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Effect of Bcl-2 on Lung Cancer - Essay Example

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The context of this study is the effect of Bcl-2 single nucleotide polymorphisms on lung cancer. Bcl-2 has been proven to confer resistance to treatment for cancer cells through the activation of anti-apoptotic defenses in the cell (Xu et al., 2013)…
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Effect of Bcl-2 on Lung Cancer
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"Effect of Bcl-2 on Lung Cancer"

Download file to see previous pages To be able to obtain an accurate and strongly reliable research finding and study conclusion, the research method should always be aligned with the research hypothesis at all times. Back then, it was hypothesized in the study of Xu et al. (2013) that there can be a strong connection between Bcl-2 with a person’s susceptibility to lung cancer and its prognosis among the Chinese men. Specifically, the research hypothesis of Xu et al. (2013) is very much in-line with its chosen research method. It means that the authors’ decision to make use of its research method is good enough to determine whether or not the research hypothesis presented in the said study should be accepted or not.
For example, in the process of selecting and genotyping a total of 3 Bcl-2’s tagSNP (i.e. rs1564483, rs 1801018, and rs 2279115) in 1017 couple of Chinese male with lung cancer using the TaqMan assay, the authors were able to find out that the genotypes of rs1564483GA, AA, as well as GA+AA, were strongly related to the decrease in Chinese men’s susceptibility to lung cancer whereas the allele of rs1564483A increases Chinese men’s susceptibility of developing lung cancer particularly those who had family history of cancer and previous smoking habit. In this study, the clinical term “prognosis” is all about being able to foretell the possible long-term effects after a person has been diagnosed with lung cancer. Using the same research method, Xu et al. (2013) found out that research participants with Bcl-2 rs1564483 GA+AA genotypes are the ones who can experience longer survival rate and reduced risks of untimely deaths as compared to those Chinese men with rs1564483GG genotype.
The primary exposure of interest in this study was genetic factors, in particular, the polymorphism of the Bcl-2 gene in the Chinese men. This was measured by genotyping using the TaqMan method that used a sequence detection system (Xu et al, 2013). ...Download file to see next pagesRead More
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