StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Molecular Mechanism of antibiotic resistance in Escherichia coli - Essay Example

Comments (0) Cite this document
Summary
Molecular Mechanism of antibiotic resistance in Escherichia coli Name: Unit: Instructor: Date: Abstract Background: Resistance to antibiotics in E.coli and other bacteria is conferred to them by gene transfers and mutations. The main aims and outcomes of such are strains that are more virulent and tolerant to harsh conditions crated by antibiotic therapy…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.8% of users find it useful
Molecular Mechanism of antibiotic resistance in Escherichia coli
Read TextPreview

Extract of sample "Molecular Mechanism of antibiotic resistance in Escherichia coli"

Download file to see previous pages Conclusion: Sufficient research results have shown that the E.coli continues to cause infections such as UTIs, resisting the basic ciprofloxacin. These strains are referred to as extended spectrum beta-lactamase E.coli. There is therefore need to develop new antibiotics and explore new ways of tackling the bacteria. Introduction Escherichia coli, commonly referred to as E. coli, are amongst the few organisms that have steered the art of antibiotic resistance in bacteria to altogether new levers. The European E. coli outbreak of 2011 served as an eye opener on the magnitude of harm such a development can cause. On that regard, it is vital to understand the antibiotic resistance mechanism of E. coli, especially at the molecular level. This implies that the quantification of the mechanism upon which this eventuality is realized will have to drench deep into the responsible genetic sequences in the DNA of the bacterium. Fortunately, the genetic sequence of E. coli is already established and safely stored in accessible archives. This is irrespective of the plasticity experienced while sequencing the DNA of E. coli. The main methods by which resistance is observed to occur include: Prevention of entry into the cell, Synthesis of enzymes that lyse the antibiotics, rapid efflux from the cell, and modification of the active site. Evaluation The quantification of the mechanism behind the resistance calls for the isolation of E. coli strains that exhibit this form of resistance. Due to the wide range of antibiotics availed for the fight against the spread of the bacteria, it is vital to focus on strains that exhibit multiple resistances. This is also of merit in a rather different perception in that; it can facilitate the development of antibiotics that encompass solutions to different targets. This helps in the improvement of their therapeutic efficacy. On this regard, a central region of focus falls under the integrons (these are genetic elements able to target and rearrange ORFs embedded in gene cassette units and change them to functional genes by ensuring their proper expression). This is with regards to their heightened presence in organisms exhibiting multiple antibiotic resistances. They were originally associated with gram negative bacteria. Progressively the analysis of strategic loci may be of great essence in the quantification of the avenues followed towards the establishment of a resistance in E. coli. Such a locus is the mar locus (Michael, 2007). On reference is that rapid mutations experienced in the mentioned locus; that eventuate into alteration of the coding sequence, hence aberration of the protein sequence produced. Apparently, the development of resistance towards a given antibiotic is based on two broad mechanisms. They include the development of mutated genetic sequence at the DNA level and the horizontal line gene transfer (also termed lateral gene transfer). This simply refers to the accumulation of various mutations via a systematic process; where the central microbe, in this case E. coli, accumulates the necessary mutation via prokaryotic DNA absorption mechanisms. This includes mechanisms such as transduction, transformation, gene transfer agents (found in alphaproteobacteria), or conjugation. The resistance sequences are conveyed along the various tandem sequences, such as transposons, integrons or plasmids (D’ ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Molecular Mechanism of antibiotic resistance in Escherichia coli Essay”, n.d.)
Retrieved from https://studentshare.org/biology/1465541-molecular-mechanism-of-antibiotic-resistance-in
(Molecular Mechanism of Antibiotic Resistance in Escherichia Coli Essay)
https://studentshare.org/biology/1465541-molecular-mechanism-of-antibiotic-resistance-in.
“Molecular Mechanism of Antibiotic Resistance in Escherichia Coli Essay”, n.d. https://studentshare.org/biology/1465541-molecular-mechanism-of-antibiotic-resistance-in.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document

CHECK THESE SAMPLES OF Molecular Mechanism of antibiotic resistance in Escherichia coli

Antibiotic Resistance of Bacteria

...? Antibiotic Resistance School Antibiotic Resistance Antibiotics have been increasingly used in the last six decades for the treatment ofinfectious diseases caused by microbes and bacteria. One of the most obvious causes of the increase in the expectancy of average life over the years is the antimicrobial chemotherapy. Nevertheless, microbes which are resistant to the therapy of antibiotic drug and yet cause the disease expose the people to a lot of health problems. Diseases which can not often be treated by the antibiotics include but are not limited to gonorrhea, pneumonia, wound infections, septicemia...
3 Pages(750 words)Research Paper

Escherichia Coli bacterium

...?Ar Escherichia Coli ESCHERICHIA COLI Introduction: Escherichia coli is a bacterium which is referred to as an enterobacteriacea that is a bacteria that exists normally in the intestine of human and animals. This bacterium which exists in the form of gram negative rods has been named after the man, Theodor Escherich who discovered them in the year 1885. This bacterium is not completely aerobic that is it can survive in the presence of oxygen and it also has the capability to exist in the absence of oxygen by the process of fermentation. E. coli also has the property of movement though there are certain forms of the bacteria that form exceptions and do not move. The mobility is provided to it by flagellum, which is referred... 0157:H7....
4 Pages(1000 words)Research Paper

Antibiotic resistance

...infectious diseases risk becoming uncontrollable and could derail the progress made towards reaching the targets of the health-related United Nations Millennium Development Goals set for 2015. " Other than these, antibiotic resistance also contributes to increased cost to health care and jeopardizes various health gains to the society. In this research article, various strategies to prevent emergence of antibiotic resistance will be discussed through review of suitable literature. The article will also discuss about causes and mechanism of antibiotic resistance and consequences of antibiotic...
3 Pages(750 words)Research Paper

ANTIBIOTIC RESISTANCE THREATS

...Threats due to antibiotic resistance Antibiotics are drugs which are used to fight out bacterial infections which help in alleviating the invading pathogen when taken appropriately. However, when these drugs are prescribed when they are actually not required they are not helpful in treating the disease and at the same time the patient is also exposed to the various side effects of the antibiotic. This gives rise to antibiotic resistance over time and the patients are at risk of developing resistant infections in future. These can cause serious illness or even death in the most resistant cases (U.S....
5 Pages(1250 words)Research Paper

Experiment on the bacterium Escherichia coli

...culture ha' been un'ucce''ful. Thi' partly, i' the ba'i' of the e'timate which is that less than 1% of all prokaryotes are known. The strain CU1 of E.coli was a clinical isolate recovered in 1997 which was found to be highly resistant to 14 and 16 membered ring macrolide antibiotics (Taniguchi K et al.). The Major Element' At an elementary level, the nutritional requirements of a bacterium 'uch a' E. coli are revealed by the bacterial cell's elemental composition that may consist of C, H, O, N, '. P, K, Mg, Fe, Ca, Mn, and trace' of Zn, Co, Cu, and Mo. The'e element' are found in the form of water, inorganic ion', 'mall molecule', and macromolecule' which 'erve either a 'tructural...
19 Pages(4750 words)Coursework

Escherichia coli

...And Infectious Diseases 2006) and hence calls for more research in this area. Research has provided enough profe that E. coli carry multidrug resistant plasmids and under stress conditions it may be readily transfer those plasmids to other species. Hence E. coli and the other enteroccia are important reservoirs of transferable antibiotic resistance. Some of the strains of E. coli, like Escherichia coli O157:H7, Escherichia coli O121 and E. coli O104:H21, are toxigenic. In other words they are capable of producing toxins and cause food poisoning, for...
8 Pages(2000 words)Essay

Antibiotic Resistance

...the antibiotic resistance genes are carried by the carrier molecules, for example:- scientist isolated both antibiotic sensitive and antibiotic resistant organism of the same serotype from patients with enteric infections being treated with sulphonamides, tetracycline’s, streptomycin, or chloramphenicol they went on to demonstrate that this was due to resistant genes in a reservoir of Escherichia coli in the intestinal tract being transferred to Shigella dysenteriae that caused the infection. Since than transfer of antibiotic resistant by bacterial...
5 Pages(1250 words)Essay

Bacteria resistance to antibiotic

...resistant, due to the evolution of various mechanisms over a period of time. These mechanisms modify the chemical structure of the antibiotic drug, render it inactive, and remove it from the cell. Some of these mechanisms modify the target site of the antibiotic drug and prevent the bacteria from being recognized by the drug. The most prevalent method is to make the antibiotic inactive by modifying the structure of its enzymes. Bacteria modify the existing cellular enzyme, by changing the chemical reaction with the antibiotic to divert the drug from attacking it. Several bacteria transform the target...
4 Pages(1000 words)Essay

Microbe Report on Escherichia coli

...Part I: Organism Information Organism Escherichia coli Organism Type: Bacteria Organism Structure: E. coli is a gram-negative bacterium with rod shaped cells 2.0 (μm) long with a diameter of 0.5 (μm). The bacterium grows best at 37°C but some strains have successfully multiplied in controlled laboratory settings at even 49°C. It is a facultative anaerobe reproducing using mixed-acid fermentation requiring low hydrogen levels to ferment simple sugars into formic acids. E. coli is also found with other hydrogen consuming organisms like sulphate-reducing bacteria (Hayhurst, 2004). Organism Characteristics: The bacterium is usually found in the lower intestinal tract of...
2 Pages(500 words)Lab Report

Escherichia Coli

... ESCHERICHIA COLI Introduction: Escherichia coli is a bacterium which is referred to as an enterobacteriacea that is a bacteria that exists normally in the intestine of human and animals. This bacterium which exists in the form of gram negative rods has been named after the man, Theodor Escherich who discovered them in the year 1885. This bacterium is not completely aerobic that is it can survive in the presence of oxygen and it also has the capability to exist in the absence of oxygen by the process of fermentation. E. coli also has the property of movement though there are certain forms of the bacteria that form exceptions and do not move. The mobility is provided... on the agars...
6 Pages(1500 words)Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Let us find you another Essay on topic Molecular Mechanism of antibiotic resistance in Escherichia coli for FREE!

Contact Us