quora
Nobody downloaded yet

Introduction about cell cycle by emphasizing DNA replication - Research Paper Example

Comments (0) Cite this document
Summary
DNA replication, one of the most important elements of the cell cycle, occurs during the S phase, relying on a precise assembly of pre-replicated complexes (RCs)…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER95.6% of users find it useful
Introduction about cell cycle by emphasizing DNA replication
Read TextPreview

Extract of sample
"Introduction about cell cycle by emphasizing DNA replication"

Download file to see previous pages Evidently, there is a need to ensure that DNA replication occurs only once per cell cycle to prevent daughter cells having inappropriate copy numbers and other potentially fatal errors (Byun et al, 2005, Lou et al, 2008, Kurth& Gautier, 2010). This means that DNA replication is tightly controlled by a number of different cell elements, including RCs and the cyclin-dependent kinase (CdK) known as Cdc28p (Drury, Perkins &Diffley, 2000). The CdK family is important in cell cycle regulation as they phosphorylate proteins involved in cell cycle checkpoints.
During the assembly of RCs at an origin, a family of proteins (Mcm2-7) becomes associated with the DNA (Randell et al, 2010, Lydeard et al, 2010), a mechanism that requires the origin-recognition complex (ORC) and Cdc6 (cell division cycle 6) (Randall et al, 2006). The loading of Mcm2-7 helicase onto origin-proximal DNA for replication is directed by the ORC and Cdc6, initiated by sequential ATP hydrolysis (Randall et al, 2006). This occurs at a precise time during G1 in part due to the mechanisms of Cdc28p (Drury et al, 2000), which plays the dual function of preventing RC formation and initiating the replication of DNA within the cell cycle (Drury et al, 2010). Cdc6p is also important in the cell cycle because it prevents DNA re-replication, as without it there may be multiple rounds of DNA re-replication without the mitosis event (Drury et al, 2010). It is possible to judge which phase of the cell cycle a cell is at through levels of Cdc6p: high during G1 and then gets phosphorylated during the S phase (Rizzardi& Cook, 2013).
Perkins, Drury &Diffley (2001) showed the importance of CDC6 by introducing mutant alleles of the CDC6 gene. Two major transformants of CDC6 were chosen. CDC6-d1 ensured that the cell could not progress onto S phase, as there was abnormal assembly of the pre-RC complex. CDC6-d2 ensured that ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Introduction about cell cycle by emphasizing DNA replication Research Paper”, n.d.)
Introduction about cell cycle by emphasizing DNA replication Research Paper. Retrieved from https://studentshare.org/biology/1621247-introduction-about-cell-cycle-by-emphasizing-dna-replication
(Introduction about Cell Cycle by Emphasizing DNA Replication Research Paper)
Introduction about Cell Cycle by Emphasizing DNA Replication Research Paper. https://studentshare.org/biology/1621247-introduction-about-cell-cycle-by-emphasizing-dna-replication.
“Introduction about Cell Cycle by Emphasizing DNA Replication Research Paper”, n.d. https://studentshare.org/biology/1621247-introduction-about-cell-cycle-by-emphasizing-dna-replication.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
DNA Evidence
Historically, DNA evidence began in the forensic field when ABO blood group was used as a system in providing evidence of crime issues. Later, the paternity identification that based on serum protein variation became commonly used. However, it was not until when Jeffrey became a pioneer of DNA based identity testing.
3 Pages(750 words)Research Paper
Impact of DNA damage induced by anticancer drugs on both S phase and mitosis phase of the cell cycle
Many genetic changes happen when a normal cell is converted to a cancer cell (Hartwell & Kastan 1994). In a carcinoma cell the normal order and the functions of a cell are impaired and the usual limits of cell division are ignored. This condition may arise as a result of a mutation / change of the genetic sequence or due to DNA damage and it is important to note that the ‘growth fraction’ (ratio of proliferating cells to cells in resting stage) is remarkably high in carcinoma cells than in normal cells (Eidukevicius et al.
4 Pages(1000 words)Essay
DNA Repair Mechanisms
Since different strains of the bacteria react differently to gene replacement with lacS gene, these researchers hypothesize that different S. solfataricus strains have different DNA processes as well, including their repair mechanisms. First, each strain was cultured using 0.2 to 0.4 in basal salts medium with 0.1% (wt/vol) sucrose and 0.1% (wt/vol) tryptone (ST medium) or 0.2% (wt/vol) glucose and 0.2% (wt/vol) tryptone (GT medium) prior to UV exposure.
4 Pages(1000 words)Research Paper
DNA Fingerprinting
Name Institution Course Instructor Date DNA Fingerprinting Abstract DNA fingerprinting is a laboratory procedure that has proved very useful in personal identification. With its wide applications, it is causing a revolution in the modern world. Typing of DNA presents unique profiles for each individual except identical twins.
5 Pages(1250 words)Research Paper
The Cell Cycle
Mitosis, on the other hand, involves division of nuclear chromosomes. It has four phases namely the prophase, metaphase, anaphase, and telophase. In prophase, chromatin material is condensed into distinct chromosomes that migrate to the center of the cell. At the opposite poles of the cell, there is the formation of spindle fibers.
2 Pages(500 words)Essay
Optimizing the condition of the PCR detecting of PTEN gene in DNA derived from human cell lines, associated with ageing and senescence
Over the past several years, there has been an emerging aging research theme linking cellular processes influencing cancer with those influencing
15 Pages(3750 words)Research Paper
Cell cycle by emphasizing DNA replication
nts derived are then transformed into yeast then plated plates containing glucose, obtain galactose containing plates and replica plate transformants so as to induce the expression of mutant proteins. Of the transformants, only two (CDC6-d1 and CDC6-d2) grew on glucose but not
5 Pages(1250 words)Research Paper
DNA fingerprinting
Every strand is composed of nucleotides, a sequence of bases. A base can be one of the four chemicals, adenine, thymine, cytosine, or guanine. The two DNA strands are connected to every base. Bases can only bond with each other as follows: Guanine (G) can only bond
3 Pages(750 words)Research Paper
Cell Cycle Progression: A Coordinated Act of Cyclins, Cdks and Checkpoints
The cell cycle consists of two major steps: Interphase and mitotic phase. The cell spends most of its time in the interphase. In this phase, the cell grows, doubles the contents and duplicates the DNA. The interphase consists of 4 sub phases. They are G1 phase, S phase, G2 phase and Mitotic phase.
5 Pages(1250 words)Research Paper
A Study of Chromosome formation through observation of the cell cycle (Abstract)
The key to this process is observing the cell-cycle. Cell divisions occur in two parts: the interphase and the miotic phase, the former of which can be further sub-divided into the G1, S and G2 phase. We observed the somatic cell division and meiosis stages to get an understanding of the process of chromosomal formation.
2 Pages(500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Research Paper on topic Introduction about cell cycle by emphasizing DNA replication for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us