Nobody downloaded yet

Chemistry - Vitamin B12 - Research Paper Example

Comments (0) Cite this document
15 April 2012 Vitamin B12 Vitamin B12 (cobalamine), the last vitamin to be discovered, is a cobalt-containing compound (Insel et al. 452; Gropper, Smith and Groff 359). While it was isolated by Smith, its structure was identified by Hodgkin, and its utility in eliminating diseases such as pernicious anemia was demonstrated by Minot and Murphy (Gropper, Smith and Groff 359)…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER91.8% of users find it useful
Chemistry Research Paper - Vitamin B12
Read TextPreview

Extract of sample
"Chemistry - Vitamin B12"

Download file to see previous pages The cobalt ? position, which is the region below the corrin ring plane, may either be open or could be occupied by a side chain of a heterocyclic nitrogen or the solvent (Combs 55). Methyl, nitro, aqua, sulfato, sulfito, hydroxo, 5-deoxyadenosyl, Br-, CN- or a Cl- group may occupy the cobalt ? position, which is the region above the corrin ring plane (Combs 55). The molecule is an octahedral complex, which apart from the corrin ring, also contains a nucleotide along with another cobalt bound group. The corrin ring is formed of four pyrrole rings, three of which are linked with methylene bridges and one with a direct bond. The cobalt atom (Co3+) at the center of the corrin ring is triply ionized and is bound to the nitrogen atoms of the four pyrrole rings (Combs 56). Chemistry Removal of the central cobalt atom of the molecule results in loss of biological activity. Like all corrinoids, vitamin B12 is a crystalline substance with absorption spectra above 300 nm due to ?-? transitions in the corrin ring (Combs 56). It is yellow, red or red-orange in color, is soluble in water, fairly heat stable, and decomposes above 210°C (Combs 57). ...
Functions and Mechanism Vitamin B12 has a key role in the metabolism of folate in the human body (Insel et al. 452). It transfers a methyl group from the folate coenzyme Tetrahydrofolic acid (THFA) converting THFA to its methylene form. In absence of the vitamin, THFA cannot transform into its methylene form, which is its active form that is involved in many metabolic pathways (Insel et al. 452). As THFA is involved in folate metabolism, deficiency of vitamin B12 results in the deficiency of folate because of absence of active form of THFA. Therefore, vitamin B12 deficiency amounts to folate deficiency, which in turn leads to megaloblastic anemia. Several enzymes that convert homocysteine to methionine are also dependant on vitamin B12 and THFA. Conversion of homocysteine to methionine reduces the levels of homocysteine in the blood, thereby lowering the risk of heart diseases. This mechanism is affected in case of vitamin B12 deficiency (Insel et al. 453). Vitamin B12 also functions in the maintenance of the myelin sheath, which is a protective coat surrounding nerve fibres (Insel et al. 453). Moreover, some fatty acid chains require rearrangement of their carbon atoms in order to enter the citric acid cycle. This function is also performed by vitamin B12 (Insel et al. 453). Vitamin B12 is stored in the liver and can last for about 2 years, while the symptoms of its deficiency may not be apparent for up to almost 12 years (Insel et al. 454). Anemia is the major outcome of vitamin B12 deficiency. In absence of vitamin B12 and in turn, folate, megaloblasts are formed instead of red blood cells, leading to megaloblastic anemia. Vitamin B12 deficiency also results in cognitive defects by causing ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Chemistry Research Paper - Vitamin B12 Example | Topics and Well Written Essays - 1000 words”, n.d.)
Retrieved from
(Chemistry Research Paper - Vitamin B12 Example | Topics and Well Written Essays - 1000 Words)
“Chemistry Research Paper - Vitamin B12 Example | Topics and Well Written Essays - 1000 Words”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Research paper on a problem pertinent to my academic major (chemistry). Discuss and research the problem and danger of being exp
The risk involved could range from a simple skin cut to death. In fact, four reported death has occurred in Chemistry laboratory between January 2011 to May 2011 (The Laboratory Safety Institute, 2011). Causes of these preventable fatal accidents are as varied and are usually associated with explosion, implosion, fire, exposure to toxic chemicals, radiation (ionizing and non-ionizing), and biohazard.
8 Pages(2000 words)Research Paper
Medical uses of algae
In terms of physiology, they are basically autotrophic with all their materials from inorganic sources and photosynthetic producing complex carbon compounds from CO2 and light energy. Some algae are secondarily heterotrophic but retaining fundamental
20 Pages(5000 words)Research Paper
Calcium Element Chemistry Research Paper
(Earnshaw and Greenwood, p. 109) It has been known since ancient times in its carbonate form as limestone, from which the Romans produced lime, called calyx in Latin. (Helmenstine, p. 1)The metal form of calcium was discovered by the English scientist Sir Humphrey Davy, in his laboratory in London in 1808.
3 Pages(750 words)Research Paper
It is an essential element in things as essential as water, as small as healing cuts and bruises, and as large and industrial as oil refinement. This essay
7 Pages(1750 words)Research Paper
Vitamin D
The need for vitamin D in the human body was discovered during the early twentieth century, when Sir Edward Mellanby, linked the fact that the amount of vitamin D found within a human body can be correlated to certain medical conditions like osteomalacia (soft/weak bones in human adults) and rickets.
10 Pages(2500 words)Research Paper
Vitamin B12
Vitamins are further divided into water soluble and fat soluble. The B family of Vitamins constitutes the water soluble part; the B family itself is a large one and contains vitamins like B1, B2, B3, B5, B6 and B12. Vitamin
2 Pages(500 words)Research Paper
Research paper
In this regard, most societies hold the opinion that individuals who grow up with autonomy-thwarting parents have lower chances of exploring their sexual values and identities and therefore disregard social aspects that
2 Pages(500 words)Research Paper
Research Paper
According to Wikipedia (Toyota, n.d.), the company was founded in 1933 with the division of Toyoda Automatic Loom Works that was devoted to the production of automobiles. However, in 1937 it already performed its activities as an independent company. Since its
5 Pages(1250 words)Research Paper
Research Paper
The world population has always been increasing past the food supply, genetically modified foods are meant to close the gap between food supply and human consumption. The main benefits of this technology are
6 Pages(1500 words)Research Paper
Research paper
The research is done via a primary as well as secondary research to arrive at definitive findings and conclusions so as to suggest practical recommendations to address the issue. The
10 Pages(2500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Research Paper on topic Chemistry Research Paper - Vitamin B12 for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us