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What Causes Cancer Mutations - Essay Example

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Cancer is curable in the present epoch if it is diagnosed in the early stages. The article deals with the genetic aspects, the risk factors associated with the cancer along with the symptoms diagnosis and management of the breast cancer. …
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What Causes Cancer Mutations
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Download file to see previous pages As genes are the basic control machine of the cells, alteration of any kind may bring devastating consequences, or malignancy. When compared with the normal cells, where damage of any kind is taken care by the repair system, tumor cells do not have any repair mechanism for the damaged DNA and there is a constant proliferation of cells without displaying senescence hence, generating a series of abnormal cells, with altered cellular pathways for uncontrolled proliferation, figuring malignant tumors (Alberts 2007; Katzang et al. 2009). The Genesis of a Cancer Cell A normal cell turns into a cancer cell because of one or more mutations in its DNA, which can be inherited or acquired. Mutation is sudden abrupt changes that occur in the genetic material i.e. the DNA of the cell. This genetic material is facilitated by various agents called mutagens. Mutagens can be either physical agents such as UV radiations, X-rays etc or they could be some chemical agents which are capable of producing changes in the cell by reacting with cellular macromolecules. These chemical agents form bond with the cellular macromolecules, thereby alter their normal structures. If they combine with the genetic material, the peptide formation is affected. Thus, these mutagenic agents affect the normal well being of the cell and when such a defective cell replicates the cellular modification is also passed on. These cellular alterations may lead to cancer, where the carcinogenic agents (cancer causing) are capable of altering the cell division leading to the uncontrolled proliferation of the cell (Alberts 2007; Chemical Carcinogens, Web.). In case of the breast cancer, woman who inherits a single defective copy of either of these tumor suppressor genes BRCA1 and BRCA2 displays an augmented risk of developing breast cancer. However, carcinogenesis is a complex, multistage process, usually involving more than one genetic change. Other epigenetic factors responsible for carcinogenesis involve epigenetic factors, such as level of hormones in the body, exposure to carcinogens and tumor promoting agents. These epigenetic factors do not produce cancer by themselves but enhances the likelihood of genetic mutation(s) resulting in cancer (Katzang et al. 2009). These genetic changes are categorized as - A. The activation of proto-oncogenes to oncogenes: Proto-oncogenes are the normal genes present in the cells and are responsible for controlling cell division, cell differentiation and apoptosis. A triggering factor such as a virus or exposure to any carcinogen brings malignant changes in the cell. B. The inactivation of tumor suppressor genes: A cell has the mechanism to protect itself from uncontrolled proliferation and tumor formation due to expression of genes called tumor suppressor genes. These genes possess the ability to suppress malignant changes and are also referred as antioncogenes. Mutation in proto-oncogenes or tumor suppressor genes results in the proliferation of tumor. Thus, a loss of function of tumor suppressor genes can be the critical event in carcinogenesis (Rang et al. 2007; Katzang 2009). More than 30 tumor suppressor genes as well as more than 100 dominant oncogenes have been found to be associated with various types of cancers (Rang et al. 2007). Characteristics of Cancer cells The genetic basis of cancer has been revealed through numerous animal models. The Cancer Genome Atlas aims at methodically differentiating the configurational source of cancer, through recognition of the genomic mutations linked with every cancer form. A corresponding progress and description forms the basis of understanding growth and external appearance of the cancer or tumor called the phenotype of the cancer, is essential for designing drugs that can ...Download file to see next pagesRead More
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Excellent paper! Used it to complete an assignment for a biology course. It was easy as ABC, for the first time in my life.
Discuss the causes and effects of cancer. To what extent is cancer prevention the individual's responsibility Provide researc
Cancer causes harm to the body when cells that are damaged divide without regulation to form tumors Some common types of cancer include breast cancer, brain cancer, leukemia (blood cancer), bone cancer, skin cancer, lung cancer, liver cancer, stomach cancer, and thyroid, just to mention a few.
6 Pages(1500 words)Essay
The repair pathway has been linked to colon cancer in humans via association between MI in colon tumours found in HNPCC families. MIs are short and repetitive sequences that are incorrectly copied by the DNA polymerase since the template and daughter strands found in the region are prone to misalignment.
3 Pages(750 words)Essay
Discuss the causes ans effects of cancer.to what extent is cancer prevention the individuals responsibility provide researched
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In 2012, the American cancer society estimated that over 226, 160 cases of cancer are anticipated by the end of the year and that 160, 340 deaths are expected to occur within the course of this year (5). The fatality of this disease has triggered a wide range of research to reveal the causes and predisposing factors of this disease as a core part of the fight against cancer in the world today.
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Estrogen is the hormone which supports the breast cancer to grow rapidly, but what actually causes breast cancer, is still a debate. However, hormones do play a big role in the growth of breast cancer. Studies have shown that breast cancer rate is high in those people
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If we have to differentiate between the normal cells and cancer cells, it can be noted that the cancer cell seems to have lost a number of vital control systems. Here comes the concept of genes which is the most important ingredient in the cell responsible for multiplication.
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Cancer has been a part of the human condition since recorded history. The earliest evidence of cancer is found among fossilized bone tumors, human mummies and manuscripts in ancient Egypt, dating to about 3000 B.C. The cause of cancer was variously attributed to the Gods,
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The age category of young women who can be prone to the cancer is placed at 40 years of age and below (MedineNet, 2014). The risks of getting breast cancer increases with aging, however, even younger women are at increased risk. This can be attributed to some risk
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Causes Of Cancer
Cancer is the second most common cause of death, killing 318 in every 100,000 Americans. It is predicted that over 1,500,000 new patients will be diagnosed with cancer and nearly 600,000 will die because of it in 2015 (American Cancer Society). Cancer occurs when cells undergo uncontrollable growth.
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