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Good Cholesterol and Breast Cancer risk - Essay Example

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Gender, Science and Technology Primary science article and Popular article – Summaries The primary science article, Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development, written by Christiane Danilo, Jorge L Gutierrez-Pajares, Maria Antonietta Mainieri, Isabelle Mercier, Michael P Lisanti and Philippe G Frank, explains the role of Scavenger receptor Class B Type I (SR-BI) in breast cancer development…
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Good Cholesterol and Breast Cancer risk
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Download file to see previous pages This phenomenon reduces the risk of heart diseases but at the same time HDL also stimulates migration and activates signal transduction pathways in the human breast cancer cell lines, thus acting like a catalyst in the development of breast cancer. Thus knocking down the HDL receptor, SR-BI by some pharmacological methodologies play an essential role in regulating cellular proliferation and migration, thus controlling the growth of tumor cells, and hence SR-BI can be essentially used in the treatment of breast cancer in humans. The Popular article, Good cholesterol and breast cancer risk explains about the above detailed primary research article in a crisp manner. Though HDL that is, good cholesterol is good for health and acts like a protective shield against heart disorders, it has a negative impact on breast cancer development in humans. Higher the level of HDL in blood, higher is the risk of developing breast cancer. Thus limiting the HDL receptor, SR-BI the rapid proliferation of tumor cells were found to be greatly reduced. The popular article also interacts with Dr. Philippe Frank, head of the research team and a cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University who stresses on the importance of inventing more specific drugs to inhibit SR- BI and the safer level of HDL to be mentioned in cancer patients. How it relates to the theme – ‘Gender, Science and Technology’ Both the articles are interlinked and have a strong correlation with the theme of ‘Gender, Science and Technology’. The main focus of both the articles is about the treatment for breast cancer. Though the exact cause for breast cancer is still a topic under research, analysing the risk factors can show who is most likely to develop the disease. Lifestyle choices, genetic disorders and medications taken for some kind of diseases may be some of the risk factors for developing the disease but some risk factors are more vulnerable, particularly one’s ‘Gender’. Breast cancer is most common in women because they have more breast tissue than men. Breast cancer causes include what stimulates the breast tissue to grow and develop. Female relatives can also be a risk factor for getting breast cancer. If one’s mother, sister or daughter have breast cancer, the chances of getting the disease is doubled. Though cancer of several types is the leading cause of death in the world, medical science and technology has empowered people to make life changing decisions by matching them with modern and advanced treatment options based on individual conditions of the patients. Modern science and technology has revolutionized the breast cancer research therapies and now chances of overcoming breast cancer are much better than in earlier days. Main Scientific Claim The authors claim that their examination about the role of HDL and SR-BI in the regulation of cellular signalling pathways in breast cancer cell lines and development of tumors show that, HDL can stimulate the signal transduction pathways in the human breast cancer cell lines. Then, accelerate the formation of tumors and hence knocking down of HDL receptor, SR-BI limits the ...Download file to see next pagesRead More
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