Correcting Sickle Cell Disease using Stem Cells
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... cell anemia is a hereditary disease caused by the expression of hemoglobin S gene rather than that of hemoglobin A, producing crescent red blood cells (RBCs) instead of the normal concave RBCs. The abnormal shape prevents the proper transport of oxygen from the lungs to the other tissues of the body, and causes the RBCs to clump together, and clog the blood vessels. The disease manifests after 4 months of age, and its symptoms include painful episodes that last from hours to days, breathlessness, delayed growth, fatigue, fever, rapid heart rate, ulcers, jaundice, thirst, urination, priapism, and blindness (Zieve and Chen, 2011).
The pattern of inheritance of sickle cell anemia is autosomal recessiv...