Nobody downloaded yet

Identification and analysis of DNA repair mechanisms - Thesis Example

Comments (0) Cite this document
Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues Abstract The human is exposed to a large number of agents each day that cause damage to the DNA within cell. Repair mechanisms play a crucial role in correcting the damage that has occurred, and allowing the cell to continue to replicate…
Download full paperFile format: .doc, available for editing
GRAB THE BEST PAPER98.6% of users find it useful
Identification and analysis of DNA repair mechanisms
Read TextPreview

Extract of sample
"Identification and analysis of DNA repair mechanisms"

Download file to see previous pages In both of these cases, DNA repair systems involve the use of the Mre11/Rad50/NBS1 complex. This project aims to identify and examine what DNA repair systems are present in the cells of Schizosaccharomyces pombe and how these contribute to resistance to treatment with nucleoside analogues. This information should help to provide further insight into the way in which human cells are able to develop resistance to this form of treatment, and perhaps provide some indication of a method to prevent this. Table of Contents Abstract 2 Introduction 4 DNA repair and cancer 6 DNA replication 7 DNA repair 9 MRN Complex 11 Topoisomerase inhibitors 13 Nucleoside analogues 15 Involvement of DNA repair 17 Project System 20 Aims and Objectives 21 References 22 Introduction In everyday life, cells are exposed to external and internal agents that cause thousands of DNA mutations per day. These mutations range from being small, such as affecting a single nucleotide, to large mutations where accurate repair can be difficult. For the accurate propagation of the genetic information within cells, it is essential that the body has mechanisms of repairing damage in a reliable manner. However, while many methods for DNA repair exist, these are not always successful and mutations can accumulate, resulting in the development of cancer (Helleday et al., 2007). Understanding these processes, why they occur the way that they do and what can be done to influence these is crucial for knowing the way that cancer occurs, and determining methods of treating it effectively. In our modern society, cancer has remained one of the most well studied diseases and perhaps one of the least understood. The fundamental aspects of cancer are damage in the DNA of a cell that results in a lack of control over cell growth and replication, as well reducing the likelihood that cells will enter apoptosis. These cells are able to proliferate well beyond the normal constraints of the tissue that they are in (Loeb and Loeb, 2000). With high levels of replication and low cell death, abnormal cells build up within the body and interfere with body functions. The exact mechanisms that causes these mutations to occur, and allows the cells to break free of the cell control pathway are the focus of much current research into cancer, as understanding these pathways may help to develop treatment or prevent cells from entering this state. Cancer is a disease where mutations in DNA accumulate to the point that traditional controls over cell behaviour can be bypassed, often involving the accumulation of mutations in genes responsible for the birth or death of the cell, as well as controls over the cell cycle (Lengauer et al., 1998). Research indicates that the tumours developed as the result of cancer are heterogeneous (Loeb et al., 2003). Because of this, cancer needs to be thought of as a collection of disease rather than a single disease (Huang et al., 2006). This is an important factor when studying cancer, as it explains why some mechanisms are prevalent in some forms of cancer, but not others. Genetic instability is thought to be one of the driving factors of the development of tumours and this in turn is driven by DNA damage and errors in the replication machinery. However, spontaneous mutation is only one aspect of the puzzle, and the prevalence of cancer development and succession of mutations ...Download file to see next pagesRead More
Cite this document
  • APA
  • MLA
(“Identification and analysis of DNA repair mechanisms Thesis”, n.d.)
Retrieved from https://studentshare.org/biology/1399928-identification-and-analysis-of-dna-repair
(Identification and Analysis of DNA Repair Mechanisms Thesis)
“Identification and Analysis of DNA Repair Mechanisms Thesis”, n.d. https://studentshare.org/biology/1399928-identification-and-analysis-of-dna-repair.
  • Cited: 0 times
Comments (0)
Click to create a comment or rate a document
Bacterial transmission
1.0. INTRODUCTION Bacterial transmission has been aided by contact with living organisms as well as by non-living. This is with respect to the ability of infectious organisms to flourish on inert surfaces (Ellis, 2006). According to Shrutz (2003) the microbes also thrive in the air below the 500 feet altitude including spores of Bacillus and Clostridium, algae, Micrococcus, Corynebacterium among others.
11 Pages(2750 words)Thesis
How is the AIS (automatic identification system) effective in Kuwait coast guard operation
The introduction and use of the Automatic Identification Systems (AIS) in ships that are required to follow the standards of SOLAS, also known as the Safety of Life at Sea convention by the International Maritime Organisation (IMO), has become fully accomplished (IMO 2001).
32 Pages(8000 words)Thesis
The mechanisms that underlay the repairs of DNA damages
pombe. This will be implemented by testing the sensitivity of the key mutants in DNA repair when acted upon by both Gemcitabine (dFdC) and Cytarabine (AraC). These two drugs are used in the treatment of various forms of cancer and are both nucleosides. Gemcitabine is commonly used in the treatment of various forms of solid tumors such as the pancreatic, bladder, breast and lung cancers.
22 Pages(5500 words)Thesis
SWOT analysis: strategic position and analysis of Dresser Rand
The purpose of the SWOT analysis is to evaluate the strategic position and analysis of Dresser-Rand. In which, its strengths, weaknesses, opportunities and threats have been taken into account. The strengths include the use of technology, innovation and efficiency enhancement and safety.
16 Pages(4000 words)Thesis
Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues
It is now recognised that DNA is constantly being damaged and repaired, and thus it is much more active than was previously considered. Damage to DNA occurs frequently from sources that are inside and outside the cell. This includes mutagenic environmental agents, such as chemicals which can be obtained both from the by-products of human industry and naturally from food product, as well as many other sources of mutation.
14 Pages(3500 words)Literature review
United States Uniform Personnel Identification System
With the terrorists activities increasing worldwide specifically after the disastrous attack of 9/11, it is made apparent to ensure the full security of the citizens of the most powerful country
35 Pages(8750 words)Thesis
Globalization: Analysis of Competitive Advantage
b. A need exists for a global strategy framework for firms to succeed in international competition and this global strategy framework need not emphasize producing as cheaply as possible to sell at the highest price. c. Although globalization offers
2 Pages(500 words)Thesis
DNA repair mechanisms role in survival to nucleoside analogues treatment in S.pombe
Repair mechanisms play a crucial role in correcting the damage that has occurred, and allowing the cell to continue to replicate. In cancer cells, which have high levels of replication and lack of apoptosis, DNA repair mechanisms can make
9 Pages(2250 words)Thesis
Marketing analysis for Construction Forensic
The image of the construction industry has been modified from consumer goods market to service market. The shift of the emphasis would provide numerous opportunities for Architectural and engineering firms and allow them to offer new services. In the light of improved opportunities, we find that the general contractors now offer a number of services such as: financial assistance, management of the total program, operations and maintenance, and renovation besides the core service of designing, building, and construction management1.
15 Pages(3750 words)Thesis
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Let us find you another Thesis on topic Identification and analysis of DNA repair mechanisms for FREE!
logo footer
Contact us:
Contact Us Now
FREE Mobile Apps:
  • StudentShare App Store
  • StudentShare Google play
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • Miscellaneous
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us