industrialized countries.
3 Pages(750 words)Research Paper
Pre-implantation genetic diagnosis (PGD)
This allows doctors to then check the genes in the embryo that has been generated in order to ensure that such a genetic condition is not present. This test tasks place
30 Pages(7500 words)Research Paper
One can stay with the T.B bacteria for a long time in the body without developing the symptoms of the disease provided that they have strong humane system. However groups such as people with HIV or elderly adults the TB bacteria can become active. In their
8 Pages(2000 words)Research Paper
Molecular diagnosis of Neonatal mellitus

In this research study, the use of whole exome sequencing for patients with NDM provides a pertinent substitute for NDM molecular diagnosis.  Initially, patients who suffered from diabetes mellitus were treated using insulin therapy. Patients who carried a mutant gene in KCNJ11 or ABCC8 were treated using oral sulfonylurea drugs instead of insulin.

6 Pages(1500 words)Research Paper
Let us find you another Research Paper on topic Immunologic diagnosis of tuberculosis for FREE!
Contact us:
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us