quora
Nobody downloaded yet

Recessive Lethal Mutations - Essay Example

Comments (0) Cite this document
Summary
George Streisinger pioneered the potential of zebrafish as a vertebrate organism suitable for forward genetics screening research, about twenty years ago. In the laboratory environment zebrafish are easily handled…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.8% of users find it useful
Recessive Lethal Mutations
Read TextPreview

Extract of sample
"Recessive Lethal Mutations"

Download file to see previous pages Recessive Lethal Mutations

In order to understand how genes specify a biological process of both phenotypes that can occure and the number of genes involve, it is important identifying the mutated genes. Because high mutation frequencies can be obtain with chemical mutagens. Actually the mutation frequency can vary widely for different loci, chemical mutagens can induce mutation in most genes. With all these advantages, there is still some disadvantage associate with it because cloning mutant gene is difficult, as these chemicals usually cause point mutations. Positioning cloning chemical induce mutants are made feasible over time, but cloning remain expensive and laborious in vertebrate animal with large genomes. A less effective approach to chemical mutagenesis that greatly speeds the cloning of mutant genes is known as insertional mutagenesis. The integration of exogenous DNA sequences into a genome can be mutagenic, and the inserted DNA serves as a tag to clone mutated genes, though fewer lesions are obtained per genome and also insertional mutagens seldom, if integrated randomly into host DNA.

When large-scale genetic screening is carried out, it results in successful identification of many genes that define embryological pathways. However, two scientists from Boston and Tubingen are inspired by the remarkable characteristic of the zebrafish, along with the first zebrafish genetic screening identified mutant embryonic phenotype in F3 generation. Some of the mutated developmental genes identified in the two screens have been cloned, which assist in the dissection of the gene network that controls the early development. For example, the mutated genes in the endoderm mutants such as casanova, bonnie and clyde, and faust can be assembled into a genetic pathway that have been shown tom encode transcription factors that are necessary for endoderm formation. Analysis of proviral insertions has revealed that different germ cell are infected independently in F1 progeny and with high titer virus stocks they often have multiple integrations and any given insertion is transmitted mosaically to between 1% and 40% of the F1 pronegy. Individual F1 fish can inherit multiple insertion and proviral insertions in F1 fish and transmitted in a mendelian fashion.
When outcrossing founder fish, identified F1 fish with single proviral insertion, generated an F2 family for each insertion, and then inbred transgenic F2 fish and examined F3 progeny to identify mutation. This system is not too efficient for large-scale screen because each insertion was inbred individually, therefore ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Recessive Lethal Mutations Essay Example | Topics and Well Written Essays - 1000 words”, n.d.)
Retrieved from https://studentshare.org/biology/1533087-recessive-lethal-mutations
(Recessive Lethal Mutations Essay Example | Topics and Well Written Essays - 1000 Words)
https://studentshare.org/biology/1533087-recessive-lethal-mutations.
“Recessive Lethal Mutations Essay Example | Topics and Well Written Essays - 1000 Words”, n.d. https://studentshare.org/biology/1533087-recessive-lethal-mutations.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
A Lethal Lack of Industry. Walden by Henry David Thoreau
One can glean some redeeming arguments from Thoreau’s overall philosophy, even though it condemns industrial progress. Literary criticism of Thoreau’s Walden elaborates on his ideals: “Simplicity is good for the soul, for the right relation with God,” (McKibben 20).
5 Pages(1250 words)Essay
Investigation of Human Disease
Functionally, it synthesizes substances of almost all clotting factors necessary in coagulation process. Meanwhile, vitamin K, which is synthesized in the intestine by bacteria, is also necessary for hepatic synthesis of prothrombin, serum prothrombin conversion accelerator or factor VII, plasma thromboplastin component or factor IX, factor X, and protein C.
6 Pages(1500 words)Essay
What Causes Cancer Mutations
What Causes Cancer Mutations? Cancer is known as malignant neoplasm, the hallmark characteristic involves uncontrolled proliferation of cells. Under normal conditions cells grow, divide and die, but in a genetic defect called mutation occur in cancer cells leading to the formation of an abnormal DNA.
6 Pages(1500 words)Essay
He similarities and differences between autosomal recessive and sex-linked recessive conditions
Only offspring with both recessive alleles, meaning both parents are heterozygous carriers of the recessive genes will be affected. These disorders are present in only about 2.5 per 1000 live births, and will not be manifested is the offspring receives a dominant allele from either parent
15 Pages(3750 words)Essay
Homeostasis
These proteins encoded by genes perform different functions in the body. The arrangement of these bases in the genetic machinery is done in a sequence. Any abnormality in genetic
5 Pages(1250 words)Essay
Mutations
The repair pathway has been linked to colon cancer in humans via association between MI in colon tumours found in HNPCC families. MIs are short and repetitive sequences that are incorrectly copied by the DNA polymerase since the template and daughter strands found in the region are prone to misalignment.
3 Pages(750 words)Essay
P53 mutations and Cancer
If we have to differentiate between the normal cells and cancer cells, it can be noted that the cancer cell seems to have lost a number of vital control systems. Here comes the concept of genes which is the most important ingredient in the cell responsible for multiplication.
4 Pages(1000 words)Essay
DNA Mutations
Resultantly the mRNA transcribed from that particular changed or damaged gene will carry an entirely different genetic message (Blamire ,2000). The polypeptide created as a result of the translation of the
2 Pages(500 words)Essay
Factor V Leiden and Prothrombin Mutations
The overall evaluation of this journal is to investigate the relationship between factor V Leiden, recurrent miscarriages, c677T methylenetetrahydrofolate, and prothrombin G20210A. In this case study, the prevalence of factor V Leiden,
2 Pages(500 words)Essay
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Essay on topic Recessive Lethal Mutations for FREE!
logo footer
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us