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Caveolin protein - Essay Example

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Since the caveolin serve as the caveolae coat protein, the caveolin is considered as a major element of the caveolae which represents as…
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Download file to see previous pages l of three (3) variants known as the caveloin-1 (CAV-1), caveolin-2 (CAV-2), and caveolin-3 (CAV-3) (Gussak and Antezelevitch 234; Williams and Lisanti). CAV-1 and CAV-2 can be found in most cells whereas CAV-3 can be found in muscle cells of the heart (Yuan, Garcia and Hales 275).
Having a complete sequence status, the size of amino acid length of CAV-1 is 178 (UniProtKB). As a 21- to 24-kDa protein, CAV-1 is composed of 16 amino acids longer than CAV-2 and additional N-terminal 27 amino acids as compared to CAV-3 (Fielding 177). CAV-1 has two variants known as CAV-1α (contains amino acid tyrosin 14) and CAV-1β (does not contain the “first 31 amino acid present in CAV 1α) (Mercier, Jasmin and Lisanti 18). Both CAV-1α and 1β can be found in the lungs whereas CAV-1β can be found in the epithelial cells (Yuan, Garcia and Hales 275).
With regards to internalization of the material, Garcia and Hales (275) explained that CAV-1 can be phosphorylated in “Rab4-labelled, Rab5-labelled or the early endosome antigen-1-labelled compartments which then subsequently move to the Rab11-associated compartment”.
Tang, ZhaoLan, Philipp E. Scherer, Takashi Okamoto, et al. "Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle." Journal of Biological Chemistry 271.4 (1996): ...Download file to see next pagesRead More
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