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Human genome project (PCR) - Essay Example

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The gene plays an important role in the steroid response control as it helps in the movement of sex steroids into the target…
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Human genome project (PCR)
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Download file to see previous pages The projects looks at the relationship between the SHGB and PCOS and focuses on the molecular basis of disease and how the changes in the SHBG gene relate to the disease as well as to other health conditions such as cancer.
SHBG is the principal plasma transport protein for sex steroid hormones and it controls the bioavailability of these hormones to the target tissues. The gene encoding SHBG is compound and any of numerous polymorphisms in SHBG have been linked with changes in circulating SHBG levels. Studies of Epidemiological have shown that low plasma SHBG levels are an insulin resistance early indicator and they can predict the development of type diabetes mellitus 2 (T2DM) in both women and men (Chittenden & Maheshwari, 2009).
The sex hormone-binding globulin gene is also known as (ABP) androgen binding protein. Even though, associations linking low SHBG levels and the risk of diabetes might be explained by the theory that elevations in insulin levels suppress the production of hepatic SHBG (Cangemi et al, 2011), modern studies are documenting that the SHBG-altering polymorphisms transmission are connected with risk of T2DM imply that SHBG can have an additional direct physiologic task in glucose homeostasis. Nevertheless, the precise mechanisms underlying this connection are unknown. A non-diabetic woman with the (PCOS) polycystic ovary syndrome, a widespread endocrine disorder that is linked with insulin resistance, similarly demonstrates lower SHBG levels. In this report, we evaluate studies investigating the connection between SHBG polymorphisms and PCOS. Numerous studies in women with PCOS prove that certain genetic polymorphisms are connected with circulating SHBG levels, but they are not constantly connected with PCOS. (Chen et al. 2010)
The SHBG has a number of functions that include steroid binding, physiological functions ...Download file to see next pagesRead More
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