Nobody downloaded yet

Investigating the molecular basis of oligomerisation specificity using coiled coil peptides - Essay Example

Comments (0) Cite this document
Currently, coiled coils are successfully and extensively used in the designing of multi-stranded structures that are applied in biotechnology, basic research, nanotechnology, and medicine and material science. The broad application range and the critical functions played by…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER97.2% of users find it useful
Investigating the molecular basis of oligomerisation specificity using coiled coil peptides
Read TextPreview

Extract of sample
"Investigating the molecular basis of oligomerisation specificity using coiled coil peptides"

Download file to see previous pages The studies have identified that there is unexpected and general correlation between trigger sequences (Indispensable elements for coiled coil formation) and coiled coil oligomerization state specificity .Through the use yeast archytype coiled-coil domain transcriptional factor activator GCN4 as a model system, it was found that oligomerization state determinants that are trimer specific and well established ,switched the topology of the peptide to a trimer from a dimer, only after being inserted into the trigger sequence. The results were confirmed with 2 other coiled coil dimmers that is not related (cortexillin-1 and ATF1).It is further indicated that multiple topology determinants have the capacity of co-existing in the same trigger sequence, and this reveals a delicate balance of the resultant oligomerization state through forces that are position dependent (Steinmetz et al., 2007). Due to the simplicity of this leucine zipper, the alpha helical coiled coil has been traditionally used in a broad number of studies that have targeted the key principles of protein stability, oligomerization and folding (Steinmetz et al., 2007).In this case, the coiled coils currently are exploited as multipurpose tool in various applications seen to be increasing steadily as well as ranging from basic research to medicine.
It is well known that what is referred to as trigger sequence plays a critical role in controlling coiled –coil formation. The distinct feature of several trigger sequences is that they have a capacity of folding into several reasonable stable monomeric helices before the formation of the coiled coil structure (Kammerer et al.1998) Recently, the NMR structures of peptide spanning the GCN4 trigger sequence was solved and indicated that the structure is stabilized by electrostatic interactions and a network of hydrogen bonds (Steinmetz et al., 2007)
The trigger ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Investigating the molecular basis of oligomerisation specificity using Essay”, n.d.)
Investigating the molecular basis of oligomerisation specificity using Essay. Retrieved from
(Investigating the Molecular Basis of Oligomerisation Specificity Using Essay)
Investigating the Molecular Basis of Oligomerisation Specificity Using Essay.
“Investigating the Molecular Basis of Oligomerisation Specificity Using Essay”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Molecular basis of aging in relation to fertility
With regards to the molecular aspects of aging, it is usually characterized by the accumulation of defective or inactivated forms of various enzymes, possibly due to oxidative damage by agents such as free radicals (Stadtman 131). A certain group of protein regulators that control enzymatic products called the polycomb group (PcG) control various gene loci that are essential to an organism, and one of these loci is the Ink4a locus, which contains genes responsible for senescence in organisms (Mishra and Mishra 135).
3 Pages(750 words)Essay
Please read the cases and answer the questions by using the relevant legal basis
Thus venturing into the region without following proper legal channels would jeopardize the functionality of the business. To enter a new
1 Pages(250 words)Essay
Specificity and Sensitivity
However, Tappen (2011) further noted that these tests are dependent on the limiting value above or below which the test indicates positives results. According to Lovallo et al (2010),
1 Pages(250 words)Essay
Molecular biology
idences of treatment failures have been reported for this disease, causing rising concern to health care providers and researchers (Blomquist, et al., 2014). The causal organism Neisseria gonorrhoeae has been reported to exhibit resistance to first line therapeutic drugs and
12 Pages(3000 words)Essay
The major operating system and network you are using on a daily basis
The major operating system most used on a daily basis on our desktop computers is the Microsoft Windows 8.1 operating system (OS), the latest generation of the Microsoft Windows NT OS series. Microsoft Windows NT OS, would be classed as a major transformational OS running desktop computers.
4 Pages(1000 words)Essay
Molecular Therapeutics
Hamberg and Samuelson were eventually able to clearly elucidate the mechanism of prostaglandin biosynthesis in 1967 (Lawrence, et. al.1999). It became clear, afterwards, that prostaglandins were formed from polyunsaturated fatty acids by a complex reaction involving oxygenation, cyclization and the generation of five chiral centres from an achiral substrate (Lawrence et al 1999).
6 Pages(1500 words)Essay
Molecular Identity
These are all sodium/potassium-coupled chloride cotransporters described succinctly below. They can be functionally classified broadly into four groups according to the cation coupling to the chloride ion, the stoichiometry of the transport process and the relative sensitivities to inhibitors.
12 Pages(3000 words)Essay
Molecular Identity Essay
The CAD cell line is specifically neuronal, a characteristic that is very suitable for KCC2 study as the cotransporter too is neuronal specific. Specific association between the culture cell line and the cotransporter has not been made in this paper. That has been left to the dissertation that shall elucidate in full the results of the research experiments.
10 Pages(2500 words)Essay
Molecular Biology
The disease is normally mild. Pertussis has remained to be an endemic in the entire world and is considered to A clear understanding of the biological functions of the
12 Pages(3000 words)Essay
Molecular Biology
Monoclonal antibodies can be obtained by intraperitoneal injection into mice and collection of ascetic fluid produced. Since it is difficult to to remove antigenicity from the mouse, in vitro
8 Pages(2000 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic Investigating the molecular basis of oligomerisation specificity using coiled coil peptides for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us