Cancer Biology and MicroRNAs - Essay Example

Comments (0) Cite this document
This work will look at the role of the microRNAs in cancer. Regulation of genes is important in gene expression. Studies have shown that micro RNAs are important in cancer developmental stages such as proliferation, apoptosis and invasion. This essay will address these roles in cancer development…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER93.8% of users find it useful
Cancer Biology and MicroRNAs
Read TextPreview

Extract of sample "Cancer Biology and MicroRNAs"

Cancer Biology and MicroRNAs
Just like the DNA, the RNA is made up of coding and non-coding regions. The coding regions are responsible for gene expression. Looking at the central dogma and the transfer of a characteristic from the gene to the final protein, the genetic material is stored in the DNA which is then transferred to the RNA by transcription. These various RNAs then decide how the amino acids will be coded to make the final protein chain and hence the expression of the genes. MicroRNAs however, are non-coding which means that they are not involved in the transcription and the translation process in any way. They are small molecules and they contain about twenty to twenty five nucleotides.
The role of the micro RNAs is to regulate gene expression as the work of the coding RNA needs to be streamlined to avoid abnormal or wrong coding. They are also very important in RNA silencing which involves suppressing the effect of a gene or more than one gene after coding has taken place (Dutta & Lee, 2010). This can also be important in the elimination of certain unwanted genes form the body. RNA silencing involves the use of antisense RNA which is used in the gene silencing. This work will look at the role of the microRNAs in cancer. Regulation of genes is important in gene expression. Studies have shown that micro RNAs are important in cancer developmental stages such as proliferation, apoptosis and invasion. This essay will address these roles in cancer development.

Understanding miRNA
The identification of the two were among the greatest works done in this field in the last century. Of more importance is the realization that miRNA were significant players in the etiology of cancer. Further studies have shown that the miRNAs can be used in cancer therapy and so understanding their nature existence and roles is of great importance to molecular biology. miRNAs are often expressed differently in various stages of development in the organism an aspect that made them to be called small temporal RNA due to their temporary expression (Dutta & Lee, 2010). The techniques used to measure their expression include Northern blotting and primer extension assay. This have been developed to help in understanding the small aspects of DNA and RNA that scientists could have ignored or bypassed in the past.
Post Transcriptional Suppression
As highlighted earlier, micro RNAs play a role in suppressing target messenger RNA expression. This is a complex interaction which includes interacting with 3’UTR in the mRNA. What has been noted is that there are many mismatches in the micro RNA target sites a situation that is still being probed to establish the cause and effects in gene mRNA expression. miRNA is also known to inhibit or decrease the target levels in the respective mRNA and so this can affect the organism adversely or serve as a predisposing factor for cancer (Dutta & Lee, 2010).

Cited Work
Dutta, Anindya. & Lee, S. Yong. MicroRNAs in Cancer. US National Library of Medicine. 2010. Available at. Read More
Cite this document
  • APA
  • MLA
(“Cancer Biology and MicroRNAs Essay Example | Topics and Well Written Essays - 500 words”, n.d.)
Retrieved from
(Cancer Biology and MicroRNAs Essay Example | Topics and Well Written Essays - 500 Words)
“Cancer Biology and MicroRNAs Essay Example | Topics and Well Written Essays - 500 Words”, n.d.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Cancer Biology and MicroRNAs


...?Genetics and Evolution In philosophy, the thought of where humans came from was deeply rooted in religion and thoughts concerning the natural world.Much was derived from religion and myth, often from the basis of creation stories involving the creation from supernatural beings. As new intellectual revolutions in science began to take place, early scientists began to search for reasons as to explain this phenomenon. Much of the first data that was gathered was based on natural observations due to the lack of scientific understanding as well as lack of analyzing technique. Some of the first scientists to pioneer into the field of modern genetics and evolution were Gregor Mendel and Charles Darwin. Gregor Mendel was an Austrian monk...
6 Pages(1500 words)Essay

Cancer Biology Research Paper its phenotype. The metabolic phenotype of this cell is monitored by the changes in the genetic structure of the cells as well as the changes that are taking place outside the cancerous cells in the normal tissues. It was deduced that the changes in the metabolism are a very significant feature of the cancer cells and they form the basis for the rapid multiplication of these cells. Cancerous signals are transmitted to these cells which result in the cascade of duplication. The target of these biologists and researches is to find a way to slow down the metabolism of the tumor “progression” so as to enhance the treatment of cancer and produce excellent results (Cairns et...
5 Pages(1250 words)Research Paper

Cancer and Biology

...? Cancer and biology Cancer and biology Cancer describes diseases whose growth of cells is beyond control. There are numerous categories of cancer with each category exuding distinct tendencies based on areas initially affected. Scientists report that more than one hundred cancer types exist in the world today. The presence of cancer in the body leads to the damage of the body cells that undergo unrestrained division to form tumors. Consequently, tumors correspond to lumps of tissue. It is only in the case of leukemia that cancer does not allow division of the cell as the normal function of the blood. The growth of the tumors leads to the interference of circulatory, digestive and the nervous systems. Tumors also release hormones... on the...
4 Pages(1000 words)Research Paper

The role of microRNAs in breast cancer

...? The Role of MiRNA in Breast Cancer Introduction MicroRNAs are non-coding RNAs that exist naturally and use mRNAs translational cleavage or repression to control gene expression. MicroRNAs have been associated with breast cancer as a causative factor and as a means to solving the problem (Yamashita et al, n.d., p. 331). Recent investigations have targeted miRNAs because of their high possibility in solving problems in cancer therapy. So many miRNAs have been associated with different types of human cancers such as lung cancer, papillary thyroid carcinoma, breast cancer, colon carcinoma, and gastric...
7 Pages(1750 words)Essay


...Biology Questions Give a specific example of how natural selection drives evolution Through the process of natural selection as explained by Charles Darwin, all organisms’ exhibit variations which are genetically inherited. Those variations that are better suited to survive in a particular environment are selected by nature through the process of natural selection. These organisms in turn produce offspring’s with similar traits and better adaptation to survive. This contributes to the process of evolution. A fine example of natural selection is provided by the finches that were observed by Darwin during his expedition to the Galapagos’ islands. He found 13 species of finches and each species exhibited variation is beak...
3 Pages(750 words)Essay


..., the nucleus, and negatively charged particles called electrons that are found in orbits around the nucleus. Molecules are made up of two or more atoms, either of the same element or of two or more different elements, joined by one or more covalent chemical bonds. Cell1 In biology, it is the unit of structure and function of which all plants and animals are composed. The cell is the smallest unit in the living organism that is capable of integrating the essential life processes. Cells can be separated into two major groups—prokaryotes, cells whose DNA is not segregated within a well-defined nucleus surrounded by a membranous nuclear envelope, and eukaryotes, those with a membrane-enveloped nucleus. Within cells there is...
2 Pages(500 words)Essay


...the patient breathe. While still negative of the disease, it is wise to pay attention on the prevention of the disease thru following good hygiene habits such as washing the hands frequently with warm soapy water, using separate drinking glasses and eating utensils, and coughing or sneezing into a tissue. Stay healthy and boost the immune system by eating healthy foods, sleep well, avoid smoking, exercise, reduce stress, and not drinking excessive alcohol (The Patient Education Institute, Inc., 2008). References Kimball, J.W. (2007). The Human Respiratory System. Biology. Last accessed online on April 10, 2009 at <> (2008). Pneumonia:...
2 Pages(500 words)Essay


... of the cure for cancer, but it may be in the stem cells that they are opposing. This shows the split between religion and science which often also divides the American political parties in terms of adherence to certain standards. In any case, this is a divisive political issue that is very controversial. This process is set to solve problematic issues in medical and genetics-based sciences currently because no cells match the individual in terms of rejection or acceptance of the cells like the individual’s own cloned cells. REFERENCE Verfaillie, Catherine (2007). Stem Cell Biology Research. University of Minnesota Cancer Center. res2.html.... and help individuals improve their health and...
3 Pages(750 words)Essay

Modeling cancer biology

...Article Review Cobb, Kristin. Modeling Cancer Biology, Biomedical Computation Review, (Spring, 2007), 3 (2), 16-24. In this article Dr. Kristine Cobb explains, citing evidence from joint experiments by mathematicians and biologists, how mathematical models are transforming the fight against cancer. The article points out that the mathematicians’ works are rarely referred to or put to use by the biologists and stresses the need for collaborative work between them in the light of the benefits revealed by the cases cited. For example, Dr. Natalia Komaroa models the inactivation of APC tumour suppressor gene, the initiating event in colon cancer, for estimating the number of...
1 Pages(250 words)Article


...Biology Barbara McClintock McClintock was a research scientist who studied how chromosomes in maize changed and how they underwent transformation during their reproduction stages (Spangenburg & Moser 35-41). Through her laboratory research, she was able to develop a groundbreaking method of observing maize chromosomes as they developed. Spangenburg & Moser write that she used microscopic inquiry to explain different genetic developments (35-41). By narrating the process of genetic recombination during meiosis, she developed a maize genetic map. Finally, she elaborated on the role of centromere and telomere the central part of genetic transformation in maize (Spangenburg & Moser 38). Using the developed theories, she was...
1 Pages(250 words)Admission/Application Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Cancer Biology and MicroRNAs for FREE!

Contact Us