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The projects looks at the relationship between the SHGB and PCOS and focuses on the molecular basis of disease and how the changes in the SHBG gene relate to the disease as well as to other health conditions such as cancer.
SHBG is the principal plasma transport protein for sex steroid hormones and it controls the bioavailability of these hormones to the target tissues. The gene encoding SHBG is compound and any of numerous polymorphisms in SHBG have been linked with changes in circulating SHBG levels. Studies of Epidemiological have shown that low plasma SHBG levels are an insulin resistance early indicator and they can predict the development of type diabetes mellitus 2 (T2DM) in both women and men (Chittenden & Maheshwari, 2009).
The sex hormone-binding globulin gene is also known as (ABP) androgen binding protein. Even though, associations linking low SHBG levels and the risk of diabetes might be explained by the theory that elevations in insulin levels suppress the production of hepatic SHBG (Cangemi et al, 2011), modern studies are documenting that the SHBG-altering polymorphisms transmission are connected with risk of T2DM imply that SHBG can have an additional direct physiologic task in glucose homeostasis. Nevertheless, the precise mechanisms underlying this connection are unknown. A non-diabetic woman with the (PCOS) polycystic ovary syndrome, a widespread endocrine disorder that is linked with insulin resistance, similarly demonstrates lower SHBG levels. In this report, we evaluate studies investigating the connection between SHBG polymorphisms and PCOS. Numerous studies in women with PCOS prove that certain genetic polymorphisms are connected with circulating SHBG levels, but they are not constantly connected with PCOS. (Chen et al. 2010)
The SHBG has a number of functions that include steroid binding, physiological functions
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“Human Genome Project (PCR) Essay Example | Topics and Well Written Essays - 3000 Words - 1”, n.d. https://studentshare.org/biology/1617553-human-genome-project-pcr.
Scientists and policymakers alike are testifying to the potential benefits of the human genome project. But ethicists and theologians are opposing the project based on the ethical concerns it raises. This essay tries to answer three of the major questions the human genome project poses: (1) What will the world look like in regard to genetic testing, genetic engineering, and cloning; (2) can the information learned from the Human Genome Project be used to eradicate disease; (3) what are the ethical implications and how might this power be misused?
The human genome project represents an effort to determine more than 3 billion nucleotides located within the human genome and to identify the genes that are present. Before the project was initiated, the US Department of Energy supported work that was done in the course of several years, which culminated with initiative given by the Department of Energy in 1986.
(Human, 2006). The significance of the project is indicated by the major initiative taken by the Government keeping in view its overall benefits to the public. It is also natural that the private sector which primarily operates on the basis of profit making only seeks projects which have a scope of providing substantial returns.
Between the genome decoding and the appearance of new wonder, medicine is a great distance to reach. Usually, it takes about 10-12 years to test, to create the proper medicaments, and to release them on sale. However, what we have today, is the decoded genome only, and the human body contains about 30 000 different genes.
and there are issues of bioethics that surround it because some people think that the project will lead to eugenics and the formation of structural inequality theory based on genetics. “Yet despite this impact on society as a whole, legislation on the regulation of
Abnormal pairing or alteration in pairing of DNA bases results to varieties of genetic complications, which can be inheritable. Several studies have been carried in an attempt to explore more about genome. Various institutions and projects have, thus, been
The author asserted that decoding the human genome would result in better understanding and advantages for human health. However, some scientists opposed the move fearing that this kind of project would lead to a product that would be of little benefit to human beings. The Human Genome Project began in 1990.
Genetic test records may form the basis of decisions made by parities such as insurers and employers and this negatively affects the people with the “wrong gene” (Schoonmaker and Williams 30).
The groups working
It is also creating novel personalized ways of treating common diseases. The varied disorders that have genetic bases and that may accrue a viable treatment from the human genome project are heart diseases, diabetes, asthma, cancer, hemophilia, sickle cell anemia, and
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