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Increase of the Reduced Glutathione Level in Kidneys of Old Rats - Research Paper Example

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The author of this research paper "Increase of the Reduced Glutathione Level in Kidneys of Old Rats" aims at investigating the possible reduction in Glutathione level (GSH) in kidneys of old rats after being treated with Diallyl Trisulfide (DATs) contained in Garlic. …
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Increase of the Reduced Glutathione Level in Kidneys of Old Rats
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Download file to see previous pages From the beginning of civilization, plants have formed a fundamental part of the society of humans. In most cultures, garlic (Allium sativum L.) is widely used as the condiment and as a spice in many dishes. A number of cultures use garlic as a medicine. There are also numerous publications concerning the pharmacological characteristics of garlic including their benefits on health (Rahman, 2007; Kojuri et al., 2007). Garlic is used as a medicinal herb and as a spice. Majority of the recent researches on garlic have utilized garlic in various forms such as tablets, raw, flesh, dried, boiled, and cooked (Gorinstein et al., 2006). Commercially, garlic is available in form of garlic powder, garlic oil, and pills and is widely used for therapeutic purposes (Elkayam et al., 2003).
Garlic contains sulfuric and non-sulfuric compounds. Many studies focus on the benefit of the oil-soluble sulfuric compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide, allyl methyl trisulfide, dithiins, and ajoene. Some other research focuses on the water-soluble sulfuric compounds such as S-allyl cysteine (SAC), S-allyl mercaptocysteine (SAMC) and S-methyl cysteine, and gamma-glutamylcysteine derivatives (Velmurugan, Subapriya, Nagini, 2003).
Organosulfur compounds in garlic have been found to contain antioxidant properties. A study showed that the use of garlic oil supplements by hypertensive adults decreased a biomarker of in vivo fat oxidation in a controlled trial (Falcioni, et al., 2010). However, it is not clear yet whether organosulfur compounds in garlic exhibit antioxidant effects in vivo. GSH is the key regulator of cell proliferation, metabolism, pathways, cell signal transmission into the nucleus (Pallardo, 2009). Moreover, its nuclear concentration is the most important player in preventing oxidation (Kulinskii, 2010). ...Download file to see next pagesRead More
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